Dangguijakyak-san, a medicinal herbal formula, protects dopaminergic neurons from 6-hydroxydopamine-induced neurotoxicity

Antioxidant Activity of Oral Administration of Rosmarinus Officinalis Leaves Extract on Rat's Hippocampus which Exposed to 6-Hydroxydopamine

“…Antioxidants are expected to have a major impact on the treatment of PD. The natural occurrence of antiparkinsonian drugs in plants: anticholinergics in Datura stramonium, levodopa in Mucuna pruriens and Vicia faba, dopamine agonist activity in Claviceps purpura, and MAO inhibitor activity in Banisteria caapi and Ginkgo biloba leaves extract are known (Hritcu et al 2011;Hwang et al 2011;Song et al 2012;Song SS et al 2012;). Green and black tea extracts attenuated neuronal apoptosis induced by 6-OHDA (Chaturvedi et al 2006;Guo et al 2007;Bitu Pinto et al 2015).…”

“…Our previous reports demonstrated that rats treated with 6-OHDA suffered impairments in memory processes, which are associated with alterations in the brain antioxidant status and lipid peroxidation (Ciobica et al 2012). Consequently, several reports suggested that many plant extracts have neuroprotective activity against 6-OHDA-induced toxicity through antioxidant and antiapoptotic activities in PD models (Hritcu et al 2011;Hwang et al 2011). Oxidative stress results from an imbalance between the cellular production of ROS and antioxidant mechanisms that remove them, although several antioxidant molecules in the brain such as superoxide dismutase (SOD), glutathione peroxidase and ascorbate can remove the ROS (Brieger et al 2012).…”

Neuroprotective effect of the methanolic extract of Hibiscus asper leaves in 6-hydroxydopamine-lesioned rat model of Parkinson's disease

“…To overcome free radical mediated consequences of disease processes and drug therapies, various antioxidant supplements have been proposed and have been shown to play an important role in neuroprotection (Chaturvedi et al, 2006;Datla et al, 2007;Moreira et al, 2010;Hwang et al, 2011). Reports indicate that administration of antioxidants with l-DOPA therapy protects against ROS-induced damage both in vivo and in vitro (Chalimoniuk et al, 2004).…”

“…Our previous reports demonstrated that rats treated with 6-OHDA suffered impairments in memory processes, which are associated with alterations in the brain antioxidant status and lipid peroxidation (Hritcu et al, 2008;Ciobica et al, 2009). Consequently, several reports suggested that many plant extracts have neuroprotective activity against 6-OHDA-induced toxicity through antioxidative and antiapoptotic activities in PD models (RajaSankar et al, 2009;Shim et al, 2009;Moreira et al, 2010;Hwang et al, 2011).…”

Danggui-Shaoyao-San ameliorates cognition deficits and attenuates oxidative stress-related neuronal apoptosis in d-galactose-induced senescent mice

“…For more than thousand years, DSS has been used to improve post-menopausal disorders with neurological symptoms, and regulate hypothalamic-pituitary-endocrine system and immune-neuroendocrine functions in China (Kou et al, 2005;Goto et al, 2009). Recently, many studies have showed that DSS had therapeutic efficacy for senile dementia by enhancing the cognitive behavior (Kou et al, 2002;Hatip-AI-Khatib et al, 2004;Hu et al, 2010), improving the mitochondrial impairment (Kou et al, 2005) and inhibiting neuronal damage (Egashira et al, 2005;Qian et al, 2008;Hwang et al, 2011). These abovementioned findings provide some pharmacological basis for the dementia prevention function of DSS.…”