Cytotoxic triterpenes from Salvia buchananii roots

Abstract

A pentacyclic triterpene, named salvibuchanic acid (1), together with five known compounds, were isolated from the roots of Salvia buchananii Hedge (Lamiaceae). The structural characterisation of all compounds was performed by spectroscopic analyses, including 1D and 2D NMR and HRESIMS experiments. The lupane triterpene (1) and hyptadienic acid (2) were investigated for their potential cytotoxic activity on Jurkat, HeLa and MCF7 cell lines. Both compounds showed an interesting antiproliferative activity with similar potency in all cell lines. By means of flow cytometric studies, hyptadienic acid (2) induced in HeLa cells a S cell cycle block, while 1 elicited both cytostatic and cytotoxic responses.

A Review on the Ethnopharmacology and Phytochemistry of the Neotropical Sages (Salvia Subgenus Calosphace; Lamiaceae) Emphasizing Mexican Species

“…From the chloroform extract of the aerial parts of S. ballotiflora antitumoral and cytotoxicity activities were described ( Campos-Xolalpa et al, 2017 ; Campos-Xolalpa et al, 2021 ), in part due to the presence of 7,20-dihydroanastomosine, 7α-acetoxy-6,7-dihydroicetexone, and anastomosine ( Esquivel et al, 2017 ), as well as 19-deoxyisoicetexone ( Campos-Xolalpa et al, 2017 ). From the roots of S. buchananii it was isolated hyptadienic and salvibuchanic acids ( Beladjila et al, 2018b ), and tilifolidione from S. semiatrata ( Esquivel et al, 2005 ). Whereas from the aerial parts of S. leucantha , salvileucantholide were evaluated using MTT assay ( Jiang et al, 2016 ) ( Table 1 ), a colorimetric assay to measure cellular metabolic activity as an indicator of cell viability, proliferation, and cytotoxicity.…”

A New Triterpene Glucoside from Genista numidica

“…A wide range of biological and pharmacological properties has been reported for this genus, such as antimicrobial [8], antioxidant [9], and antiproliferative activities [10]. In the course of our studies on Algerian medicinal plants [11,12], herein the isolation and structural characterization of a new oleanolic acid triterpene glucoside (1) along with twelve known compounds, are reported from the chloroform and ethyl acetate extracts of G. numidica Spach aerial parts, an endemic trifoliate Algerian species, growing on moist forest floors commonly called Teqtaq. To date only the chemical composition and antimicrobial activity of G. numidica essential oil were reported [13], but no phytochemical investigation has never been carried out.…”

Triterpenes from Salvia argentea var. aurasiaca and their antibacterial and cytotoxic activities

“…The genus Salvia (family Lamiaceae), comprising about 900 species, widely distributed in various regions of the world, is represented by about 23 species in the Algerian flora, of which five are endemic [1]. Several investigations showed that Salvia species contain triterpenoids, diterpenoids, monoterpenes, and polyphenolics [2][3][4][5][6][7][8][9][10][11][12]. Salvia species possess biological properties e.g.…”

“…In continuation of our research on the chemical constituents of S. argentea var. aurasiaca, we describe here the isolation and structural characterization of five new ursane-type triterpenes (1)(2)(3)(4)(5) along with five known compounds (6)(7)(8)(9)(10) from the acetone extract of its powdered dried aerial parts (Fig. 1).…”