Decreased serum vitamin D levels in Japanese patients with multiple sclerosis

Niino, Masaaki; Sato, Shinya; Fukazawa, Toshiyuki; Kitajima, Masaki; Miyazaki, Yusei; Matsuse, Dai; Yamasaki, Ryo; Takahashi, Eri; Kikuchi, Seiji; Kira, Jun Ichi

doi:10.1016/j.jneuroim.2015.01.007

Cited by 35 publications

(19 citation statements)

References 33 publications

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“…Whether the lower 25(OH)D levels observed in the CIS patients reflect lower bioavailable VD levels was therefore investigated, but no evidence could be found for this assumption. The similar levels of bioavailable VD are not explained by different DBP levels in patients and HC, which is in line with a recent Japanese study showing equal levels of DBP in HC and patients with relapsing−remitting MS or secondary progressive MS , but contrasts with another recent report on higher DBP levels in HC than in MS patients . Different study populations or different time points in the course of MS might explain these divergent data.…”

Section: Discussionsupporting

confidence: 82%

Low 25‐hydroxyvitamin D, but not the bioavailable fraction of 25‐hydroxyvitamin D, is a risk factor for multiple sclerosis

Behrens

Rasche

Gieß

et al. 2015

Euro J of Neurology

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Lower 25(OH)D3 levels already in the earliest phase of disease and in clinically hardly affected patients suggest that low 25(OH)D3 levels are rather a risk factor for than a consequence of MS. Nevertheless, because bioavailable vitamin D levels did not differ between the two groups, the mechanism underlying the association of 25(OH)D3 and MS does not appear to be related to reduced bioavailability of vitamin D.

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Section: Discussionsupporting

confidence: 82%

Low 25‐hydroxyvitamin D, but not the bioavailable fraction of 25‐hydroxyvitamin D, is a risk factor for multiple sclerosis

Behrens

Rasche

Gieß

et al. 2015

Euro J of Neurology

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“…On the other hand, the mean VDBP level was found to be higher in patients with RRMS (in the remission phase) in another study 22 . We found an inverse correlation between the levels of VDBP and the EDSS in our study, contrary to a previous study in which no association was found between the disability status of the disease, measured by the EDSS, and VDBP 21 . In the study by Delanghe et al 23 , it was asserted that the variation in VDBP genotype may affect the MS risk independently of vitamin D. When all opinions are considered, VDBP may have a complex role in the pathogenesis of MS.…”

Section: Discussioncontrasting

confidence: 99%

“…Smolders et al 20 found no difference in the level of VDBP in patients with RRMS (in relapse and remission phases). Likewise, in a study by Niino et al 21 , no difference in patients with RRMS (in the remission phase) and secondary progressive MS was found. On the other hand, the mean VDBP level was found to be higher in patients with RRMS (in the remission phase) in another study 22 .…”

Section: Discussionmentioning

confidence: 82%

Vitamin D, vitamin D binding protein, vitamin D receptor levels and cardiac dysautonomia in patients with multiple sclerosis: a cross-sectional study

Aktürk

Turan

Tanık

et al. 2019

Arq. Neuro-Psiquiatr.

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Vitamin D is a pleiotropic steroid hormone that modulates the autonomic balance. Its deficiency has been described as an environmental risk factor for multiple sclerosis (MS). The aim of this study was to investigate the serum levels of vitamin D, vitamin D binding protein (VDBP) and vitamin D receptors (VDR) and to evaluate cardiac dysautonomia in MS patients due to bidirectional interaction between vitamin D and the autonomic nervous system. Methods: The current cross-sectional study was conducted on 26 patients with relapsing-remitting MS and on 24 healthy controls. Twenty-four-hour ambulatory blood pressure variability (BPV) was calculated and the participants were evaluated for orthostatic hypotension and supine hypertension. Serum levels of vitamin D, VDBP and VDR were measured. Results: The mean serum vitamin D level was significantly lower in MS patients than in controls (p = 0.044); however there was no significant difference in terms of VDR and VDBP levels between the groups. Supine hypertension and orthostatic hypotension were significant and the 24-hour systolic BPV was significantly decreased in patients with MS (p < 0.05) compared to controls. No correlation was found between vitamin D, VDBP and VDR with supine hypertension, orthostatic hypotension and systolic BPV values (p > 0.05). Also, there was a negative correlation between VDBP and the EDSS (p = 0.039, r = −0.406). Conclusion: There was no correlation between orthostatic hypotension, supine hypertension and systolic BPV values and serum vitamin D, VDBP and VDR in MS patients. Future prospective studies with large number of patients may help us to better understand the relationship between vitamin D and the autonomic nervous system.

