Darstellung und struktur α-anionisierter acrylsäurederivate: α-lithiiertes lithium-cinnamat

Acylvinyl and Vinylogous Synthons

“…α-Lithio derivatives of α,β-unsaturated acid salts have also been prepared from halogen−metal exchange of the corresponding α-bromo acids with butyllithium at very low temperature. , Moreover, formation of the α-carbanions of tert -butyl 2-alkenoates 23a has been achieved by fluoride ion-induced desilylation of tert -butyl 2-trimethylsilyl-2-alkenoates 22 . When the desilylation takes place in the presence of an aldehyde, tert -butyl 2-(1-hydroxyalkyl)-2-alkenoates 24 are obtained (Scheme ) …”