Cytotoxic and anti-HIV-1 activities of triterpenoids and flavonoids isolated from leaves and twigs of Gardenia sessiliflora

Thanasansurapong, Sariyarach; Tuchinda, Patoomratana; Reutrakul, Vichai; Pohmakotr, Manat; Piyachaturawat, Pawinee; Chairoungdua, Arthit; Suksen, Kanoknetr; Akkarawongsapat, Radeekorn; Limthongkul, Jitra; Napaswad, Chanita; Nuntasaen, Narong

doi:10.1016/j.phytol.2019.10.007

Cited by 12 publications

(5 citation statements)

References 27 publications

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“…and Twigs of Gardenia Sessiliflora (Thanasansurapong et al, 2019) Uji sitotoksik dan uji aktivitas anti-HIV dari isolat flavonoid pada daun dan batang Gardenia sessiliflora.…”

Section: Cytotoxic and Anti-hiv-1 Activities Of Triterpenoids And Fla...unclassified

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Potensi Flavonoid Bahan Alam Sebagai Anti-HIV Guna Mengatasi Darurat Infeksi HIV di Indonesia

Azriz,

Ibrahim,

Maulana

et al. 2024

SCRIPTA SCORE Sci Med J.

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Background: Human Immunodeficiency Virus (HIV) infection is an unresolved health problem in various countries. Indonesia is rich in various potential natural resources and is able to support the development of HIV therapy through the use of bioactive components from plants, one of which is flavonoid compounds which need to be investigated for their potential anti-HIV activity. Objective: To determine the anti-HIV potential of natural compound flavonoids. Method: The method used is a narrative literature review, with literature collection obtained from PubMed, ScienceDirect and Google Scholar. The selected articles are those published in the last ten years (2013-2022) and full text is available. Result and Discussion: 24 articles included related to flavonoid and HIV. Indonesia is in an emergency situation for HIV infection, antiretroviral drugs (ARV) can only inhibit the development of the virus, but do not kill the virus directly. The antiviral potential of flavonoid compounds makes this substance an opportunity to be studied in HIV infection. The flavonoid subclasses myricetin, herbacitrin, and chalcone have the best anti-HIV activity. The natural ingredient that has the highest flavonoid such as sea fern spores, dragon fruit with a content of 0.14 - 0.15 mg/g, Moringa leaves with a content of 7.79 mg/g, and cinnamon with a fairly high content. Conclusion: Flavonoids have anti-HIV potential with different mechanisms according to the type of flavonoid compounds contained. Flavonoids are mostly contained in sea fern spores, and are also found in dragon fruit, cinnamon and Moringa leaves, which are natural ingredients that are easily available every day. Latar Belakang: Infeksi Human Immunodeficiency Virus (HIV) merupakan masalah kesehatan yang belum terselesaikan pada berbagai negara di dunia. Indonesia merupakan negara yang kaya akan berbagai sumber daya alam yang potensial dan mampu mendukung pengembangan terapi HIV melalui pemanfaatan komponen bioaktif dari tumbuhan, salah satunya adalah senyawa flavonoid yang perlu ditelitipotensi aktivitas anti-HIVnya. Tujuan: Mengetahui potensi anti-HIV dari senyawa flavonoid bahan alam Metode: Metode yang digunakan adalah tinjauan literatur naratif, dengan pengumpulan literatur dilakukan melalui database PubMed, ScienceDirect, dan Google Scholar. Artikel yang dipilih adalah yang terbit sepuluh tahun terakhir (2013-2022) dan tersedia full text. Pembahasan: 24 artikel didapatkan membahas flavonoid dan kaitannya pada HIV. Indonesia berada dalam kondisi darurat infeksi HIV, obat antiretroviral (ARV) hanya dapat menghambat perkembangan virus, namun tidak membunuh virus secara langsung. Adanya potensi antivirus dari senyawa flavonoid menjadikan zat ini berpeluang untuk diteliti pada penyakit infeksi HIV. Flavonoid subkelas myricetin, herbacitrin, dan kalkon memiliki aktivitas anti-HIV yang paling baik. Bahan alam yang mempunyai kandungan flavonoid tertinggi di antaranya spora paku laut, buah naga dengan kandungan sebesar 0,14 – 0,15 mg/g, daun kelor dengan kandungan sebesar 7,79 mg/g, dan kayu manis dengan kandungan cukup tinggi. Kesimpulan: Flavonoid memiliki potensi anti-HIV dengan mekanisme yang berbedabeda sesuai dengan jenis senyawa flavonoid yang terkandung. Flavonoid paling banyak terkandung dalam spora paku laut, serta juga ditemukan pada buah naga, kayu manis, dan daun kelor yang merupakan bahan alam yang mudah didapatkan sehari-hari.

