Cytotoxic Activities of Thiosemicarbazones and Their Metal Complexes

Jyothi, N. Rama; Farook, N.A. Mohammad; Cho, Migyung; Shim, Jaesool

doi:10.14233/ajchem.2013.oh106

Cited by 5 publications

(2 citation statements)

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“…One of the health problems in Indonesia is fungal infections, such as candidiasis and dermatomycosis [1][2][3][4]. During the past years, fungal infections have been increased due to the risen immunocompromised population (e.g., patients with AIDS or cancer, and organ transplant recipients).…”

Section: Introductionmentioning

confidence: 99%

Antifungal activities of Medinilla speciosa Blume fruit extracts against Candida albicans and Trichophyton rubrum

Milanda¹,

Fitri²,

Barliana³

et al. 2021

J Adv Pharm Educ Res

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Section: Introductionmentioning

confidence: 99%

Antifungal activities of Medinilla speciosa Blume fruit extracts against Candida albicans and Trichophyton rubrum

Milanda¹,

Fitri²,

Barliana³

et al. 2021

J Adv Pharm Educ Res

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“…They can act as N, S-multidentate ligands, and moreover, it is possible to modulate the binding properties/stoichiometries through the insertion of other heteroatoms into the backbone structure (i.e., phenolic or pyridyl moieties). They have a great variety of biological properties, both as free ligands and as metal complexes, and several studies have been published reporting on thiosemicarbazone-based complexes with medicinal applications [12][13][14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Biological Applications of Thiocarbohydrazones and Their Metal Complexes: A Perspective Review

2019

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Although organic compounds account for more than 99% of currently approved clinical drugs, the established clinical use of cisplatin in cancer or auranofin in rheumatoid arthritis have paved the way to several research initiatives to identify metal-based drugs for a wide range of human diseases. Nitrogen and sulfur donor ligands, characterized by different binding motifs, have been the subject in recent years of one of the main research areas in coordination chemistry. Among the nitrogen/sulfur compounds, very little is known about thiocarbohydrazones (TCH), the higher homologues of the well-known thiosemicarbazones (TSC), and their metal complexes. The extra hydrazine moiety provides the ligands of variable metal binding modes, structural diversity and promising biological implications. The interesting coordination chemistry of TCH has mainly been focused on symmetric derivatives, which are relatively simple to synthesize while few examples of asymmetric ligands have been reported. This informative review on TCHs and their metal complexes will be helpful for improving the design of metal-based pharmaceuticals for applications ranging from anticancer to antinfective therapy.

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Preparation of Novel Nickel Oxide@ Glutamic/Thiosemicarbazide Nanoparticles: Implications for Cytotoxic and Anti-cancer Studies in MCF-7 Breast Cancer Cells

et al. 2021

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Cytotoxic Activities of Thiosemicarbazones and Their Metal Complexes

Cited by 5 publications

References 0 publications

Antifungal activities of Medinilla speciosa Blume fruit extracts against Candida albicans and Trichophyton rubrum

Antifungal activities of Medinilla speciosa Blume fruit extracts against Candida albicans and Trichophyton rubrum

Biological Applications of Thiocarbohydrazones and Their Metal Complexes: A Perspective Review

Preparation of Novel Nickel Oxide@ Glutamic/Thiosemicarbazide Nanoparticles: Implications for Cytotoxic and Anti-cancer Studies in MCF-7 Breast Cancer Cells

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