Decreased frequency of intracellular IFN‐γ producing T cells in whole blood preparations from patients with atopic dermatitis

Abstract

Decreased frequency of intracellular IFN-gamma producing T cells in whole blood preparations from patients with atopic dermatitis.Källström, Eva; Roscher, Ingrid; Andreasson, Annica; Bäck, Ove; Van Hage-Hamsten, MariannePublished in: Experimental Dermatology DOI: 10.1034/j. 1600-0625.2002.110608.x 2002 Link to publication Citation for published version (APA): Källström, E., Roscher, I., Andreasson, A., Bäck, O., & Van Hage-Hamsten, M. (2002). Decreased frequency of intracellular IFN-gamma producing T cells in whole blood preparations from patients with atopic dermatitis. Experimental Dermatology, 11(6), 556-563. https://doi.org/10.1034/j. 1600-0625.2002.110608.x General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. severity and the level of total IgE (r Ω 0.67, P Ͻ 0.05). In conclusion, our e-mail: marianne.van.hage.hamsten/ks.se results support the evidence for a decreased ability of peripheral CD4 π T cells to produce IFN-g among AD patients.

Intracellular production of IL-2, IL-4, IFN-γ, and TNF-α by peripheral blood CD3+ and CD4+ T cells in children with atopic dermatitis

“…The results presented in our report differ from most studies, which demonstrate increased IL-4 production and decreased IFN-γ by PBMC after in vitro polyclonal stimulation in AD patients compared with nonatopic subjects [9,28,29,36]. In contrast, Källström et al [18] showed decreased frequency of intracellular IFN-γ-and IL-4-producing T cells in whole blood preparations from adult patients with AD. Moreover, Fig.…”

The translational revolution and use of biologics in patients with inflammatory skin diseases

“…92 The view of AD as a prototypical T H 2 disease was supported by multiple observations, including increased levels of T H 2 products, 111 relatively reduced antimicrobial peptide (AMP) levels in skin compared with levels seen in patients with psoriasis, 88 and low levels of IFN-g in blood samples from patients with AD. 112 This led to clinical trials in patients with severe AD with recombinant IFN-g, which was suggested to restore the T H 1/T H 2 balance but was effective in only a subset of patients. 113 Although successful in treating patients with psoriasis, 57 disappointing 115 arguing against a major pathogenic role of TNF in patients with AD.…”

Persulphate challenge in female hairdressers with nasal hyperreactivity suggests immune cell, but no IgE reaction

“…A minimum of 3,000 cells was analyzed within the lymphocyte cluster, and the results are expressed as a percentage of cytokine-producing cells in a population of speciWed T helper cells, i.e., CD3 and CD4 positive cells (Källström et al 2002).…”