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“…and Twigs of Gardenia Sessiliflora (Thanasansurapong et al, 2019) Uji sitotoksik dan uji aktivitas anti-HIV dari isolat flavonoid pada daun dan batang Gardenia sessiliflora.…”

Section: Cytotoxic and Anti-hiv-1 Activities Of Triterpenoids And Fla...unclassified

“…Semua senyawa flavonoid yang terkonfirmasi memiliki aktivitas anti-HIV pada uji syncytium reduction assay. [21] 7.…”

Section: Cytotoxic and Anti-hiv-1 Activities Of Triterpenoids And Fla...unclassified

Potensi Flavonoid Bahan Alam Sebagai Anti-HIV Guna Mengatasi Darurat Infeksi HIV di Indonesia

Azriz,

Ibrahim,

Maulana

et al. 2024

SCRIPTA SCORE Sci Med J.

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“…When an anti-HIV-1 RT assay was performed, cirsimaritin displayed moderate activity with 52.50% inhibition at 200 μg/mL [ 157 ].…”

Section: Biological Activitymentioning

confidence: 99%

Stevia Genus: Phytochemistry and Biological Activities Update

et al. 2021

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The Stevia genus (Asteraceae) comprises around 230 species, distributed from the southern United States to the South American Andean region. Stevia rebaudiana, a Paraguayan herb that produces an intensely sweet diterpene glycoside called stevioside, is the most relevant member of this genus. Apart from S. rebaudiana, many other species belonging to the Stevia genus are considered medicinal and have been popularly used to treat different ailments. The members from this genus produce sesquiterpene lactones, diterpenes, longipinanes, and flavonoids as the main types of phytochemicals. Many pharmacological activities have been described for Stevia extracts and isolated compounds, antioxidant, antiparasitic, antiviral, anti-inflammatory, and antiproliferative activities being the most frequently mentioned. This review aims to present an update of the Stevia genus covering ethnobotanical aspects and traditional uses, phytochemistry, and biological activities of the extracts and isolated compounds.

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“…Several Gardenia species have proved to have potent cytotoxic phytochemicals [2][3][4][5][6][7] . Previous studies on Gardenia species revealed the presence of diverse phytochemicals including monoterpenes 8 , triterpenes 9 , saponins 2 , flavonoids 10 , iridoids, and lignans 11 . This study revealed promising in vitro cytotoxic activities of the non-polar fractions of G. thunbergia L. f. aerial parts against HL-60 and HepG2 cell lines.…”

Section: Introductionmentioning

confidence: 99%

Exploration of Components Contributing to Potent Cytotoxicity of Gardenia Thunbergia L. F. Against Human Leukemia and Hepatoma

Mohamed

Ross

Mohamed

2022

Bulletin of Pharmaceutical Sciences. Assiut

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Promising cytotoxic effects of several Gardenia species (Rubiaceae) have been established by many studies. The current study evaluated MTT-based cytotoxic activities of the crude extract from Gardenia thunbergia L. f. aerial parts and four fractions thereof, including nhexane, dichloromethane (DCM), ethyl acetate, and aqueous, against human leukemia (HL-60) and hepatoma (HepG2) cell lines, as well as the normal (WI38) cell line. Both non-polar fractions, n-hexane and dichloromethane, showed tumor-selective toxicities against both tested cancerous cell lines. These results sparked our interest in chemically characterising these bioactive fractions to reveal their cytotoxic components. The composition of n-hexane-soluble fraction was investigated via GC-MS analysis, while column chromatographic separation was used to isolate the components of DCM-soluble fraction. These isolated phytochemicals were identified via spectroscopic analyses. Besides, the chemotaxonomic value of the detected phytochemicals and their reported cytotoxic profiles were discussed.

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Cytotoxic and anti-HIV-1 activities of triterpenoids and flavonoids isolated from leaves and twigs of Gardenia sessiliflora

Cited by 12 publications

References 27 publications

Potensi Flavonoid Bahan Alam Sebagai Anti-HIV Guna Mengatasi Darurat Infeksi HIV di Indonesia

Potensi Flavonoid Bahan Alam Sebagai Anti-HIV Guna Mengatasi Darurat Infeksi HIV di Indonesia

Stevia Genus: Phytochemistry and Biological Activities Update

Exploration of Components Contributing to Potent Cytotoxicity of Gardenia Thunbergia L. F. Against Human Leukemia and Hepatoma

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