Cytotoxicity Activity of Some Indian Medicinal Plants

Abstract

Objective: The current study is carried out to evaluate cytotoxicity activity of the methanolic extracts of some medicinal (Buchanania axillaris Desr, Tamilnadia ulignosa Retz, Phaseolus semierectus L and Stylosanthes fruticosa Retz).Methods: Cytotoxicity activity was evaluated on human cancer cell lines such as lung cancer (A549) and skin cancer (A431) using MTT assay method. Results:The selected plant extracts showed the dose-dependent cytotoxicity activity on the tested cell lines. The cytotoxicity variations on different cell lines were also observed for tested plants extracts. The cytotoxicity of the extracts was increased as the concentration of them was increased. Among all tested plants extracts Phaseolus semierectus showed the better cytotoxicity activity on tested cell lines. Conclusion:The results of the present study supported the folkloric usage of the studied plants and confirmed that the plant's extracts have the bioactive constituents with cytotoxic properties and their isolation can be useful for developing new anticancer drugs.

Assessment of Photoprotective, Antioxidant and Anti-Skin Cancer Activities of Leaf Extracts of Certain Medicinal Plants

“…The results indicated that P. discoridis had the highest antitumor activity against the human skin tumor cell line (A431). The obtained results are supported by previous studies where plant extracts rich in flavonoids had a strong inhibition of the growth of A431 cell lines (Mohansrinivasan et al, 2015;Neerugatti et al, 2016;Zeng et al, 2018). Also, the anti-skin cancer activity of P. discoridis was higher than that of the standard chemotherapeutic drug (doxorubicin).…”

Anticancer and Cytotoxicity Enhancement Activity in Combination With Synthetic Drug and Ethanolic Extracts From Ficus religiosa (Peepal Tree) Used in Cancer Cell Line Culture (Breast Cancer)

“…For primary (nondividing) cells, drug sensitivity is measured as enhanced cell kill of treated cells as compared to the loss of cells already commonly seen in untreated cells. This experiment is designed based on different research paper review [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]…”

Vanillin Extracted From Proso Millet and Barnyard Millet Induce Apoptosis in Ht-29 and McF-7 Cell Line Through Mitochondria Mediated Pathway

“…In recent years, natural product and imitative from the natural product as a new anticancer drug and antibiotics are permitted by US Food and Drug Administration (FDA) [8][9][10]. Natural products mostly from plant source have an important basis for discovering new bioactive components with few side effects and high efficacy [11]. Anticancer properties have been revealed against a broad range of cancers by numerous foods, for example, grains, cereals, spices, vegetables, and medicinal plants and their bioactive compounds [12].…”