The relations between major global powers and their less powerful neighbours have been widely discussed in academia and policy research, and concepts such as balance, off-shore balance, interdependence, and asymmetrical interdependence have typically been used to describe the dynamics of these interactions. Because these terms are highly abstract, they fail to capture the full picture of these complex interactions. Terms like balance or off-shore balance can partly explain Myanmar's policy towards big powers, but they cannot convey the delicate 70-year history of the balance, the different tactics and processes in security and economic dimensions, and how Myanmar can successfully balance big powers without jeopardising its independence for 70 years in a world dominated by power politics. Interdependence and asymmetrical interdependence cannot reflect the nature of big-small power relations, especially for Myanmar-China relations. The common assumption that lesser powers are 'lost' in the grand scheme of global affairs and are in a victimised position is oversimplified. Given the aforementioned conceptual ambiguity, this study examines case studies of Myanmar's global relationships and provides a long-term characterisation of major powers' engagement with Myanmar to determine whether a small or medium country like Myanmar can maintain its independence and reap benefits from these interactions.