Cytotoxic Natural Products from Marine Sponge-Derived Microorganisms

Zhang, Huawei; Zhao, Zhongxiang; Wang, Hong

doi:10.3390/md15030068

Cited by 66 publications

(48 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is important to understand the distinction between species, as there is a growing interest in natural products and other biobased studies from tetillids (e.g. Cleary et al 2013, Mokhlesi et al 2017, Zhang et al 2017). We expect that the current study can provide a solid basis for subsequent species descriptions of Indo-Pacific species of the genera Cinachyrella and Paratetilla .…”

Section: Resultsmentioning

confidence: 99%

Unravelling the moons: review of the genera Paratetilla and Cinachyrella in the Indo-Pacific (Demospongiae, Tetractinellida, Tetillidae)

Santodomingo¹,

Becking²

2018

View full text Add to dashboard Cite

Paratetillabacca (Selenka, 1867) and Cinachyrellaaustraliensis (Carter, 1886) occur in a broad range of marine environments and are allegedly widely distributed species in the Indo-Pacific. We coin the term ‘moon sponges’ for these species as they are spherical in shape with numerous porocalices resembling the lunar surface. Both species have a complex taxonomic history with high synonymization, in particular by Burton (1934, 1959). An examination of the junior synonyms proposed by Burton (1934, 1959) was conducted to establish the validity of the names. More than 230 specimens from Naturalis Biodiversity Center were reviewed that belong to the genera Paratetilla and Cinachyrella from marine lakes, coral reefs, and mangroves in Indonesia. The aim of the current study was to untangle the taxonomic history, describe the collection of moon sponges from Indonesia, and develop a key. We extensively reviewed the taxonomic literature as well as holotypes of most of the species synonymized by Burton. The taxonomic history of Paratetilla spp. and Cinachyrellaaustraliensis showed some cases of misinterpreted synonyms, misidentifications, and lack of detailed descriptions for some species. The conclusion of the revision is that there are three valid species of Paratetilla (P.arcifera, P.bacca, and P.corrugata) and four valid species of Cinachyrella (C.australiensis, C.porosa, C.paterifera, and C.schulzei) in Indonesia. This is furthermore corroborated by molecular work from previous studies. ParatetillaarciferaWilson 1925 and C.porosa (Lendenfeld, 1888) are resurrected. A full review of taxonomic history is provided as well as a key for identification of moon sponges from Indonesia. All species are sympatric and we expect that there are undescribed species remaining within the Tetillidae from the Indo-Pacific. Our current review provides the framework from which to describe new species in the genera Paratetilla and Cinachyrella from the Indo-Pacific.

show abstract

Section: Resultsmentioning

confidence: 99%

Unravelling the moons: review of the genera Paratetilla and Cinachyrella in the Indo-Pacific (Demospongiae, Tetractinellida, Tetillidae)

Santodomingo¹,

Becking²

2018

View full text Add to dashboard Cite

show abstract

“…This review highlights but a few of the compounds produced by microbial symbionts that have potential as pharmaceuticals [8,73,95,96]. For example, we draw readers to the recent excellent review by Zhang et al which describes in detail over 107 cytotoxic agents which have been discovered from 1955 to 2016 that are metabolized by marine sponge-derived symbionts alone [95] (including terpenes, alkaloids, peptides, aromatics, lactones, and steroids, amongst others).…”

Section: Constraints and Future Prospectsmentioning

confidence: 99%

“…For example, we draw readers to the recent excellent review by Zhang et al which describes in detail over 107 cytotoxic agents which have been discovered from 1955 to 2016 that are metabolized by marine sponge-derived symbionts alone [95] (including terpenes, alkaloids, peptides, aromatics, lactones, and steroids, amongst others). Several other recent detailed reviews are also available which provide information on the many compounds discovered from marine invertebrates, including cytotoxic, anti-microbial, anti-protozoal, anti-leishmanial, anti-trypanosomal and anti-inflammatory compounds, compounds which may actually originate from the host-associated microbes and not the invertebrates themselves [8,19,20,48,[97][98][99][100][101][102][103][104][105][106].…”

