Cytotoxicity and Antimicrobial Activity of Chromium Picolinate Mediated Zinc Oxide Nanoparticle

Abstract

Aim: To study the chromium picolinate mediated with zinc oxide nanoparticle and its cytotoxicity and antimicrobial activity
 Introduction: Chromium can alleviate glucose intolerance and insulin resistance and it is involved in the metabolism of glucose, lipid, protein, and nucleic acid .Chromium picolinate [CrPic], also named as picolinic acid chromium and several studies have proved that CrPic, as the source of Chromium, can alleviate the high level of blood glucose, blood lipid, insulin, and cholesterol in the patients with metabolic syndrome and zinc oxide [ZnO] has also gained momentum due to their unique properties in the process of nanotechnology. Chromium picolinate works together with insulin that produced by the pancreas to metabolize carbohydrates. It's made by combining chromium with picolinic acid. The acid helps the body absorb chromium. Randomized controlled trials have failed to demonstrate a link between chromium supplementation and the prevention or treatment of type 2 diabetes or impaired glucose tolerance. Chromium supplementation of young men and women does not promote muscle accretion, fat loss, or gains in strength. Physically active individuals with concerns about meeting guidelines for nutrient intake should be counseled to select and consume foods with high nutrient densities rather than to rely on nutritional supplements.
 Materials and Methods: Chromium picolinate mediated with ZnO nanoparticles were evaluated for its antibacterial activity and cytotoxicity potential using brine shrimp lethality assay.
 Results: Chromium picolinate mediated zinc oxide nanoparticles show good results in antimicrobial activity as well as in cytotoxicity.
 Conclusion: Chromium picolinate mediated Zn nanoparticles is an efficient antibacterial and a potential cytotoxicity agent.

Anti-inflammatory Activity of Selenium Nanoparticles Synthesised Using Pterocarpus santalinus

“…These compounds have been shown to suppress TNF-5-007 and have also demonstrated antiproliferative effects.Many experiments have carried out this activity, but with other nanoparticles such as copper, silver, etc. [29][30][31]. The benefit of the Selenium nanoparticle is that it is cost-effective, produces high reactions and consumes less time.In ancient cultures, physicians relied on herbs to improve the body's immune systems.…”

In-Vitro Antioxidant Potential of Beta-Sitosterol: A Preface

“…We determined the overall antioxidant capability of beta-sitosterol using a specific method [9]. We prepared 0.3 ml of the sample at different concentrations (ranging from 0.5 to 3 mg/ml).…”

Antibacterial potential of inulinase enzyme obtained from Nocardiopsis sp.

“…[ 13 ] Previously, our team has had extensive experience in working on various research projects across multiple disciplines involving the use of various compounds obtained from natural products and evaluating their biological importance. [ 14 15 16 17 18 19 20 21 22 23 ] In industries, microbes like actinobacteria have been used for high yield of enzyme inulinase due to easy growth and high yield in a short time. [ 24 25 26 27 ] Furthermore, marine actinobacteria have extensive bioactive applications such as antibacterial, antioxidant, anticancer, antifungal, antiviral, insecticidal, and antidiabetics has drawn global attention in the past several decades.…”