2016
DOI: 10.1177/0300985816646433
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Decidualization of Endometriosis in Macaques

Abstract: The decidua is the superficial portion of endometrium that transforms, or decidualizes, under the influence of progesterone to nourish the early embryo during pregnancy. Deciduae outside of the uterus are found in nearly 100% of human pregnancies. This condition known as deciduosis may mimic malignancy, resulting in additional diagnostic procedures that place the mother or baby or both at risk. Deciduosis has been described in both Old and New World nonhuman primates in conjunction with pregnancy and after tre… Show more

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Cited by 13 publications
(11 citation statements)
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“…35 In animals, CD10 expression has been detected in the endometrial stromal and decidual cells of monkeys. 6 However, the uterine stromal cells of cats and rabbits are negative for CD10 according to tests performed using the same monoclonal antibody. 11,46 PR and WT1 are expressed in both normal and neoplastic endometrial stromal cells.…”
Section: Discussionmentioning
confidence: 99%
“…35 In animals, CD10 expression has been detected in the endometrial stromal and decidual cells of monkeys. 6 However, the uterine stromal cells of cats and rabbits are negative for CD10 according to tests performed using the same monoclonal antibody. 11,46 PR and WT1 are expressed in both normal and neoplastic endometrial stromal cells.…”
Section: Discussionmentioning
confidence: 99%
“…Evidence for infertility associated with endometriosis is also described in several animal studies as well as human patients (reviewed in Giudice and Kao, 2004). As shown, for example, by data from IVF (in vitro fertilization) treatment, this is mainly caused by poor ovarian reserve in advanced disease, low oocyte quality, impaired embryo survival, and poor im-plantation capacity, most probably due to adverse effects of peritoneal fluid containing high concentrations of cytokines, growth factors, and activated macrophages in patients with endometriosis (Barnhart et al, 2002;Olivennes, 2003;Taketani et al, 1992). The course of the disease and clinical symptoms with endometriosis are highly variable and closely associated with the nature and distribution of lesions (Fanton et al, 1986;Mounsey et al, 2006).…”
Section: Discussionmentioning
confidence: 94%
“…The incidence of spontaneous endometriosis in a breeding colony of Macaca fascicularis has been reported to be 28.7% ( 63 ) in aging females. Lesions of endometriosis have recently been characterized in long-tailed macaques and involved fibrous adhesions, especially between the omentum and the uterus, liver, spleen, and urinary bladder ( 64 ). The same paper also describes cases where one or both ovaries could not be identified and were suspected to be incorporated or effaced by the fibrous adhesions.…”
Section: Discussionmentioning
confidence: 99%