Section: Constraints and Future Prospectsmentioning

confidence: 99%

Symbiotic Microbes from Marine Invertebrates: Driving a New Era of Natural Product Drug Discovery

et al. 2017

View full text Add to dashboard Cite

Abstract:Invertebrates account for more than 89% of all extant organisms in the marine environment, represented by over 174,600 species (recorded to date). Such diversity is mirrored in (or more likely increased by) the microbial symbionts associated with this group and in the marine natural products (or MNPs) that they produce. Since the early 1950s over 20,000 MNPs have been discovered, including compounds produced by symbiotic bacteria, and the chemical diversity of compounds produced from marine sources has led to them being referred to as "blue gold" in the search for new drugs. For example, 80% of novel antibiotics stemming from the marine environment have come from Actinomycetes, many of which can be found associated with marine sponges, and compounds with anti-tumorigenic and anti-diabetic potential have also been isolated from marine symbionts. In fact, it has been estimated that marine sources formed the basis of over 50% of FDA-approved drugs between 1981 and2002. In this review, we explore the diversity of marine microbial symbionts by examining their use as the producers of novel pharmaceutical actives, together with a discussion of the opportunities and constraints offered by "blue gold" drug discovery.

show abstract

“…Previous chemical investigation indicated that Aspergillus genus is one of rich producers of terpenes, alkaloids, peptides, aromatics with a broad spectrum of biological activities (Zhang et al, 2017). Therefore, natural products …”

Section: Discussionmentioning

confidence: 99%

“…These microbes have potential capability to produce bioactive secondary metabolites with a broad spectrum of application in the field of medicine and agriculture (Bhatnagar et al, 2010;Zhang et al, 2017). More interestingly, marine sponge-derived fungi accounted for the largest number (33%) of natural products and had the highest number of new compounds during the period from 2003 to 2012 (Pejin et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial evaluation of the crude extract of symbiotic fungi from marine sponge Reniera japonica

Dong

Lai

et al. 2018

Bangladesh J Pharmacol

Self Cite

View full text Add to dashboard Cite

Marine sponge-derived microbes are one of the rich sources of bioactive natural products with a broad spectrum of bioactivities. The present work focuses on the isolation and antimicrobial screening of the marine sponge-associated fungi from Reniera japonica MNP-2016. The results indicated that five fungi (L1-2, L2-1, L4, L8-1 and L14) were successfully isolated. Bioassay tests showed that only strain L14 had strong inhibitory effect on the pathogens, Staphyloccocus aureus, Escherichia coli and Candida albicans. 18S rDNA sequence analysis indicated that strain L14 was ascribed to Aspergillus genus. To the best of our knowledge, this work was the first report on the isolation and antimicrobial evaluation of fungi from R. japonica.Video Clip of Methodology:1 min 13 sec: <a href="https://www.youtube.com/v/RSA2icw3emg">Full Screen</a> <a href="https://www.youtube.com/watch?v=RSA2icw3emg">Alternate</a>

show abstract

Cytotoxic Natural Products from Marine Sponge-Derived Microorganisms

Cited by 66 publications

References 57 publications

Unravelling the moons: review of the genera Paratetilla and Cinachyrella in the Indo-Pacific (Demospongiae, Tetractinellida, Tetillidae)

Unravelling the moons: review of the genera Paratetilla and Cinachyrella in the Indo-Pacific (Demospongiae, Tetractinellida, Tetillidae)

Symbiotic Microbes from Marine Invertebrates: Driving a New Era of Natural Product Drug Discovery

Antimicrobial evaluation of the crude extract of symbiotic fungi from marine sponge Reniera japonica

Contact Info

Product

Resources

About