D‐Lactic Acidosis Secondary to Exocrine Pancreatic Insufficiency in a Cat

Packer, Rebecca A.; Cohn, Leah A.; Wohlstadter, David R.; Shelton, G. Diane; Naylor, Jonathan M.; Zello, Gordon A.; Ewaschuk, Julia B.; Williams, David A.; Ruaux, Craig G.; O’Brien, Dennis P.

doi:10.1111/j.1939-1676.2005.tb02667.x

Cited by 36 publications

(12 citation statements)

References 21 publications

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“…Our study identified a significant difference in baseline D‐lactate concentrations when comparing CPV dogs (469 ± 173 μM) to healthy control dogs (306 ± 45 μM), which mirrors the findings of many other studies in human and veterinary medicine that identified differences between healthy and diseased patients . The previous D‐lactate study in CPV dogs obtained higher concentrations for both CPV and control dogs when compared to other species, and CPV dogs actually had lower D‐lactate concentrations (2350 ± 2760 μM) when compared to healthy controls (2690 ± 1830 μM) .…”

Section: Discussionsupporting

confidence: 85%

“…Clinical signs reported in people with increased blood concentrations of D‐lactate include ataxia, mental depression, and metabolic acidosis . Similar findings of D‐lactic acidosis have been reported in young ruminants as well as cats with gastrointestinal disease . Increased D‐lactate concentrations could be present in CPV dogs considering the destruction of the protective intestinal epithelium, resultant maldigestion, risk of bacterial translocation, and the ability for systemic absorption of increased D‐lactate via MCT1 transporters in the colon.…”

Section: Introductionsupporting

confidence: 60%

“…One limitation of that study was an inability to determine trends in D‐lactate during hospitalization. Additionally, when using reference intervals established by numerous studies across monogastric and ruminant species, D‐lactate concentrations in both healthy and CPV dogs equated to concentrations high enough to be considered as being within an abnormal range . Because of these irregularities, additional information regarding the clinical relevance of D‐lactate in the pathogenesis of CPV is warranted.…”

Section: Introductionmentioning

confidence: 99%

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Serum D‐lactate concentrations in dogs with parvoviral enteritis

Venn

Barnes

Hansen

et al. 2020

Veterinary Internal Medicne

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Background Dogs infected with canine parvovirus (CPV) have compromised intestinal epithelial barrier integrity. Production of D‐lactate by enteric bacteria may directly reflect disease severity or contribute to metabolic acid‐base status in these dogs. Hypothesis Serum D‐lactate concentration will be increased in CPV dogs compared to healthy controls and correlate with markers of disease severity and acid‐base status. Animals Dogs with CPV undergoing treatment (n = 40) and healthy control dogs (n = 9). Methods Prospective observational study. Dogs with CPV had a baseline and daily CBC, venous blood gas with serum electrolyte concentrations, composite clinical severity score, and serum D‐lactate concentration performed. A single serum D‐lactate measurement was obtained from healthy control dogs. Results The CPV dogs had a higher D‐lactate concentration (mean ± SD) of 469 ± 173 μM compared to controls, 306 ± 45 μM (P < .001). There was no difference in baseline D‐lactate concentrations for CPV survivors (474 ± 28 μM), versus nonsurvivors (424 ± 116 μM; P = .70). D‐lactate concentration decreased over the first 4 days of treatment (−9.6 μM/d; P = .46). Dogs hospitalized for <4 days had lower baseline D‐lactate concentrations compared to those hospitalized ≥4 days (400 ± 178 μM versus 520 ± 152 μM; P = .03). No sustained correlation over time between serum D‐lactate concentration and clinical severity score or recorded acid‐base results. Conclusions and Clinical Importance Serum D‐lactate concentrations are higher in dogs with CPV compared to healthy controls but do not appear to be clinically relevant. No relationship identified between serum D‐lactate concentrations and markers of CPV disease severity, acid‐base status, or outcome.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionsupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

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Serum D‐lactate concentrations in dogs with parvoviral enteritis