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“…In previous Japanese studies, only an effect of latitude on MS susceptibility has been confirmed [3], although other environmental risk factors have not been extensively studied. Recently it has been reported that vitamin D levels were also significantly decreased in MS patients, especially in secondary progressive MS patients, irrespective of latitude; both MS patients residing in Hokkaido and Kyushu islands showed a significant reduction [103,104]. Therefore, vitamin D deficiency may be an environmental susceptibility factor for MS in Japan and may aggravate MS by inducing secondary progression.…”

Section: Other Environmental Factorsmentioning

confidence: 99%

Multiple Sclerosis: Etiology and Mechanism, with Special Reference to Asians

Kira

2016

Neuroimmunological Diseases

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Multiple sclerosis (MS) is a disease that targets myelin in the central nervous system (CNS). It is thought to be an autoimmune disease but this is not yet proven. Genome-wide association studies have revealed many susceptibility genes for MS, and the functions of these genes are mostly immune-related, supporting the autoimmune hypothesis. Increased numbers of T cells showing inter-and intramolecular epitope spreading against myelin proteins; increased cerebrospinal fluid (CSF) levels of interferon (IFN)-γ, interleukin (IL)-17, and downstream pro-inflammatory cytokines; exacerbation of disease following IFN-γ administration; and increased percentages of T helper (Th)1 cells secreting IFN-γ and of Th17 cells secreting IL-17 at relapse all support T-cell involvement in MS lesion formation. B-cell infiltration in the CNS parenchyma is not prominent, while B-cell follicles in the meninges appear to have a close correlation with subpial demyelination, suggesting an involvement of autoantibodies. However, no specific autoantibodies for MS have been detected, although anti-aquaporin-4 antibodies are a specific biomarker for neuromyelitis optica (NMO). We reported the extensive loss of connexins (Cxs) 43, 32, and 47 in acute lesions in patients with Baló's concentric sclerosis, MS, and NMO. Such loss of astroglial and oligodendroglial Cxs could induce widespread disruption of the glial syncytium, leading to failure of energy source transfer. Thus, loss of Cxs in acute MS lesions may contribute to extensive lesion formation. In the Japanese population, HLA-DRB1*0405 is the most common susceptibility allele for non-NMO MS. DRB1*0405 carriers comprise >40 % of all Japanese MS patients, and this proportion is higher in younger generations. HLA-DRB1*0405-positive MS patients show characteristic features, such as younger age at onset, fewer brain lesions, fewer CSF IgG abnormalities, and a slower progression. The recent increase in the number of MS patients in this subgroup may explain the overall decrease in onset age, as shown by the fourth nationwide survey of Japanese MS patients. Therefore, changes in environmental factors may have increased susceptibility to MS in Japanese populations with certain genetic backgrounds.

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Decreased serum vitamin D levels in Japanese patients with multiple sclerosis

Cited by 35 publications

References 33 publications

Low 25‐hydroxyvitamin D, but not the bioavailable fraction of 25‐hydroxyvitamin D, is a risk factor for multiple sclerosis

Low 25‐hydroxyvitamin D, but not the bioavailable fraction of 25‐hydroxyvitamin D, is a risk factor for multiple sclerosis

Vitamin D, vitamin D binding protein, vitamin D receptor levels and cardiac dysautonomia in patients with multiple sclerosis: a cross-sectional study

Multiple Sclerosis: Etiology and Mechanism, with Special Reference to Asians

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