Decidual macrophage derived MMP3 contributes to extracellular matrix breakdown in spiral artery remodeling in early human pregnancy

Pan, Yue; Yang, Li; Chen, Danyang; Hou, Huomei; Zhang, Min; Chen, Miaojuan; Fang, Ning; Lu, Qin; Zhao, Mingguan; Li, Li; Lash, Gendie E.

doi:10.1016/j.jri.2022.103494

Cited by 9 publications

(6 citation statements)

References 23 publications

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“…It has been proven that decidual macrophages involved in ECM degrading in vascular remodeling are mediated by MMP-3 ( 59 ). Macrophages are an important source of MMP, and inflammatory factors can regulate the expression of macrophage proteases, including MMP ( 16 , 60 ).…”

Section: Mmp and Immune Microenvironment At The Maternal-fetal Interfacementioning

confidence: 99%

Insights into the immunomodulatory regulation of matrix metalloproteinase at the maternal-fetal interface during early pregnancy and pregnancy-related diseases

et al. 2023

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Trophoblast immune cell interactions are central events in the immune microenvironment at the maternal-fetal interface. Their abnormalities are potential causes of various pregnancy complications, including pre-eclampsia and recurrent spontaneous abortion. Matrix metalloproteinase (MMP) is highly homologous, zinc(II)-containing metalloproteinase involved in altered uterine hemodynamics, closely associated with uterine vascular remodeling. However, the interactions between MMP and the immune microenvironment remain unclear. Here we discuss the key roles and potential interplay of MMP with the immune microenvironment in the embryo implantation process and pregnancy-related diseases, which may contribute to understanding the establishment and maintenance of normal pregnancy and providing new therapeutic strategies. Recent studies have shown that several tissue inhibitors of metalloproteinases (TIMPs) effectively prevent invasive vascular disease by modulating the activity of MMP. We summarize the main findings of these studies and suggest the possibility of TIMPs as emerging biomarkers and potential therapeutic targets for a range of complications induced by abnormalities in the immune microenvironment at the maternal-fetal interface. MMP and TIMPs are promising targets for developing new immunotherapies to treat pregnancy-related diseases caused by immune imbalance.

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Section: Mmp and Immune Microenvironment At The Maternal-fetal Interfacementioning

confidence: 99%

Insights into the immunomodulatory regulation of matrix metalloproteinase at the maternal-fetal interface during early pregnancy and pregnancy-related diseases

et al. 2023

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“…[72][73][74][75] This process is crucial for trophoblast invasion, 76,77 antigen presentation, 78 and spiral artery remodeling. 79,80 During spiral artery remodeling, macrophages facilitate angiogenesis and aid in the breakdown of fibronectin and laminin via macrophage derived MMP3. 81,82 Recent studies have shown that recurrent spontaneous abortion is associated with the presence of M1 macrophages, which are abundant in the decidua of spontaneous abortions.…”

Section: Endometrial Macrophagesmentioning

confidence: 99%

“…In early pregnancy, some factors like PD‐1 signaling and soluble human leukocyte antigen G5 (sHLAG5) prompt the differentiation of macrophages from the pro‐inflammatory M1 phenotype to the anti‐inflammatory M2 phenotype, which secrete IL‐10 and TGF‐β1 to maintain an immune‐tolerant microenvironment 72–75 . This process is crucial for trophoblast invasion, 76,77 antigen presentation, 78 and spiral artery remodeling 79,80 . During spiral artery remodeling, macrophages facilitate angiogenesis and aid in the breakdown of fibronectin and laminin via macrophage derived MMP3 81,82 …”

Section: Introductionmentioning

confidence: 99%

Endometrial TGFβ signaling fosters early pregnancy development by remodeling the fetomaternal interface

Parks,

Geng,

Monsivais

2023

American J Rep Immunol

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The endometrium is a unique and highly regenerative tissue with crucial roles during the reproductive lifespan of a woman. As the first site of contact between mother and embryo, the endometrium, and its critical processes of decidualization and immune cell recruitment, play a leading role in the establishment of pregnancy, embryonic development, and reproductive capacity. These integral processes are achieved by the concerted actions of steroid hormones and a myriad of growth factor signaling pathways. This review focuses on the roles of the transforming growth factor β (TGFβ) pathway in the endometrium during the earliest stages of pregnancy through the lens of immune cell regulation and function. We discuss how key ligands in the TGFβ family signal through downstream SMAD transcription factors and ultimately remodel the endometrium into a state suitable for embryo implantation and development. We also focus on the key roles of the TGFβ signaling pathway in recruiting uterine natural killer cells and their collective remodeling of the decidua and spiral arteries. By providing key details about immune cell populations and TGFβ signaling within the endometrium, it is our goal to shed light on the intricate remodeling that is required to achieve a successful pregnancy.

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“…However, during the late luteal phase and early pregnancy, nearly 70 to 90% of endometrial lymphocytes are believed to be uterine-specific NK (uNK) cell variants, and 10-20% are antigen-presenting cells (APCs) such as macrophages and dendritic cells. Human decidual NK cells have been shown to play an essential role in spiral artery remodeling and trophoblast invasion [21], [22]. Peripheral NK cells exhibit strong cytotoxic activity and are involved in the defense against infection and neoplasia.…”

Section: Immunological Processes Of Placental Implantation and Its As...mentioning

confidence: 99%

Molecular Development of Placenta and Its Relationship with Preeclampsia and Fetal Growth Restriction

Putra¹

2022

EJMED

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Preeclampsia (PE) is the leading causes of maternal death worldwide as well as a significant cause of fetal morbidity and mortality, including fetal growth restriction (FGR). The concept that PE and FGR shared a common etiology is widely accepted, i.e., the maladaptive response to the impaired placentation. Normal placentation is the result of dynamic integration of cell proliferation, differentiation, and migration, in which trophoblast cells play a crucial role. Impaired trophoblast invasion into the maternal decidua leads to a decrease in uteroplacental blood flow and changes in intervillous hemodynamic. The dynamic interaction of these process with maladaptive decidual immune response, impaired cytokines and angiogenic factors regulation, and oxidative stress will lead into the clinical manifestation of PE and/or FGR.

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Decidual macrophage derived MMP3 contributes to extracellular matrix breakdown in spiral artery remodeling in early human pregnancy

Cited by 9 publications

References 23 publications

Insights into the immunomodulatory regulation of matrix metalloproteinase at the maternal-fetal interface during early pregnancy and pregnancy-related diseases

Insights into the immunomodulatory regulation of matrix metalloproteinase at the maternal-fetal interface during early pregnancy and pregnancy-related diseases

Endometrial TGFβ signaling fosters early pregnancy development by remodeling the fetomaternal interface

Molecular Development of Placenta and Its Relationship with Preeclampsia and Fetal Growth Restriction

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