Carbon fibre-reinforced polymer (CFRP) composites are used extensively within the marine, oil and gas, aerospace, and automotive industries. In these applications, CFRP components are exposed to a wide range of corrosive substances, such as moisture, saltwater/seawater and industrial oil. As a result, CFRP components inevitably absorb undesirable substances throughout their service life, which subsequently leads to detrimental effects on their mechanical properties. The effects of individual interactions, as well as the sorption of various corrosive substances, is well documented in the literature. However, the combined effects of corrosive media interactions and induced damage to the mechanical performance of CFRP composites is not well known. Within this investigation, the effects of combined substance sorption on the mechanical properties of 2 × 2 twill weave carbon fibrereinforced epoxy, polyester, and vinyl ester composites were compared against the behaviour of individual substance constituents. Three common solutions that CFRP may be exposed to in service are utilised in the current investigation, namely, water, salt water, and industrial hydraulic oil. Gravimetric, tension and flexural tests were undertaken to understand the physical effect of the sorption phenomenon and to quantify the amount of deterioration in the mechanical performance of CFRP under hot and wet conditions. It was found that a combination of water and hydraulic oil, or salt water and hydraulic oil, degraded the CFRP specimens more than any individual solution. Moreover, it was observed that epoxy-based composites were more susceptible to deterioration than polyester-and vinyl ester-based composites. These results are important in developing design guidance for CFRP exposure in different media.