Deconvolution methods for image deblurring in optical coherence tomography

Liu, Yiheng; Liang, Yanmei; Mu, Guoguang; Zhu, Xing

doi:10.1364/josaa.26.000072

Cited by 70 publications

(43 citation statements)

References 11 publications

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“…To achieve higher and more uniform lateral resolution without image processing, a higher numerical aperture objective can be used along with dynamic focus tracking throughout the penetration depth. 2 Alternatively, image-processing techniques, such as deconvolution 3,4 and inverse scattering, 5 can be used to improve lateral resolution. Additionally, recently a Gabor-based fusion technique demonstrated 2-μm lateral resolution.…”

Section: Introductionmentioning

confidence: 99%

Design of a handheld optical coherence microscopy endoscope

2011

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Abstract. Optical coherence microscopy (OCM) combines coherence gating, high numerical aperture optics, and a fiber-core pinhole to provide high axial and lateral resolution with relatively large depth of imaging. We present a handheld rigid OCM endoscope designed for small animal surgical imaging, with a 6-mm diam tip, 1-mm scan width, and 1-mm imaging depth. X-Y scanning is performed distally with mirrors mounted to micro galvonometer scanners incorporated into the endoscope handle. The endoscope optical design consists of scanning doublets, an afocal Hopkins relay lens system, a 0.4 numerical aperture water immersion objective, and a cover glass. This endoscope can resolve laterally a 1.4-μm line pair feature and has an axial resolution (full width half maximum) of 5.4 μm. Images taken with this endoscope of fresh ex-vivo mouse ovaries show structural features, such as corpus luteum, primary follicles, growing follicles, and fallopian tubes. This rigid handheld OCM endoscope can be useful for a variety of minimally invasive and surgical imaging applications. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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Section: Introductionmentioning

confidence: 99%

Design of a handheld optical coherence microscopy endoscope

2011

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“…(7)]. Liu et al [46] reported twodimensional deconvolution methods to deblur OCT images. Recently, Liu et al [38] reported on the use of an auto-regressive-moving-average spectral analysis technique for obtaining axial super-resolution of the OCT signal.…”

Section: Discussionmentioning

confidence: 99%

Super-resolved thickness maps of thin film phantoms and in vivo visualization of tear film lipid layer using OCT

Santos

Schmetterer²,

Triggs

et al. 2016

Biomed. Opt. Express

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In optical coherence tomography (OCT), the axial resolution is directly linked to the coherence length of the employed light source. It is currently unclear if OCT allows measuring thicknesses below its axial resolution value. To investigate spectral-domain OCT imaging in the super-resolution regime, we derived a signal model and compared it with the experiment. Several island thin film samples of known refractive indices and thicknesses in the range 46 − 163 nm were fabricated and imaged. Reference thickness measurements were performed using a commercial atomic force microscope. In vivo measurements of the tear film were performed in 4 healthy subjects. Our results show that quantitative super-resolved thickness measurement can be performed using OCT. In addition, we report repeatable tear film lipid layer visualization. Our results provide a novel interpretation of the OCT axial resolution limit and open a perspective to deeper extraction of the information hidden in the coherence volume.

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“…The deconvolution algorithms for enhancing the spatial resolution and/or the signal-tonoise ratio (SNR) have been widely studied in various imaging modalities such as X-ray imaging [25], ultrasound imaging [26,27], and optical coherence tomography [28,29]. Deconvolution approaches have recently been investigated in PA imaging in ORPAM and PA computed tomography systems [18,[30][31][32][33][34].…”

Section: Introductionmentioning

confidence: 99%

In vivo deconvolution acoustic-resolution photoacoustic microscopy in three dimensions

Cai¹,

Li²,

Chen³

2016

Biomed. Opt. Express

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Acoustic-resolution photoacoustic microscopy (ARPAM) provides a spatial resolution on the order of tens of micrometers, and is becoming an essential tool for imaging fine structures, such as the subcutaneous microvasculature. High lateral resolution of ARPAM is achieved using high numerical aperture (NA) of acoustic transducer; however, the depth of focus and working distance will be deteriorated correspondingly, thus sacrificing the imaging range and accessible depth. The axial resolution of ARPAM is limited by the transducer's bandwidth. In this work, we develop deconvolution ARPAM (D-ARPAM) in three dimensions that can improve the lateral resolution by 1.8 and 3.7 times and the axial resolution by 1.7 and 2.7 times, depending on the adopted criteria, using a 20-MHz focused transducer without physically increasing its NA and bandwidth. The resolution enhancement in three dimensions by D-ARPAM is also demonstrated by in vivo imaging of the microvasculature of a chick embryo. The proposed D-ARPAM has potential for biomedical imaging that simultaneously requires high spatial resolution, extended imaging range, and long accessible depth.

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Deconvolution methods for image deblurring in optical coherence tomography

Cited by 70 publications

References 11 publications

Design of a handheld optical coherence microscopy endoscope

Design of a handheld optical coherence microscopy endoscope

Super-resolved thickness maps of thin film phantoms and in vivo visualization of tear film lipid layer using OCT

In vivo deconvolution acoustic-resolution photoacoustic microscopy in three dimensions

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