Daily variation in the concentration of melatonin and 5-methoxytryptophol in the goose pineal gland, retina, and plasma

Zawilska, Jolanta B.; Berezińska, Małgorzata; Rosiak, Jolanta; Vivien-Rœls, B.; Skene, Debra J.; Pévet, Paul; Nowak, Jerzy Z.

doi:10.1016/s0016-6480(03)00269-7

Cited by 24 publications

(14 citation statements)

References 55 publications

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“…In the present investigation, the cAMP accumulation basal and forskolin‐induced was inhibited by melatonin in physiological concentrations (Zawilska et al, 2003). The profile obtained demonstrated a greater melatonin inhibitory effect on embryonic days characterized by low adenylate cyclase activity, such as E8, E12 and PH, diminishing at embryonic days where the activity of this enzyme is higher (E14 − E16).…”

Section: Discussionsupporting

confidence: 56%

Melatonin inhibitory effect on cAMP accumulation in the chick retina development

Sampaio

2008

Intl J of Devlp Neuroscience

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The influence of melatonin on the developmental pattern of functional nicotinic acetylcholine receptors was investigated in embry-onic 8-day-old chick retinal cells in culture. The functional response to acetylcholine was measured in cultured retina cells by microphysiometry. The maximal functional response to acetylcho-line increased 2.7 times between the 4th and 5th day in vitro (DIV4, DIV5), while the Bmax value for [ 125 I]-α-bungarotoxin was reduced. Despite the presence of α8-like immunoreactivity at DIV4, functional responses mediated by α-bungarotoxin-sensitive nicotinic acetylcholine receptors were observed only at DIV5. Mecamyla-mine (100 µM) was essentially without effect at DIV4 and DIV5, while dihydro-ß-erythroidine (10-100 µM) blocked the response to acetylcholine (3.0 nM-2.0 µM) only at DIV4, with no effect at DIV5. Inhibition of melatonin receptors with the antagonist luzindole, or melatonin synthesis by stimulation of D4 dopamine receptors blocked the appearance of the α-bungarotoxin-sensitive response at DIV5. Therefore, α-bungarotoxin-sensitive receptors were expressed in retinal cells as early as at DIV4, but they reacted to acetylcholine only after DIV5. The development of an α-bungaro-toxin-sensitive response is dependent on the production of mela-tonin by the retinal culture. Melatonin, which is produced in a tonic manner by this culture, and is a key hormone in the temporal organization of vertebrates, also potentiates responses mediated by α-bungarotoxin-sensitive receptors in rat vas deferens and cerebellum. This common pattern of action on different cell models that express α-bungarotoxin-sensitive receptors probably reflects a more general mechanism of regulation of these receptors. Correspondence

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Section: Discussionsupporting

confidence: 56%

Melatonin inhibitory effect on cAMP accumulation in the chick retina development

Sampaio

2008

Intl J of Devlp Neuroscience

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“…Therefore, the diurnal rhythms of 5-MTOL, with the highest levels during the photophase, were reported in the pineal organs and in the blood plasma of several species [25,32,34,35,44,45,46,62,63], including the domestic duck [33], whereas daily changes in the 5-MIAA level were described in the pineal organs of only a few species (rainbow trout [25], pigeon [35], Japanese quail [64], rat [65], and golden hamster [66]). Studies on Japanese quail demonstrated the presence and diurnal fluctuations of 5-MIAA in blood plasma and identified the pineal organ as a source of this indole in the circulation [64].…”

Section: Resultsmentioning

confidence: 99%

“…Our knowledge concerning the indole contents in the avian pineal organ is almost exclusively limited to MLT and 5-MTOL, which have been measured in several species by radioimmunoassays [32,33,34]. The data concerning other pineal indoles are only fragmentary [35,36,37].…”

Section: Introductionmentioning

confidence: 99%

Diurnal Profiles of Melatonin Synthesis-Related Indoles, Catecholamines and Their Metabolites in the Duck Pineal Organ

Lewczuk

Ziółkowska

Prusik

et al. 2014

IJMS

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This study characterizes the diurnal profiles of ten melatonin synthesis-related indoles, the quantitative relations between these compounds, and daily variations in the contents of catecholamines and their metabolites in the domestic duck pineal organ. Fourteen-week-old birds, which were reared under a 12L:12D cycle, were killed at two-hour intervals. The indole contents were measured using HPLC with fluorescence detection, whereas the levels of catecholamines and their metabolites were measured using HPLC with electrochemical detection. All indole contents, except for tryptophan, showed significant diurnal variations. The 5-hydroxytryptophan level was approximately two-fold higher during the scotophase than during the photophase. The serotonin content increased during the first half of the photophase, remained elevated for approximately 10 h and then rapidly decreased in the middle of the scotophase. N-acetylserotonin showed the most prominent changes, with a more than 15-fold increase at night. The melatonin cycle demonstrated only an approximately 5-fold difference between the peak and nadir. The 5-methoxytryptamine content was markedly elevated during the scotophase. The 5-hydroxyindole acetic acid, 5-hydroxytryptophol, 5-methoxyindole acetic acid and 5-methoxytryptophol profiles were analogous to the serotonin rhythm. The norepinephrine and dopamine contents showed no significant changes. The DOPA, DOPAC and homovanillic acid levels were higher during the scotophase than during the photophase. Vanillylmandelic acid showed the opposite rhythm, with an elevated level during the daytime.

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“…Mel and 5-MTol production is dependent on the overexpression of Hydroxyindole-O-metyl transferase, which may be indirectly responsible for the large increase in circulating antibodies directed against Mel and 5-MTol, synthesized mainly in the pineal gland [36]. Their production obeys a circadian rhythm in healthy persons, which tends to disappear in AD patients [37].…”

Section: Resultsmentioning

confidence: 99%

Circulating Antibodies to IDO/THO Pathway Metabolites in Alzheimer's Disease

Duleu¹,

Mangas

Sevin³

et al. 2010

International Journal of Alzheimer's Disease

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In Alzheimer's disease, indoleamine 2,3-dioxygenase and tryptophan hydroxylase are known to induce an overproduction of neurotoxic compounds, such as quinolinic acid and 3-hydroxykynurenine from the former, and 5-hydroxytryptophol and 5-methoxytryptophol from the latter. Other compounds, such as kynurenic acid, serotonin, and melatonin are produced via the same pathways. An improved ELISA method identified circulating antibodies directed against these compounds, linked to proteins, as previously described for other chronic diseases. This describes how only the A isotype of circulating immunoglobulins recognized a pattern of conjugated tryptophan metabolites in the sera of Alzheimer patients. These data indirectly confirmed the involvement of tryptophan derivatives in the pathogenic processes of Alzheimer's disease. Further studies are required to evaluate the relevance of these antibody patterns in monitoring this disease.

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Daily variation in the concentration of melatonin and 5-methoxytryptophol in the goose pineal gland, retina, and plasma

Cited by 24 publications

References 55 publications

Melatonin inhibitory effect on cAMP accumulation in the chick retina development

Melatonin inhibitory effect on cAMP accumulation in the chick retina development

Diurnal Profiles of Melatonin Synthesis-Related Indoles, Catecholamines and Their Metabolites in the Duck Pineal Organ

Circulating Antibodies to IDO/THO Pathway Metabolites in Alzheimer's Disease

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