Decreased Type IV Collagenase Activity in Experimental Pancreatic Fibrosis

Ng, E.; Barent, B.; Smith, Gregory S.; Joehl, Raymond J.; Murayama, Kenric M.

doi:10.1006/jsre.2000.6048

Cited by 10 publications

(5 citation statements)

References 20 publications

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“…Imbalance in extracellular matrix homeostasis occurs not only from increased production but also from decreased degradation through an overall decrease in the action of MMPs (54). Expression of the active form of MMP-9 and the activity of MMP-9 and MMP-2 have been shown to decrease initially in a rat model of cerulein-induced acute pancreatitis (54). MMP-2 then also may play a role in resolution of the fibrotic cascade as well.…”

Section: Scarring/fibrosismentioning

confidence: 97%

“…MMPs degrade a variety of extracellular matrix constituents; MMP-1 degrades collagen types I and III, whereas MMP-2 degrades collagen type IV and fibronectin (53). Imbalance in extracellular matrix homeostasis occurs not only from increased production but also from decreased degradation through an overall decrease in the action of MMPs (54). Expression of the active form of MMP-9 and the activity of MMP-9 and MMP-2 have been shown to decrease initially in a rat model of cerulein-induced acute pancreatitis (54).…”

Section: Scarring/fibrosismentioning

confidence: 98%

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Pancreas: Healing response in critical illness

Bentrem

Joehl

2003

Critical Care Medicine

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Inflammatory mediators are responsible for the systemic manifestations of acute pancreatitis and the associated distant organ dysfunction. After the acute injury, regeneration or pancreatic repair is characterized by decreased release of proinflammatory mediators and decreased infiltrating inflammatory cells. Differentiation and proliferation of pancreatic myofibroblasts or "stellate" cells may be responsible for increased extracellular matrix production. The predictable nature in which the inflammation and fibrosis are produced may stimulate novel approaches to disease treatment.

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Section: Scarring/fibrosismentioning

confidence: 97%

Section: Scarring/fibrosismentioning

confidence: 98%

Pancreas: Healing response in critical illness

Bentrem

Joehl

2003

Critical Care Medicine

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“…PSC affect ECM metabolism not only by synthesis but also by matrix degradation. ECM degradation is regulated by the activity of MMP, which consist of collagenases, gelatinases, stromelysis and membrane type MMP 7,37,38 . MMP‐2 and MMP‐9 (gelatinase A and B, respectively) might be important in regulating fibrogenesis and scar degradation.…”

Section: Discussionmentioning

confidence: 99%

Xanthine oxidase‐derived free radicals directly activate rat pancreatic stellate cells

Tanioka¹,

Mizushima²,

Shirahige³

et al. 2006

J of Gastro and Hepatol

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“…che mokine CXCL-8, tran-sform ing growth fac tor-β, in ter leukin 1β -IL1β) makes the ex ami na tion of these en zymes in nu mer ous diseases in ter est ing [10,23]. The fluc tua tions in MMPs ac tivi ties and their natu ral in hibi tors (tis sue in hibi tors of ma trix met al lo pro te inases, TIMPs) were ob served in various liver [9,19,28] and pan creas dis eases [13,17,25].…”

Section: Introductionmentioning

confidence: 99%

“…The role of MMPs in the patho gene sis of CP is the tar get of the se -lected stud ies. The dis tur bances of MMPs ac tiv ity can af fect the ECM re mod el ing and ex ac er bate the in flam matory pro cess within pan creas [25].…”

Section: Introductionmentioning

confidence: 99%

Gelatinase activities and TIMP-2 serum level in alcohol cirrhosis and chronic pancreatitis

Mądro¹,

Kurzepa²,

Czechowska³

et al. 2015

Curr Issues Pharm Med Sci

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There are some divergent data concerning the role of matrix metalloproteinase (MMP)-2, MMP-9 and tissue inhibitor of MMP (TIMP)-2 in the pathogenesis of alcoholic cirrhosis (AC) and chronic pancreatitis (CP). Our objective was to evaluate the activity of MMP-2, MMP-9 and TIMP-2 serum levels in patients with AC and CP. Twenty-one patients with diagnosis of AC and twenty-two with CP admitted to the outpatient clinic for a control visit were enrolled. All results were compared with age and sex-matched control group (n=19). The sera obtained from venous blood were stored at -70°C for further analysis. Activity of MMP-2 and MMP-9 were evaluated with gelatin zymography, TIMP-2 serum level was analyzed with the usage of ELISA method. A significant decrease of serum MMP-2 activity was noted in sera of AC and CP patients in comparison with control. Activity of MMP-9 was elevated only in CP patients and TIMP-2 serum level was elevated only in AC patients. Decreased activity of MMP-2 in AC patients can contribute to cirrhosis development. The high level of MMP-9 in serum related to CP patients theoretically can exacerbate the inflammatory process within the pancreas.

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Decreased Type IV Collagenase Activity in Experimental Pancreatic Fibrosis

Cited by 10 publications

References 20 publications

Pancreas: Healing response in critical illness

Pancreas: Healing response in critical illness

Xanthine oxidase‐derived free radicals directly activate rat pancreatic stellate cells

Gelatinase activities and TIMP-2 serum level in alcohol cirrhosis and chronic pancreatitis

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