Cytoskeletal crosstalk: A focus on intermediate filaments

Pradeau-Phélut, Lucas; Etienne-Manneville, Sandrine

doi:10.1016/j.ceb.2024.102325

Current Opinion in Cell Biology

2024

DOI: 10.1016/j.ceb.2024.102325

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Cytoskeletal crosstalk: A focus on intermediate filaments

Lucas Pradeau-Phélut,

Sandrine Etienne-Manneville

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Cited by 3 publications

References 72 publications

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Kinesin motor KIF16A regulates microtubule stability and actin‐dependent spindle migration in mouse oocyte meiosis

Wang,

Shi,

Zhang

et al. 2024

The FASEB Journal

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Kif16A, a member of the kinesin‐3 family of motor proteins, has been shown to play crucial roles in inducing mitotic arrest, apoptosis, and mitotic cell death. However, its roles during oocyte meiotic maturation have not been fully defined. In this study, we report that Kif16A exhibits unique accumulation on the spindle apparatus and colocalizes with microtubule fibers during mouse oocyte meiotic maturation. Targeted depletion of Kif16A using gene‐targeting siRNA disrupts the progression of the meiotic cell cycle. Furthermore, Kif16A depletion leads to aberrant spindle assembly and chromosome misalignment in oocytes. Our findings also indicate that Kif16A depletion reduces tubulin acetylation levels and compromises microtubule resistance to depolymerizing drugs, suggesting its crucial role in microtubule stability maintenance. Notably, we find that the depletion of Kif16A results in a notably elevated incidence of defective kinetochore‐microtubule attachments and the absence of BubR1 localization at kinetochores, suggesting a critical role for Kif16A in the activation of the spindle assembly checkpoint (SAC) activity. Additionally, we observe that Kif16A is indispensable for proper actin filament distribution, thereby impacting spindle migration. In summary, our findings demonstrate that Kif16A plays a pivotal role in regulating microtubule and actin dynamics crucial for ensuring both spindle assembly and migration during mouse oocyte meiotic maturation.

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Kinesin motor KIF16A regulates microtubule stability and actin‐dependent spindle migration in mouse oocyte meiosis

Wang,

Shi,

Zhang

et al. 2024

The FASEB Journal

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Mechanical Remodeling of Nuclear Biomolecular Condensates

Soggia,

ElMaghloob,

Boromangnaeva

et al. 2025

Physiology

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Organism health relies on cell proliferation, migration, and differentiation. These universal processes depend on cytoplasmic reorganization driven notably by the cytoskeleton and its force-generating motors. Their activity generates forces that mechanically agitate the cell nucleus and its interior. New evidence from reproductive cell biology revealed that these cytoskeletal forces can be tuned to remodel nuclear membrane-less compartments, known as biomolecular condensates, and regulate their RNA processing function for the success of subsequent cell division that is critical for fertility. Both cytoskeletal and nuclear condensate reorganization are common to numerous physiological and pathological contexts, raising the possibility that mechanical remodeling of nuclear condensates may be a much broader mechanism regulating their function. Here, we review this newfound mechanism of condensate remodeling and venture into contexts of health and disease where it may be relevant, with a focus on reproduction, cancer, and premature aging.

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Intermediate filaments at a glance

Coelho-Rato,

Parvanian,

Andrs Salajkova

et al. 2024

Journal of Cell Science

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Intermediate filaments (IFs) comprise a large family of versatile cytoskeletal proteins, divided into six subtypes with tissue-specific expression patterns. IFs have a wide repertoire of cellular functions, including providing structural support to cells, as well as active roles in mechanical support and signaling pathways. Consequently, defects in IFs are associated with more than 100 diseases. In this Cell Science at a Glance article, we discuss the established classes of IFs and their general features, their functions beyond structural support, and recent advances in the field. We also highlight their involvement in disease and potential use as clinical markers of pathological conditions. Finally, we provide our view on current knowledge gaps and the future directions of the IF field.

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Cytoskeletal crosstalk: A focus on intermediate filaments

Cited by 3 publications

References 72 publications

Kinesin motor KIF16A regulates microtubule stability and actin‐dependent spindle migration in mouse oocyte meiosis

Kinesin motor KIF16A regulates microtubule stability and actin‐dependent spindle migration in mouse oocyte meiosis

Mechanical Remodeling of Nuclear Biomolecular Condensates

Intermediate filaments at a glance

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