Dark and photoinduced cytotoxicity of solubilized hydrophobic octa-and hexadecachloro-substituted lutetium(III) phthalocyanines

Gorbunova, Е. А.; Stepanova, Darya; Kosov, Anton D.; Bol’shakova, A. V.; Filatova, N. V.; Sizov, Lev R.; Rybkin, A. Yu.; Спиридонов, В. В.; Sybachin, Andrey V.; Dubinina, Tatiana V.; Милаева, Е. Р.

doi:10.1016/j.jphotochem.2021.113747

Cited by 6 publications

(2 citation statements)

References 46 publications

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“…Mixed micelles effectively solubilize hydrophobic biologically active substances [ 79 , 80 ]. The addition of PTX in a mixture of polylactides in organic solvent in the first stage of preparation of PLAMs allows one to easily control the mass fraction of the incorporated drug and its distribution in micelles.…”

Section: Discussionmentioning

confidence: 99%

Ultrasonic Film Rehydration Synthesis of Mixed Polylactide Micelles for Enzyme-Resistant Drug Delivery Nanovehicles

et al. 2022

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A facile technique for the preparation of mixed polylactide micelles from amorphous poly-D,L-lactide-block-polyethyleneglycol and crystalline amino-terminated poly-L-lactide is described. In comparison to the classical routine solvent substitution method, the ultrasonication assisted formation of polymer micelles allows shortening of the preparation time from several days to 15–20 min. The structure and morphology of mixed micelles were analyzed with the assistance of electron microscopy, dynamic and static light scattering and differential scanning calorimetery. The resulting polymer micelles have a hydrodynamic radius of about 150 nm and a narrow size distribution. The average molecular weight of micelles was found to be 2.1 × 107 and the aggregation number was calculated to be 6000. The obtained biocompatible particles were shown to possess low cytotoxicity, high colloid stability and high stability towards enzymatic hydrolysis. The possible application of mixed polylactide micelles as drug delivery vehicles was studied for the antitumor hydrophobic drug paclitaxel. The lethal concentration (LC50) of paclitaxel encapsulated in polylactide micelles was found to be 42 ± 4 µg/mL—a value equal to the LC50 of paclitaxel in the commercial drug Paclitaxel-Teva.

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Section: Discussionmentioning

confidence: 99%

Ultrasonic Film Rehydration Synthesis of Mixed Polylactide Micelles for Enzyme-Resistant Drug Delivery Nanovehicles

et al. 2022

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“…[1][2][3][4][5] For the hydrophobic BAS, it is important to provide solubility in physiological media. [6] Hydrophilic macromolecules, micelles, nanoparticles, and liposomes represent general classes of carriers that could be used for the encapsulation and delivery of the hydrophobic BAS. [7] Liposomes are traditional biocompatible and biodegradable nanocontainers for the BAS that are capable of incorporating water-insoluble molecules in the area of fatty tails of the lipid bilayer.…”

Section: Introductionmentioning

confidence: 99%

Adsorption of Carboxymethylcyclodextrins on Cationic Liposomes as a Route for Preparation of Capacious Nanocontainers for the Hydrophobic Molecules

Pigareva,

Gorbunova,

Dubinina

et al. 2024

Macromolecular Symposia

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Electrostatic self‐assembly of anionic carboxymethyl cyclodextrins (CMCDs) on the surface of cationic liposomes is investigated. By means of laser microelectrophoresis, dynamic light‐scattering, and atomic force microscopy the structure and composition of interfacial complexes at lipid membrane‐water interphase are analyzed. Incorporation of hydrophobic molecules in CMCDs is studied by UV‐Vis spectroscopy. Liposomes decorated with CMCDs are shown to pose low cytotoxicity up to relatively high concentration – 1 mg mL‐1. The formation of host‐guest complexes between CMCDs and hydrophobic molecules did not affect the adsorption of CMCDs on the liposomal membrane. The electrostatic complexes are found to be stable at physiological ionic strength. Accumulation of CMCDs on cationic liposomes is the promising approach to create capacious nanocontainer for hydrophobic bioactive substances.

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Ensembles of carboxymethyl cyclodextrins on cationic liposomes as highly efficient nanocontainers for the delivery of hydrophobic compounds

Sybachin

Pigareva

2023

Biochimica et Biophysica Acta (BBA) - General Subjects

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Dark and photoinduced cytotoxicity of solubilized hydrophobic octa-and hexadecachloro-substituted lutetium(III) phthalocyanines

Cited by 6 publications

References 46 publications

Ultrasonic Film Rehydration Synthesis of Mixed Polylactide Micelles for Enzyme-Resistant Drug Delivery Nanovehicles

Ultrasonic Film Rehydration Synthesis of Mixed Polylactide Micelles for Enzyme-Resistant Drug Delivery Nanovehicles

Adsorption of Carboxymethylcyclodextrins on Cationic Liposomes as a Route for Preparation of Capacious Nanocontainers for the Hydrophobic Molecules

Ensembles of carboxymethyl cyclodextrins on cationic liposomes as highly efficient nanocontainers for the delivery of hydrophobic compounds

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