Cytotoxicity and antihyperglycemic effect of minor constituents from Rhizoma Coptis in HepG2 cells

Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways

“…Coptisine, berberine, palmatine with a purity of 98.0%, 97.6%, 96.8%, respectively (by HPLC analysis, see supplementary material 1: Fig. 1), were separated from RC according to previous methods of our lab [13]. The spectrum data of these compounds were supplemented in the supplementary materials (supplementary material 1: Fig.…”

“…According to Ben Cao Bei Yao (Wang Ang in 1683 CE), RC can be used to clearing heat and purging fire, resolving phlegm to activate meridians, promoting blood circulation to remove blood stasis, removing dampness, nourishing kidney and intestine. The major pharmacological components in RC are alkaloids, including berberine, coptisine, palmatine, epiberberine and these compounds are used as criteria in the quality control of RC [13]. The main pharmacodynamic properties of RC have long been recognized in the treatment of intestinal infections and diabetes (recognized as Xiao Ke Zheng in ancient China), which can be linked to their antibacterial, glucoselowering and anti-inflammatory effects [14].…”

Safety evaluation of main alkaloids from Rhizoma Coptidis

“…RC mainly consisted of various alkaloids, including berberine, coptisine, palmatine and epiberberine (Chen et al, 2012) (Fig. 1), which are used as standard for its quality control in Chinese pharmacopoeia 2010 edition (Committee, 2010).…”

“…(Lv et al, 2003). Moreover, studies have demonstrated that RC possess a diverse array of pharmacological and biochemical properties, such as anti-Alzheimer and antioxidant (Jung et al, 2009), antihyperglycemic (Chen et al, 2012), hepatoprotective (Ye et al, 2009;Feng et al, 2011), analgesic (Tjong et al, 2011), anti-inflammatory (Lu et al, 2011), antibacterial (Choi et al, 2007, and antineoplastic …”

Inhibitory Effects of Various Ratios of Polysaccharides/Alkaloids from Rhizome of <i>Coptis chinensis</i> Franch on α-Glucosidase

“…It has been used for thousands of years in Chinese traditional medicine to treat damp-heat, dysentery, jaundice, heart fire hyperactivity, carbuncles and sores [2]. Increasingly modern pharmacological investigations have demonstrated that the extracts/compounds isolated from RCC can be used to treat inflammation [3], infection [4], dysentery [5], hypertension [6], gastrointestinal cancer [7], and type 2 diabetes mellitus (T2DM) [8]. In addition, recent research has also reported that RCC contains various chemical constituents including alkaloids, polysaccharides, and organic acids [8][9][10][11].…”