Cytotoxic antibodies in sera of Venezuelan multiparous women of Amerindian and mixed ethnic origin

Abstract

Sera from 464 multiparous women of mixed ethnic origin and 114 Amerindian mothers (Warao of Western Venezuela), were studied for lymphocytotoxicity using a panel of B and T lymphocytes isolated from 50 to 100 individuals from the same populations. Twenty-five and 9.65% of thc sera, respectively, showed activity against at least 5% of the panel. Among the women of mixed ethnic origin 10% produced antibodies directed against one or more HLA Class 1 antigens while 2 sera contained monospecific anti-DR antibodies; among the Warao, only 2 sera recognized HLA antigens: a Bw51 and an undetermined Cw antigen which shows linkage disequilibrium with Bw16 in both populalions.

Role of anti-human lymphocyte culture cytotoxic antibodies in recurrent spontaneous pregnancy loss women

“…These are due to variations in immunization and the resultant outcomes. Values range from 7.3% to 36% (7.3%, Swedish women;[9] 18.7%, Caucasian women;[10] 21.6%, American women;[11] 29%, Mestizo women[11] and 9.6%, Warao women;[11] Venezulean women;[12] 36% USA women[13] and south Indian women 10.6%. [14] Another study detected anti-HLA antibodies in only 5% of women with successful pregnancies during the first trimester, compared with an antibody prevalence of 10% in women who miscarried.…”