Venn

Barnes

Hansen

et al. 2020

Veterinary Internal Medicne

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“…There have been four recent case series and studies describing the clinical presentation, diagnosis and treatment of feline EPI, 11–14 and also a number of individual case reports, 15–17 but these often include little or no histological description of the pancreas, most likely owing to the fact that as most cases of feline EPI are presumed to be a result of chronic pancreatitis few are biopsied as part of diagnostic investigation. The striking appearance of the pancreas in this case has features in common with some forms of PAA and also with pancreatic lipomatous pseudohypertrophy, a rare entity in humans, which, to date, has not been described in any other species.…”

Section: Discussionmentioning

confidence: 99%

Selective fatty replacement of the exocrine pancreas in a domestic shorthair cat: histopathological findings with long-term outcome

Dobromylskyj¹,

Dobromylskyj

2015

Journal of Feline Medicine and Surgery Open Reports

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The clinical, histopathological findings and eventual outcome of a cat with marked and selective fatty replacement of the exocrine pancreas are described in this case report. A 9-year-old female neutered domestic shorthair cat presenting with polyphagia, weight loss and intermittent vomiting was diagnosed on histopathology with severe exocrine pancreatic atrophy, with relative sparing of the endocrine pancreas and replacement of the acinar cells by mature adipose tissue. This case report discusses the histological findings in this case and the eventual outcome, as well as the potential underlying causes of this histological change.

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“…Os valores de lactato sérico utilizados para cães adultos saudáveis variam de 0,3 a 2,5mmol/L (Hughes et al 1999) e para os felinos de 0,5 a 2,0mmol/L (Packer et al 2008). Porém, Rabelo (2008) considerou normais valores até 3,2mmol/L para o lactato sérico em cães.…”

Section: Introductionunclassified

Valores de lactato sérico e sua correlação com parâmetros clínicos de cães saudáveis, mensurados durante atendimento ambulatorial veterinário

et al. 2016

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ABSTRACT.-Franco R.P., Massufaro C.R., Martineli J., Girotto C.H., Hirota I.N., Zache E. & Hataka A. 2016 The measurement of serum lactate is used in the medical routine as a prognosis marker of emergency patients. Its interpretation should not be done disconnectedly from the other clinical parameters once metabolical or environmental stress as well as restraint and/or manipulation of patients can interfere. Thus we tried to measure the levels of serum lactate and clinical parameters of healthy dogs, as their correlation during veterinarian outpatient clinical care. For that we evaluated 80 dogs, males and females, with age ranging from one to eight years, met for polyvalent annual revaccination. We considered to be healthy those dogs that had no clinical events in the last 60 days or alteration in physical exams, blood exam values and serum glycemia. We initially measured body weight, heart rate (HR) and respiratory (RR), capillary refill time, mucosa's coloring, rectal temperature (RT), peripheral temperature (PT) and the difference between RT and PT, Delta T°C. Finally we did the blood exam and the serum glycemia, as well as the serum lactate measurement. For that we used a portable lactimeter, using the blood sample taken from the cephalic vein. Furthermore, when there was correlation between the serum lactate values and the body weight, we divided the dogs according to the calculation of 33 and 66 percentile. Evaluated dogs showed average values of 18.3±12.1 kg of body weight and 3.0±1.9 of age; with HR of 126.6±29.1bpm, RR of 66±24mpm, RT of 38.9±0.4°C, PT of 31.5±1,0°C, Delta T°C of 7.3±1.0°C and serum lactate of 3.2±0.4mmol/L; with the latter showing range of 3.1-3.3mmol/L with 95% of reliability and significant correlation (p<0.05) between its values and the body weight (r=0.6) and the heart rate (r=0.4). The serum lactate values obtained were compared between the dogs' groups according to their body weight, showing distinguished differences between them. Thereby we concluded that the serum lactate values in dogs under outpatient care is 3.2mmol/L, with a trust gap of 3.1-3.3mmol/L, highlighting the influence that HR and body weight can have on its values.INDEX TERMS: Serum lactate, clinical parameters, dogs.

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D‐Lactic Acidosis Secondary to Exocrine Pancreatic Insufficiency in a Cat

Cited by 36 publications

References 21 publications

Serum D‐lactate concentrations in dogs with parvoviral enteritis

Serum D‐lactate concentrations in dogs with parvoviral enteritis

Selective fatty replacement of the exocrine pancreas in a domestic shorthair cat: histopathological findings with long-term outcome

Valores de lactato sérico e sua correlação com parâmetros clínicos de cães saudáveis, mensurados durante atendimento ambulatorial veterinário

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