DDT/DDE and breast cancer: A meta-analysis

Ingber, Susan Z.; Buser, Melanie C.; Pohl, Hana R.; Abadin, Henry; Murray, Hannah; Scinicariello, Franco

doi:10.1016/j.yrtph.2013.08.021

Cited by 57 publications

(27 citation statements)

References 54 publications

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“…10,23 However, other reports showed that DDE and DDT were not associated with breast cancer. 24,25 In addition, the effects of PCBs on breast cancer are also contentious. 26,27 We consider these different results are attributed to various factors, including differences in region discrepancy, in study designs, in biological matrices used to estimate OC pesticides exposure, and in target populations with highly varied historical and different exposure levels to OC pesticides and distinct races, age groups, and/or dietary patterns.…”

Section: Discussionmentioning

confidence: 99%

Organochlorine pesticides accumulation and breast cancer: A hospital-based case–control study

Zuo

Wang

et al. 2017

Tumour Biol.

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The aim of this study is to detect the accumulation status of organochlorine pesticides in breast cancer patients and to explore the relationship between organochlorine pesticides contamination and breast cancer development. We conducted a hospital-based case-control study in 56 patients with breast cancer and 46 patients with benign breast disease. We detected the accumulation level of several organochlorine pesticides products (β-hexachlorocyclohexane, γ-hexachlorocyclohexane, polychlorinated biphenyls-28, polychlorinated biphenyls-52, pentachlorothioanisole, and pp′-dichlorodiphenyldichloroethane) in breast adipose tissues of all 102 patients using gas chromatography. Thereafter, we examined the expression status of estrogen receptor, progesterone receptor, human epidermal growth factor receptor-2 (HER2), and Ki-67 in 56 breast cancer cases by immunohistochemistry. In addition, we analyzed the risk of breast cancer in those patients with organochlorine pesticides contamination using a logistic regression model. Our data showed that breast cancer patients suffered high accumulation levels of pp′-dichlorodiphenyldichloroethane and polychlorinated biphenyls-52. However, the concentrations of pp′-dichlorodiphenyldichloroethane and polychlorinated biphenyls-52 were not related to clinicopathologic parameters of breast cancer. Further logistic regression analysis showed polychlorinated biphenyls-52 and pp′-dichlorodiphenyldichloroethane were risk factors for breast cancer. Our results provide new evidence on etiology of breast cancer.

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Section: Discussionmentioning

confidence: 99%

Organochlorine pesticides accumulation and breast cancer: A hospital-based case–control study

Zuo

Wang

et al. 2017

Tumour Biol.

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“…15 Additionally, it is important to consider weight and weight change because body mass index (BMI), a surrogate for adiposity, can alter tissue and blood concentrations and can cause slower elimination of organochlorine compounds and thus result in extended exposures in the body. 10 While several studies have found significant associations between DDT, DDE and chlordane and breast cancer incidence, [16][17][18][19][20][21] results of most, [22][23][24][25][26][27] including two meta-analyses, 28,29 have largely been null, possibly because the measurements obtained may not correctly reflect the exposures during the etiologically relevant period(s). Although data on early life exposures are limited, results of a two-generation cohort studies found that blood measures of DDT ascertained prenatally or before a woman's reproductive years were associated with subsequent risk of developing breast cancer 21,30,31 ; however, the role of early life exposures to DDT remains unresolved.…”

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confidence: 99%

Organochlorine insecticides DDT and chlordane in relation to survival following breast cancer

Parada

Wolff

Engel

et al. 2015

Intl Journal of Cancer

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Organochlorine insecticides have been studied extensively in relation to breast cancer incidence and results from two meta-analyses have been null for late-life residues, possibly due to measurement error. Whether these compounds influence survival remains to be fully explored. We examined associations between organochlorine insecticides (p,p’-DDT, its primary metabolite, p,p’-DDE, and chlordane) assessed shortly after diagnosis and survival among women with breast cancer. A population-based sample of women diagnosed with a first primary invasive or in situ breast cancer in 1996–1997 and with available organochlorine blood measures (n=633) were followed for vital status through 2011. After follow-up of 5 and 15 years, we identified 55 and 189 deaths, of which 36 and 74, respectively, were breast cancer-related. Using Cox regression models, we estimated the multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for lipid-adjusted organochlorine concentrations with all-cause and breast cancer-specific mortality. At 5 years after diagnosis, the highest tertile of DDT concentration was associated with all-cause (HR=2.19; 95%CI: 1.02, 4.67) and breast cancer-specific (HR=2.72; 95%CI: 1.04, 7.13) mortality. At 15 years, middle tertile concentrations of DDT (HR=1.42; CI 0.99, 2.06) and chlordane (HR=1.42; 95%CI: 0.94, 2.12) were modestly associated with all-cause and breast cancer-specific mortality. Third tertile DDE concentrations were inversely associated with 15-year all-cause mortality (HR=0.66; 95%CI: 0.44, 0.99). This is the first population-based study in the United States to show that DDT may adversely impact survival following breast cancer diagnosis. Further studies are warranted given the high breast cancer burden and the ubiquity of these chemicals.

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“…Small studies conducted in the early 1990s suggested a link between pesticide exposure and increased risk of breast cancer (Falck et al , 1992; Wolff et al , 1993), although later studies have not confirmed this association (Ingber et al , 2013). Our findings do not support the hypothesis that breast cancer risk might be reduced with lower pesticide exposure as we observed a slightly higher risk of breast cancer in women who usually or always ate organic food compared with women who never ate organic food.…”

Section: Discussionmentioning

confidence: 99%

Organic food consumption and the incidence of cancer in a large prospective study of women in the United Kingdom

et al. 2014

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Background:Organically produced foods are less likely than conventionally produced foods to contain pesticide residues.Methods:We examined the hypothesis that eating organic food may reduce the risk of soft tissue sarcoma, breast cancer, non-Hodgkin lymphoma and other common cancers in a large prospective study of 623 080 middle-aged UK women. Women reported their consumption of organic food and were followed for cancer incidence over the next 9.3 years. Cox regression models were used to estimate adjusted relative risks for cancer incidence by the reported frequency of consumption of organic foods.Results:At baseline, 30%, 63% and 7% of women reported never, sometimes, or usually/always eating organic food, respectively. Consumption of organic food was not associated with a reduction in the incidence of all cancer (n=53 769 cases in total) (RR for usually/always vs never=1.03, 95% confidence interval (CI): 0.99–1.07), soft tissue sarcoma (RR=1.37, 95% CI: 0.82–2.27), or breast cancer (RR=1.09, 95% CI: 1.02–1.15), but was associated for non-Hodgkin lymphoma (RR=0.79, 95% CI: 0.65–0.96).Conclusions:In this large prospective study there was little or no decrease in the incidence of cancer associated with consumption of organic food, except possibly for non-Hodgkin lymphoma.

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DDT/DDE and breast cancer: A meta-analysis

Cited by 57 publications

References 54 publications

Organochlorine pesticides accumulation and breast cancer: A hospital-based case–control study

Organochlorine pesticides accumulation and breast cancer: A hospital-based case–control study

Organochlorine insecticides DDT and chlordane in relation to survival following breast cancer

Organic food consumption and the incidence of cancer in a large prospective study of women in the United Kingdom

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