Cytotoxic and apoptosis-inducing effect of ent-15-oxo-kaur-16-en-19-oic acid, a derivative of grandiflorolic acid from Espeletia schultzii

Ruiz, Y.; Rodrígues, Juan; Arvelo, Francisco; Usubillaga, Alfredo; Monsalve, M. Hernández; Dı́ez, Nardy; Galindo-Castro, Iván

doi:10.1016/j.phytochem.2007.07.025

Cited by 28 publications

(14 citation statements)

References 21 publications

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“…We elucidated the structure by using standard and multi-dimensional NMR spectroscopy. Finally, we compared our 1 H and 13 C NMR data with those of the known compound ent-15-oxokaur-16-en-19-oic acid (EOKA) (Figure 2B) and proved to be identical to the literature data [17-19]. …”

Section: Resultssupporting

confidence: 65%

Characterization of the antiproliferative activity of Xylopia aethiopica

et al. 2012

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BackgroundXylopia aethiopica, a plant found throughout West Africa, has both nutritional and medicinal uses. The present study aims to characterize the effects of extracts of this plant on cancer cells.ResultsWe report that X. aethiopica extract prepared with 70% ethanol has antiproliferative activity against a panel of cancer cell lines. The IC50 was estimated at 12 μg/ml against HCT116 colon cancer cells, 7.5 μg/ml and > 25 μg/ml against U937 and KG1a leukemia cells, respectively. Upon fractionation of the extract by HPLC, the active fraction induced DNA damage, cell cycle arrest in G1 phase and apoptotic cell death. By using NMR and mass spectrometry, we determined the structure of the active natural product in the HPLC fraction as ent-15-oxokaur-16-en-19-oic acid.ConclusionThe main cytotoxic and DNA-damaging compound in ethanolic extracts of Xylopia aethiopica is ent-15-oxokaur-16-en-19-oic acid.

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Section: Resultssupporting

confidence: 65%

Characterization of the antiproliferative activity of Xylopia aethiopica

et al. 2012

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“…This IC 50 value of the most cytotoxic compound A was used for further evaluations. The timedependent effects on cell growth were measured according to previous procedures [11,12].…”

Section: Methodsmentioning

confidence: 99%

Effect of quinolinyl acrylate derivatives on prostate cancer in vitro and in vivo

et al. 2011

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Quinolines and acrylates are chemical compounds which were previously described as potential antitumor agents. In this study, a series of seven new quinolinyl acrylate derivatives were synthesized and evaluated against human prostate cancer cells PC-3 and LNCaP in vitro and in vivo. The most effective compound (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4 hydroxyphenyl) acrylate reduced the viability in both cell lines in a time- and dose-dependent manner. Inhibitory effects were also observed on the adhesion, migration, and invasion of the prostate cancer cells as well as on the neoangiogenesis, clonogenic and MMP-9 activity. The effect in vivo was studied in PC-3 xenografts in nude mice. The results were concordant with the in vitro effects and showed decreased tumor growth in treated animals compared to controls. The study suggests the multi-target efficacy of the quinolinyl derivate against human prostate cancer cells and supports its potential therapeutic usefulness.

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“…Further evaluations of the best compounds were performed using the IC 50 values. The time-dependent effects of the chalcones on cell growth were measured as previously described (14). Briefly, PC-3 cells (1×10 5 ) and LNCaP cells (2.4×10 5 ) were seeded in six-well plates in RPMI containing 10% fetal bovine serum and the compounds at their IC 50 .…”

Section: Cell Viability and Cell Growth Evaluationmentioning

confidence: 99%