Decreased central histamine in the amygdaloid kindling rats

Toyota, Hiroshi; Ito, Chihiro; Ohsawa, Mariko; Sakurai, Eiko; Sato, Mitsumoto; Watanabe, Takehiko

doi:10.1016/s0006-8993(98)00637-4

Cited by 16 publications

(11 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It seems that lower endogenous levels of histamine in the brain stimulated the susceptibility of acquired amygdaloid kindled seizures [6,15]. Our recent preliminary study also showed that low histamine dietary treatments for 2-week periods enhanced the development of PTZinduced kindled seizures [unpubl.…”

Section: Discussionmentioning

confidence: 96%

“…Several H 1 -receptor antagonists including diphenhydramine and chlorpheniramine were shown to increase focal and general epileptic discharges in both epileptic patients and rodents [7,13]. Recently, decreased histamine levels have been reported in the amygdala of the amygdaloid kindling rats [6,15]. On the other hand, exogenous treatment of histamine, histidine and metoprine which results in an increase of brain hista- Zhang/Chen/Huang/Hu/Wei/Yanai mine has anticonvulsant effects on maximal electrical seizure (MES) and amygdaloid kindling in rodents [5,16,22].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Endogenous Histamine on Seizure Development of Pentylenetetrazole-Induced Kindling in Rats

et al. 2003

View full text Add to dashboard Cite

This study was performed to investigate whether or not endogenous histamine can protect seizure development of pentylenetetrazole (PTZ)-induced kindling in rats. An intracerebroventricular (i.c.v.) injection with clobenpropit (5 and 10 µg), a representative H₃-antagonist, significantly prolonged the onset of kindling and inhibited the seizure stages in a dose-dependent manner. Its action was significantly reversed by both immepip (2 µg, i.c.v.), an H₃-agonist, and α-fluoromethylhistidine (α-FMH, 10 µg, i.c.v.), a selective histidine decarboxylase inhibitor. α-FMH (20 µg, i.c.v.) and pyrilamine (1 and 5 mg/kg i.p.), a classical H₁-antagonist, markedly augmented the severity of seizure development of PTZ-induced kindling. Therefore, these results indicate that brain endogenous histamine plays a certain protective role on seizure development of PTZ-induced kindling in rats, and that its protective roles are mediated by H₁-receptors.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Effects of Endogenous Histamine on Seizure Development of Pentylenetetrazole-Induced Kindling in Rats

et al. 2003

View full text Add to dashboard Cite

show abstract

“…PTZ kindling is the animal model for human primary generalized (or absence) epilepsy. Our data at least suggest that the chronic development of this epileptic seizure is different from the acute one [16] , and other epilepsy styles, such as temporal lobe epilepsy, generalized seizure, and so on [16,17] . At present, we have no explanation for why chronic kindling could increase histamine levels in rats fed with LH diets.…”

Section: Discussionmentioning

confidence: 59%

“…It has been reported that increased histamine levels in the cortex and hypothalamus are induced by PTZ kindling seizures in H1R KO mice [9] , and by maximal electroshock in mice [16] . However, the histamine levels significantly decrease in the amygdala of electrical stimulation site after the development of amygdaloid kindling [6,17,18] and in the cortex and hypothalamus following acute PTZ kindled seizure [16] . These differences might be due to variations in the experimental methods, the species used, drug dosages, or routes of administration.…”

Section: Discussionmentioning

confidence: 99%

Influence of low dietary histamine on the seizure development of chemical kindling induced by pentylenetetrazol in rats1

Jin

Sakurai

Kiso

et al. 2005

Acta Pharmacologica Sinica

Self Cite

View full text Add to dashboard Cite

Aim: To determine the role of dietary low histamine on the seizure development of pentylenetetrazol (PTZ)-induced kindling in rats. Methods: After 14 d of feeding on a low histamine diet (LH, containing 0.145 µmol/g of histamine), the rats were chemically kindled by repeated intraperitoneal injection of a subconvulsant dose of PTZ (35 mg/kg) once every 48 h, and seizure activity of kindling was recorded for 30 min. Histamine in brain samples was analyzed using a high performance liquid chromatography system with a fluorescence spectrofluorometer. Results: The LH diet induced an increase in seizure response (seizure susceptibility) to the first trial of PTZ, and resulted in facilitation of subsequent PTZ kindling process (seizure development). The histamine levels in the cortex, hippocampus, and hypothalamus of LH-treated rats decreased significantly and these changes correlated well with seizure behavior (r = 0.875, 0.651, and 0.796, respectively). In addition, chronic kindled seizures resulted in a significant increase of the histamine content in the cortex and hypothalamus in the LH-fed groups. Conclusion: These findings indicate that the histamine in daily food could influence the brain histaminergic function, and play an important role in regulating seizure susceptibility.

show abstract

“…Even more, studies in histidine decarboxylase-and H 1 receptor-deficient mice indicated that endogenous histamine plays a crucial role not only in amygdaloid kindled seizures but also in the development of amygdaloid kindling [207]. Acquired amygdaloid kindling susceptibility appears associated with reduced histamine synthesis in limbic brain areas [519].…”

Section: Seizuresmentioning

confidence: 99%

Neuropharmacology of Histamine in Brain

Faucard

Schwartz

2007

Handbook of Contemporary Neuropharmacology

View full text Add to dashboard Cite

Histamine is an important neurotransmitter in brain. Histaminergic neurons emanating from the tuberomamillary nucleus in the hypothalamus project diffusely to the whole brain. Histamine acts via stimulation of three receptor subtypes and exerts essentially excitatory effects upon target neurons. The main function of histaminergic neurons is to trigger and maintain wakefulness and pro cognitive responses. Activation of histaminergic neurotransmission in brain is achieved via blockade of H3 receptors, and is currently explored as a treatment of wakefulness and cognitive deficits in several neurological and psychiatric diseases.

show abstract

Decreased central histamine in the amygdaloid kindling rats

Cited by 16 publications

References 30 publications

Effects of Endogenous Histamine on Seizure Development of Pentylenetetrazole-Induced Kindling in Rats

Effects of Endogenous Histamine on Seizure Development of Pentylenetetrazole-Induced Kindling in Rats

Influence of low dietary histamine on the seizure development of chemical kindling induced by pentylenetetrazol in rats1

Neuropharmacology of Histamine in Brain

Contact Info

Product

Resources

About