Data management of clinical trials during an outbreak of Ebola virus disease

Hossmann, Stefanie; Haynes, Alan G.; Spoerri, Adrian; Diatta, Ibrahima Dina; Aboubacar, Barry; Egger, Matthias; Trelle, Sven

doi:10.1016/j.vaccine.2017.09.094

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Thirty-seven studies met the inclusion criteria (Figure 1): 15 meningitis A [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]; 11 Ebola virus disease [26][27][28][29][30][31][32][33][34][35][36]; eight yellow fever [37][38][39][40][41][42][43][44]; one meningitis A and yellow fever [45]; and two focusing on general vaccination strategies. [46,47] Twenty-eight studies focused on…”

Section: Literature Reviewmentioning

confidence: 99%

"Learn from the lessons and don't forget them": Identifying transferable lessons for COVID-19 from meningitis A, yellow fever, and Ebola virus disease vaccination campaigns

Collins

Westerveld

Nelson

et al. 2021

Preprint

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Introduction: COVID-19 vaccines are now being distributed to low- and middle-income countries (LMICs), with global urgency surrounding national vaccination plans. LMICs have significant experience implementing vaccination campaigns to respond to epidemic threats but are often hindered by chronic health system challenges. We sought to identify transferable lessons for COVID-19 vaccination from the rollout of three vaccines that targeted adult groups in Africa and South America: MenAfriVac (meningitis A); 17D (yellow fever); and rVSV-ZEBOV (Ebola virus disease). Methods: We conducted a rapid literature review and 24 semi-structured interviews with technical experts who had direct implementation experience with the selected vaccines in Africa and South America. We identified barriers, enablers, and key lessons from the literature and from participants&#39 experiences. Interview data were analysed thematically according to seven implementation domains. Results: Participants highlighted multiple components of vaccination campaigns that are instrumental for achieving high coverage. Community engagement is an essential and effective tool, requiring dedicated time, funding and workforce. Involving local health workers is a key enabler, as is collaborating with community leaders to map social groups and tailor vaccination strategies to their needs. Vaccination team recruitment and training strategies need to be enhanced to support vaccination campaigns. Although recognised as challenging, integrating vaccination campaigns with other routine health services can be highly beneficial if well planned and coordinated across health programmes and with communities. Conclusion: As supplies of COVID-19 vaccines become available to LMICs, countries need to prepare to efficiently roll out the vaccine, encourage uptake among eligible groups, and respond to potential community concerns. Lessons from the implementation of these three vaccines that targeted adults in LMICs can be used to inform best practice for COVID-19 and other epidemic vaccination campaigns.

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Section: Literature Reviewmentioning

confidence: 99%

"Learn from the lessons and don't forget them": Identifying transferable lessons for COVID-19 from meningitis A, yellow fever, and Ebola virus disease vaccination campaigns

Collins

Westerveld

Nelson

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Also, performing research during an outbreak presents extra challenges compared to similar research conducted on endemic diseases. Partnerships between researchers and local health authorities need to be quickly and effectively established; local regulatory and ethical approval must be granted for any vaccination trial; ideally local physicians should be recruited to deliver the vaccine and monitor patients; sometimes these factors are additionally complicated by a lack of local infrastructure (power, water, internet access) hampering storage and administration of large batches of vaccine [8,12,13]. A fundamental problem for funding trials for vaccines to emerging epidemic diseases with outbreak potential is that such vaccines are not commercially attractive prior to an outbreak, or during inter-epidemic periods.…”

Section: Introductionmentioning

confidence: 99%

UK vaccines network: Mapping priority pathogens of epidemic potential and vaccine pipeline developments

Noad¹,

Simpson²,

Fooks³

et al. 2019

Vaccine

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a b s t r a c tDuring the 2013-2016 Ebola outbreak in West Africa an expert panel was established on the instructions of the UK Prime Minister to identify priority pathogens for outbreak diseases that had the potential to cause future epidemics. A total of 13 priority pathogens were identified, which led to the prioritisation of spending in emerging diseases vaccine research and development from the UK. This meeting report summarises the process used to develop the UK pathogen priority list, compares it to lists generated by other organisations (World Health Organisation, National Institutes of Allergy and Infectious Diseases) and summarises clinical progress towards the development of vaccines against priority diseases. There is clear technical progress towards the development of vaccines. However, the availability of these vaccines will be dependent on sustained funding for clinical trials and the preparation of clinically acceptable manufactured material during inter-epidemic periods.

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‘Learn from the lessons and don’t forget them’: identifying transferable lessons for COVID-19 from meningitis A, yellow fever and Ebola virus disease vaccination campaigns

et al. 2021

View full text Add to dashboard Cite

IntroductionCOVID-19 vaccines are now being distributed to low- and middle-income countries (LMICs), with global urgency surrounding national vaccination plans. LMICs have significant experience implementing vaccination campaigns to respond to epidemic threats but are often hindered by chronic health system challenges. We sought to identify transferable lessons for COVID-19 vaccination from the rollout of three vaccines that targeted adult groups in Africa and South America: MenAfriVac (meningitis A); 17D (yellow fever) and rVSV-ZEBOV (Ebola virus disease).MethodsWe conducted a rapid literature review and 24 semi-structured interviews with technical experts who had direct implementation experience with the selected vaccines in Africa and South America. We identified barriers, enablers, and key lessons from the literature and from participants’ experiences. Interview data were analysed thematically according to seven implementation domains.ResultsParticipants highlighted multiple components of vaccination campaigns that are instrumental for achieving high coverage. Community engagement is an essential and effective tool, requiring dedicated time, funding and workforce. Involving local health workers is a key enabler, as is collaborating with community leaders to map social groups and tailor vaccination strategies to their needs. Vaccination team recruitment and training strategies need to be enhanced to support vaccination campaigns. Although recognised as challenging, integrating vaccination campaigns with other routine health services can be highly beneficial if well planned and coordinated across health programmes and with communities.ConclusionAs supplies of COVID-19 vaccines become available to LMICs, countries need to prepare to efficiently roll out the vaccine, encourage uptake among eligible groups and respond to potential community concerns. Lessons from the implementation of these three vaccines that targeted adults in LMICs can be used to inform best practice for COVID-19 and other epidemic vaccination campaigns.

show abstract

Data management of clinical trials during an outbreak of Ebola virus disease

Cited by 3 publications

References 6 publications

"Learn from the lessons and don't forget them": Identifying transferable lessons for COVID-19 from meningitis A, yellow fever, and Ebola virus disease vaccination campaigns

"Learn from the lessons and don't forget them": Identifying transferable lessons for COVID-19 from meningitis A, yellow fever, and Ebola virus disease vaccination campaigns

UK vaccines network: Mapping priority pathogens of epidemic potential and vaccine pipeline developments

‘Learn from the lessons and don’t forget them’: identifying transferable lessons for COVID-19 from meningitis A, yellow fever and Ebola virus disease vaccination campaigns

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