Cytotoxicity of Paclitaxel in Biodegradable Self-Assembled Core-Shell Poly(Lactide-Co-Glycolide Ethylene Oxide Fumarate) Nanoparticles

He, Xuezhong; Ma, Junyu; Mercado, Angel E.; Xu, Weijie; Jabbari, Esmaiel

doi:10.1007/s11095-007-9513-z

Cited by 48 publications

(35 citation statements)

References 51 publications

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“…The rats were scanned every hour for 8 h and 24 h after administration. The intensities were displayed in pseudo colors by the Odyssey software (LI-COR Biosciences) to isolate regions of interest (18). This in vivo study was performed following institutional approval from the Ethics Committee of Adnan Menderes University (Aydýn, Turkey, No: B.30.2.ADU.0.00.00.00/050.04/2012/107).…”

Section: In Vivo Distribution Studiesmentioning

confidence: 99%

Evaluation of chitosan based vaginal bioadhesive gel formulations for antifungal drugs

et al. 2014

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Vaginal yeast infections are among the most common reasons for women seeking medical care; it has been estimated that 70-75 % of women have an episode of Candida vaginitis at least once during their lifetime (1). Local administration of antimicrobial agents has been favored in the treatment of vaginitis because of the numerous side effects of systemically applied drugs. Vaginal dosage forms used for this purpose include solutions, gels, creams, ointments, foams, pessaries, tablets and vaginal inserts (1). To achieve a desirable therapeutic effect, vaginal delivery systems need to have the ability to spread onto the vaginal mucosa surface and guarantee an intimate and prolonged contact at the site of application (2). Therefore, localized mucoadhesive dosage forms The aim of the present study was to evaluate chitosan as a vaginal mucoadhesive gel base for econazole nitrate and miconazole nitrate. To this aim, different types of chitosan with different molecular masses and viscosity properties [low molecular mass chitosan (viscosity: 20,000 mPa s), medium molecular mass chitosan (viscosity: 200,000 mPa s), high molecular mass chitosan (viscosity: 800,000 mPa s)] have been used. First, rheological studies were conducted on chitosan gels. Mechanical, syringeability and mucoadhesive properties of chitosan gels were determined. Release profiles of econazole nitrate and miconazole nitrate from chitosan gels were obtained and evaluated kinetically. In addition, anticandidal activities of formulations were determined. Finally, vaginal retention of chitosan gels in rats was evaluated by in vivo distribution studies. Based on the results, it can be concluded that gels prepared with medium molecular mass chitosan might be effectively used for different antifungal agents in the treatment of vaginal candidiosis, since it has high mucoadhesiveness, suitable mechanical and release properties with good vaginal retention.

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Section: In Vivo Distribution Studiesmentioning

confidence: 99%

Evaluation of chitosan based vaginal bioadhesive gel formulations for antifungal drugs

et al. 2014

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“…The intensities were displayed in pseudo colors by a LI-COR infrared imaging system (ODYSSEY) to isolate regions of interest. 35 In vivo efficacy study of gels containing CsA-loaded SLNs on oral ulcer model Young adult male New Zealand rabbits (36), weighing 2.5-3.0 kg were used, similarly to how they were used in our previous study, to create an oral ulcer model on the gingiva. 36 The observation intervals and the days of histological sample collection were predetermined according to previous data.…”

Section: In Vivo Distribution Of Gels Containing Csa-loaded Slnsmentioning

confidence: 99%

A new approach to the treatment of recurrent aphthous stomatitis with bioadhesive gels containing cyclosporine A solid lipid nanoparticles: in vivo/in vitro examinations

Karavana¹,

Gökçe²,

Rençber³

et al. 2012

IJN

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Aim:To develop a suitable buccal bioadhesive gel formulation containing cyclosporine A solid lipid nanoparticles (CsA SLNs) for the treatment of recurrent aphthous stomatitis. Methods: The suitability of the prepared formulations for buccal application was assessed by means of rheological studies, textural profile analysis, and ex vivo drug-release studies. Plastic flows, typical gel-like spectra, and suitable mechanical properties were obtained from prepared formulations. The retention time was explored in in vivo distribution studies and the effect of the gel containing CsA SLNs on the healing of oral mucosal ulceration was investigated in an animal model. In vivo distribution studies are a very important indicator of the retention time of formulations at the application site. Results: Distribution studies showed that 64.76% ± 8.35% of the formulation coded "F8+SLN" remained on the buccal mucosa 6 hours after application. For the second part of the in vivo experiments, 36 rabbits were separated into three groups: the first group was treated with the gel formulation without the active agent; the second group with the gel formulation containing CsA SLNs; and the third group, used as the control group, received no treatment. Wound healing was established by scoring of the rate of wound healing on Days 3, 6, 9, and 12. Histological observations were made on the same days as the scoring studies. The bioadhesive gel formulation that included CsA SLNs increased the rate of mucosal repair significantly. Conclusion: This study has shown that the bioadhesive gel formulation containing CsA SLNs reported here is a promising candidate for the topical treatment of recurrent aphthous stomatitis.

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“…He et al [145] prepared biodegradable blends of poly(lactide-co-glycolide fumarate) (PLGF) and poly(lactideco-ethylene oxide fumarate) (PLEOF) macromers and selfassembled then into NPs by dialysis (Fig. 3a).…”

Section: Polyethylene Glycol Fumaratementioning

confidence: 99%

Recent advances in surface engineering of superparamagnetic iron oxide nanoparticles for biomedical applications

Mahmoudi

Simchi

Imani

2010

JICS

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Superparamagnetic iron oxide nanoparticles (SPIONs) are promising materials for various biomedical applications including targeted drug delivery and imaging, hyperthermia, magneto-transfections, gene therapy, stem cell tracking, molecular/cellular tracking, magnetic separation technologies (e.g. rapid DNA sequencing), and detection of liver and lymph node metastases. The most recent applications for SPIONs for early detection of inflammatory, cancer, diabetes and atherosclerosis have also increased their popularity in academia. In order to increase the efficacy of SPIONs in the desired applications, especial surface coating/characteristics are required. The aim of this article is to review the surface properties of magnetic nanoparticles upon synthesis and the surface engineering by different coatings. The biological aspects, cytotoxicity, and health risks are addressed. Special emphasis is given to organic and inorganic-based coatings due to their determinant role in biocompatibility or toxicity of the final particles.

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Cytotoxicity of Paclitaxel in Biodegradable Self-Assembled Core-Shell Poly(Lactide-Co-Glycolide Ethylene Oxide Fumarate) Nanoparticles

Cited by 48 publications

References 51 publications

Evaluation of chitosan based vaginal bioadhesive gel formulations for antifungal drugs

Evaluation of chitosan based vaginal bioadhesive gel formulations for antifungal drugs

A new approach to the treatment of recurrent aphthous stomatitis with bioadhesive gels containing cyclosporine A solid lipid nanoparticles: in vivo/in vitro examinations

Recent advances in surface engineering of superparamagnetic iron oxide nanoparticles for biomedical applications

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