Decreased growth in angus steers with a short TG-microsatellite allele in the P1 promoter of the growth hormone receptor gene.

Hale, C.S; Herring, William; Shibuya, Hisashi; Lucy, M.C.; Lubahn, Dennis B.; Keisler, D.H.; Johnson, Gary S.

doi:10.2527/2000.7882099x

Cited by 57 publications

(71 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…All of them were located within the P1 promoter for exon 1A : G/C at position -475, C/T (-262), and C/T (-344). The two C/T substitutions were previously reported by Hale et al (2000) as characteristic of B. indicus species.…”

supporting

confidence: 58%

“…Several polymorphic sequences have been identified in the bovine GHR gene (Falaki et al, 1996;Moisio et al, 1998;Chrenek et al, 1998;Aggrey et al, 1999;Ge et al, 1999;Hale et al, 2000). We found a new RFLP in the bovine GHR gene at Fnu4HI/TseI site (Maj and Zwierzchowski, 2002).…”

mentioning

confidence: 60%

“…However, only few authors reported the effects of GHR gene polymorphism on the production traits in cattle. Hale et al (2000) showed a correlation between a microsatellite marker in the P1 promoter of the bovine growth hormone receptor gene and growth rates in young cattle. According to their results the TG 11 GH receptor allele decreased growth rates in Angus steers.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Single nucleotide polymorphism (SNP) in the 5'-noncoding region of the bovine growth hormone receptor gene and its association with dairy production traits in Polish Black-and-White cattle

Maj¹,

Strzałkowska²,

Sloniewski³

et al. 2004

CZECH J ANIM SCI

View full text Add to dashboard Cite

ABSTRACT:The effects of cow's genotype for growth hormone receptor (GHR) were determined on milk production traits of the Polish Black-and-White (BW) ca�le. It was shown that GHR genotypes significantly influenced most of the dairy traits studied. Cows of the RFLP-NsiI -/-genotype of GHR produced more milk with higher content of milk components, including fat, protein, and lactose than those with +/+ genotype. The heterozygous +/-genotype at RFLP-AccI appeared superior with respect to two milk composition parameters -gross energy and total solids. The combined GHR genotypes (CGGs) 2213 and 1113 were clearly favourable for most traits under study. Cows carrying the 2213 genotype combination produced daily more fat corrected milk, fat, protein and lactose than other genotypes, and the milk of 2213 and 1113 cows contained significantly more total solids, protein, and fat.

show abstract

supporting

confidence: 58%

mentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Single nucleotide polymorphism (SNP) in the 5'-noncoding region of the bovine growth hormone receptor gene and its association with dairy production traits in Polish Black-and-White cattle

Maj¹,

Strzałkowska²,

Sloniewski³

et al. 2004

CZECH J ANIM SCI

View full text Add to dashboard Cite

show abstract

“…There are several distinct 5 untranslated region (exon 1) variants in mouse (L1-L5) as well as human GHR (V1-V9), and expression of each transcript is regulated by a different promoter (Edens & Talamantes 1998, Menon et al 2001. Several polymorphisms in the promoter region of GHR gene were reported in species including humans (Hadjiyannakis et al 2001), Angus steers (Hale et al 2000) and Angus cattle (Ge et al 2003), although hitherto there has been no report in mice. Interestingly, the polymorphisms in humans located at 87 bp upstream of V9 (Hadjiyannakis et al 2001), homologous to mouse L3, correspond to those we found in mice.…”

Section: Figurementioning

confidence: 99%

Genetic differences in the IGF-I gene among inbred strains of mice with different serum IGF-I levels

Iida¹,

Rosen²,

Ackert‐Bicknell³

et al. 2005

Journal of Endocrinology

View full text Add to dashboard Cite

There is significant heterogeneity in serum IGF-I concentrations among normal healthy individuals across all ages and among inbred strains of mice. C3H/HeJ (C3H) mice have 30% higher serum IGF-I concentrations over a lifetime than C57BL/6J (B6), even though body size and length are identical. The underlying mechanism for this disparity remains unknown although several possibilities exist including altered GH secretion, resistance to GH action, or impaired IGF-I secretion from the liver or peripheral tissues. To study this further, we evaluated mRNA levels of pituitary GH, and of IGF-I, GH receptor (GHR) and acid-labile subunit (ALS) in liver and skeletal muscle of male C3H and B6 strains. mRNA levels of hepatic IGF-I paralleled serum IGF-I levels, whereas pituitary GH mRNA expression was significantly lower in C3H than B6. In addition, reduced hepatic mRNA levels of ALS and GHR in B6 suggests hepatic GH resistance in B6. In contrast, mRNA levels of IGF-I and GHR in skeletal muscle were not different between B6 and C3H. There was a single sequence repeat polymorphism (SSR) in the promoter region of both GHR and IGF-I genes in mice; the SSR in the IGF-I gene was significantly different between the two strains. The SSR in the IGF-I gene corresponds to the E2F binding site, which is critical for regulating IGF-I gene expression. These results suggest that the SSR in the promoter region of the IGF-I gene may be partially responsible for differences in serum IGF-I levels between B6 and C3H strains.

show abstract

“…Holstein bulls with Alul (+/+) genotype had a higher breeding value for milk fat than Holstein bulls with (-/-) genotype. Hale et al (2000) reported in Angus cattle the presence of the polymorphic TG-repeat microsatellite, which is located 90 bp upstream of a major transcription start site in the GH-R gene. According to their results the (TG) H growth hormone receptor allele decreased growth rates in Angus steers.…”

Section: Introductionmentioning

confidence: 99%

Ligand-binding activity of growth hormone receptor (GH-R) in bulls of different breeds with identified GH-R genotypes

Grochowska¹,

Gajewska²,

Snochowski³

et al. 2002

J. Anim. Feed Sci.

View full text Add to dashboard Cite

The relationship between the ligand-binding activity of growth hormone receptor (GH-R) and polymorphism \nAlul, Accl and Stul sites in the 5' flanking region of bovine GH-R gene was examined. The study was performed on twenty six 15-month old bulls of dairy (Friesians) and beef breeds (Charolais, Limousine, Piemontese, Aberdeen Angus, Hereford). Receptor binding capacity (B max ) and dissociation constant (K d ) for GH-R were determined by the Scatchard method. The polymorphism in the GH-R gene was analyzed by PCR-RFLP technique. Our results showed significant differences in the liver GH-R B and K. between the dairy and beef breeds. B was greater (P<0.05)in Polish Friesians as compared to the beef breeds, while K d revealed the lowest figure in the dairy breed (P<0.01). No significant differences were found in the B max and K d values between genotypes within the 5' flanking region of bovine GH-R gene. In conclusion, ligand-binding activity of the liver GH receptors was shown to differ between the dairy and beef bulls. Furthermore, the polymorphism in the 5' regions of GH-R gene seems to have no influence on ligand-binding properties of the liver GH receptor in cattle.

show abstract

Decreased growth in angus steers with a short TG-microsatellite allele in the P1 promoter of the growth hormone receptor gene.

Cited by 57 publications

References 0 publications

Single nucleotide polymorphism (SNP) in the 5'-noncoding region of the bovine growth hormone receptor gene and its association with dairy production traits in Polish Black-and-White cattle

Single nucleotide polymorphism (SNP) in the 5'-noncoding region of the bovine growth hormone receptor gene and its association with dairy production traits in Polish Black-and-White cattle

Genetic differences in the IGF-I gene among inbred strains of mice with different serum IGF-I levels

Ligand-binding activity of growth hormone receptor (GH-R) in bulls of different breeds with identified GH-R genotypes

Contact Info

Product

Resources

About