Cytotoxicity and Oral Acute Toxicity Studies of Lantana camara Leaf Extract

Pour, Badakhshan Mahdi; Latha, Lachimanan Yoga; Sasidharan, Sreenivasan

doi:10.3390/molecules16053663

Cited by 61 publications

(32 citation statements)

References 21 publications

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“…However, female mice lost BW after being treated with a single dose of leaf extract in acute toxicity test, while, males lost organ mass, particularly for heart and kidney. The biochemical liver function tests showed significantly elevated TBIL and ALT in the L. camara leaf extract treated female mice group compared with the control group [76].…”

Section: Side Effects and Toxicitymentioning

confidence: 84%

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Chemical Constituents and Pharmacological Activities of Lantana Camara – A Review

Al-Snafi

2019

Asian J Pharm Clin Res

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Objective: The review was designed to investigate the traditional uses, chemical constituents and pharmacological effects of Lantana camara. Methods: In the current review, databases including Web Science, Pub Med, Scopus and Science Direct, were searched to investigate the chemical constituents and pharmacological effects of Lantana camara. Results: The plant contained alkaloids, glycosides, steroids, saponins, flavanoids, coumarins, tannins, carbohydrates, hydroxy anthraquinones, anthraquinone glycosides, proteins, phytosteroids, fixed oils, fats, and triterpinoids. Previous pharmacological studies revealed that Lantana camara possessed antimicrobial, antiparasitic, anxiolytic, gastrointestinal, hypoglycemic, cardiovascular, antioxidant, anticancer, antiinflammatory, analgesic, wound healing, antiurolithiatic, hepatoprotective, reproductive, anti–hemorrhoidal, thrombin inhibition and many other effects. Conclusion: Lantana camara represents a promising medicinal plant with a wide range of pharmacological activities that could be utilized in several medical applications because of its effectiveness and safety.

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Section: Side Effects and Toxicitymentioning

confidence: 84%

“…The results showed that leaf extract at concentrations up to 500 µg/ml inhibited the growth of cells (2.5 times less than did Triton 100×1%). The cytotoxicity was declined when the concentrations of the extract were elevated [76].…”

Section: Anticancer Effectsmentioning

confidence: 99%

Chemical Constituents and Pharmacological Activities of Lantana Camara – A Review

Al-Snafi

2019

Asian J Pharm Clin Res

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“…Ethanolic and aqueous extract of leaves of V. negundo shows antitumor effect against Dalton's Ascitic Lymphoma (DAL) in Swiss Albino mice [35]. Pour et al, (2011) reported that the methanolic extract of L. camara was studied for its cytotoxicity and oral acute toxicity [36]. Against Dalton's ascetic lymphoma, leukemia and many cancer cell lines, B. variegata stem was shown to have cytotoxic activity.…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

V. Negundo, L. Camara and B. Variegata Plants Leaf Extract Exhibit Considerable in Vitro Antioxidant and Anticancer Activities

Badgujar¹,

Mistry

Patel

2017

Int J Pharm Pharm Sci

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Objective: The study was planned to investigate antioxidant and anticancer activities with the preliminary phytochemical analysis of methanolic extracts of Vitex negundo (V. negundo), Lantana camara (L. camara) and Bauhania variegata (B. variegata) plants leaf extracts. Methods:Phytochemical evaluation was performed for all the extracts, as per the standard methods. In vitro antioxidant activities were performed by using DPPH (2,2-Diphenyl-1-Picrylhydrazyl), ABTS (2, 2'-Azino-Bis-3-Ethylbenzothiazoline-6-Sulfonic Acid) and FRAP (Ferric reducing antioxidant power assay) method and compared with standard antioxidants. The anticancer activity of plant extract was assessed using MTT colorimetric assay. Results:The study of preliminary phytochemical proved the existence of alkaloids, flavonoids and phenolic types of phytochemicals in high amount. Methanolic extract of L. camara shows minimum IC50 value for DPPH assay (48.75±2.34 µg/ml) and FRAP assay (274.66±3.65 µg/ml). In ABTS assay B. variegata extract exhibit minimum IC50 value (60.48±3.01 µg/ml). Lower the IC50 value of extract, higher the effectiveness of the plant. Methanolic extract of all plants methanolic extracts showed anticancer activity against SH-SY-5Y cells (human neuroblastoma cell) but V. negundo was more effective against SH-SY-5Y cells with IC50 value (209 µg/ml) compared to remaining extracts. Conclusion:The current finding accomplished the in vitro activities, so that plant could be a superior source of antioxidant and anticancer drugs. But further in vivo assessment was needed before adding it into the pharma industry.

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“…[11] Thus, two doses (low and high), as recommended by Organisation for Economic Co-operation and Development [12] guidelines of 250 and 500mg/kg of compound was suspended in 10% Tween20 and administered by gavage to mice weighing between 25-30g (n=5). The control group received tween 20 alone.…”

Section: Treatmentmentioning

confidence: 99%

Cytotoxicity and Oral Acute Toxicity Studies of b-mangostin Isolated from Cratoxylum arborescens

Syam¹,

Bustamam²,

Abdullah³

et al. 2014

Phcog J.

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Introduction:The objective of this study was to investigate the cytotoxicity and oral acute toxicity of β-mangostin isolated from Cratoxylum arborescens. Material and methods: Healthy male and female ICR mice (8 weeks) were fed orally with 250 and 500mg/kg of β-mangostin. Body weight of each animal was measured and any gross behavioral change was observed daily. Hematological and clinical biochemical parameters as well as histopathological analysis were carried out on 15 th day. The level of oxidative stress was analyzed using MDA and GSH measurement. Discussion: The results showed that oral administration of the β-mangostin had no adverse effect on the growth rate, hematological and clinical biochemical parameters. Histological studies showed that the treatments did not induce any pathological changes in the liver and kidney. The compound at both the doses did not alter the oxidative stress biomarkers. The in vitro cytotoxicity of β Mangostin was investigated in HepG2, A549, MCF-7, MDA-MB-231 and PC3 cells. There was significant cytotoxicity in both type of breast cancer cells (MCF-7 and MDA-MB-231).In conclusion, our results show that there was no treatment-related acute toxicity in mice following 14-days oral administration of 250 and 500mg/kg of β-mangostin. Conclusion: The results showed that the compound can be selected for detailed in vitro and in vivo breast cancer research.

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Cytotoxicity and Oral Acute Toxicity Studies of Lantana camara Leaf Extract

Cited by 61 publications

References 21 publications

Chemical Constituents and Pharmacological Activities of Lantana Camara – A Review

Chemical Constituents and Pharmacological Activities of Lantana Camara – A Review

V. Negundo, L. Camara and B. Variegata Plants Leaf Extract Exhibit Considerable in Vitro Antioxidant and Anticancer Activities

Cytotoxicity and Oral Acute Toxicity Studies of b-mangostin Isolated from Cratoxylum arborescens

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