Decrease Corneal Hysteresis in Steroid-Induced Ocular Hypertension: A Case Report

Molinari, Joseph F.

doi:10.7205/milmed-d-12-00492

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…We were concerned that the DEX treatment could possibly have affected corneal stiffness, since a previous study showed that DEX treatment softened the cornea in a patient 39 , leading to an artifactual “change” in measured IOP. Thus, the tonometer was calibrated in six eyes of three mice (one control mouse and two DEX-treated mice).…”

Section: Methodsmentioning

confidence: 99%

The relationship between outflow resistance and trabecular meshwork stiffness in mice

Wang

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et al. 2018

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It has been suggested that common mechanisms may underlie the pathogenesis of primary open-angle glaucoma (POAG) and steroid-induced glaucoma (SIG). The biomechanical properties (stiffness) of the trabecular meshwork (TM) have been shown to differ between POAG patients and unaffected individuals. While features such as ocular hypertension and increased outflow resistance in POAG and SIG have been replicated in mouse models, whether changes of TM stiffness contributes to altered IOP homeostasis remains unknown. We found that outer TM was stiffer than the inner TM and, there was a significant positive correlation between outflow resistance and TM stiffness in mice where conditions are well controlled. This suggests that TM stiffness is intimately involved in establishing outflow resistance, motivating further studies to investigate factors underlying TM biomechanical property regulation. Such factors may play a role in the pathophysiology of ocular hypertension. Additionally, this finding may imply that manipulating TM may be a promising approach to restore normal outflow dynamics in glaucoma. Further, novel technologies are being developed to measure ocular tissue stiffness in situ. Thus, the changes of TM stiffness might be a surrogate marker to help in diagnosing altered conventional outflow pathway function if those technologies could be adapted to TM.

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Section: Methodsmentioning

confidence: 99%

The relationship between outflow resistance and trabecular meshwork stiffness in mice

Wang

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et al. 2018

Sci Rep

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Tobramycin/dexamethasone

2015

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S Tobramycin/dexamethasone Ocular hypertension with decreased corneal hysteresis: case reportA 62-year-old man developed ocular hypertension with decreased corneal hysteresis (CH) while receiving tobramycin/ dexamethasone [Tobradex].The man had a history of osteoarthritis, hyperlipidaemia, hypertension and compound hyperopic astigmatism with presbyopia. He reported mattering of his eyes in the morning, and he was diagnosed with rosaceous meibomitis. He started receiving treatment with warm soaks and topical tobramycin/ dexamethasone ointment applied to his lids at night [dose not stated]. He later returned to the clinic [time to reaction onset not stated]. The following ocular response analyser (ORA) readings were found: OD intraocular pressure (IOP)/cc 32.4, IOP/g 28.1 and CH 5.2, and OS IOP/cc 40.7, IOP/g 36.7 and CH 6.0. His IOP had increased 76% and 124% in his right and left eyes, respectively. His CH had decreased 41% in his right eye and 30% in his left eye. He was diagnosed with corticosteroid ocular hypertension.Tobramycin/dexamethasone was withdrawn. One month later, his IOPs had decreased and his CH reading had increased. At last follow-up, the following ORA readings were found: OD IOP/cc 17.9, IOP/g 15.4 and CH 8.7, and OS IOP/ cc 18.9, IOP/g 16.7 and CH 8.6.Author comment: "The patient then developed bilateral increased IOP coupled with decreased corneal stiffness detected by the [ocular response analyser] as a consequence of the topical treatment provided." Molinari JF. Decrease corneal hysteresis in steroid-induced ocular hypertension: a case report. Military Medicine 178: e862-e864, No. 7,

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Decrease Corneal Hysteresis in Steroid-Induced Ocular Hypertension: A Case Report

Cited by 2 publications

References 7 publications

The relationship between outflow resistance and trabecular meshwork stiffness in mice

The relationship between outflow resistance and trabecular meshwork stiffness in mice

Tobramycin/dexamethasone

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