2016
DOI: 10.1080/14786419.2016.1230115
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Cytotoxic halogenated monoterpenes from Plocamium cartilagineum

Abstract: As a result of our efforts to identify bioactive agents from marine algae, we have isolated and identified one new halogenated monoterpene 1 [(−)-(5E,7Z)-3,4,8-trichloro-7-dichloromethyl-3-methyl-1,5,7-octatriene] in addition to three known compounds (2, 3 and 4) from the red alga Plocamium cartilagineum collected by hand from the eastern coast of South Africa. Compound 1 was found to be active as a cytotoxic agent in human lung cancer (NCI-H460) and mouse neuro-2a cell lines (IC50 4 μg/ml). Two of these compo… Show more

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Cited by 18 publications
(10 citation statements)
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“…The anti-cancer activity of nine halogenated monoterpenes isolated from the red alga P. cartilagineum has been highlighted on murine colon adenocarcinoma CT26 cells, human colon adenocarcinoma SW480 cells, human cervical adenocarcinoma HeLa cells and human malignant melanoma SkMel28 cells [ 13 ]. More recently, Sabry et al [ 36 ] reported the identification of four halogenated monoterpenes purified also from the red alga P. cartilagineum as a cytotoxic agents in human leukemia, lung, colon cancer cells and mouse neuro-2a cell lines [ 36 ]. However, the underlying anti-tumor mechanisms of these reported halogenated monoterpenses are still uncovered.…”
Section: Discussionmentioning
confidence: 99%
“…The anti-cancer activity of nine halogenated monoterpenes isolated from the red alga P. cartilagineum has been highlighted on murine colon adenocarcinoma CT26 cells, human colon adenocarcinoma SW480 cells, human cervical adenocarcinoma HeLa cells and human malignant melanoma SkMel28 cells [ 13 ]. More recently, Sabry et al [ 36 ] reported the identification of four halogenated monoterpenes purified also from the red alga P. cartilagineum as a cytotoxic agents in human leukemia, lung, colon cancer cells and mouse neuro-2a cell lines [ 36 ]. However, the underlying anti-tumor mechanisms of these reported halogenated monoterpenses are still uncovered.…”
Section: Discussionmentioning
confidence: 99%
“…A new linear pentachloromonoterpene 886 was isolated from Plocamium cartilagineum. 374 Although the paper claimed the compound to be a diastereomer of a compound also previously isolated from P. cartilagineum, it would appear this it is actually the (À)-enantiomer of this compound. 375 An unusual cyclic ether 887 has been reported from Kappaphycus alvarezii, however the NMR and MS spectra reported for this compound do not support the proposed structure.…”
Section: Red Algaementioning
confidence: 97%
“…Last year, was reported the isolation of halogenated monoterpenes 25 , 31 and 32 from the red alga Plocamium cartilagineum (Linnaeus) P.S.Dixon (syn. Plocamium cartilagineum ) collected in South Africa [ 48 ]. Additionally, the compounds’ cytotoxic effects were evaluated and stereoisomers 25 and 31 exhibit identical and significant cytotoxicity against colon cancer cell line (IC 50 = 3.3 µM) and low effect against lung cancer cell line (NCI-H460) [ 48 ].…”
Section: Secondary Metabolites From Seaweeds With In Vitro Cytotoxmentioning
confidence: 99%
“…Plocamium cartilagineum ) collected in South Africa [ 48 ]. Additionally, the compounds’ cytotoxic effects were evaluated and stereoisomers 25 and 31 exhibit identical and significant cytotoxicity against colon cancer cell line (IC 50 = 3.3 µM) and low effect against lung cancer cell line (NCI-H460) [ 48 ]. In the attempt to find the possible mechanism of action was confirmed that none of the compounds have activity as sodium channel blockers or activators [ 48 ].…”
Section: Secondary Metabolites From Seaweeds With In Vitro Cytotoxmentioning
confidence: 99%