Decreasing intradental nerve activity in the cat with potassium and divalent cations

Markowitz, Kenneth; Bilotto, G.; Kim, Sungpyo

doi:10.1016/0003-9969(91)90047-x

Cited by 89 publications

(62 citation statements)

References 31 publications

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“…The resulted elevation in the extracellular [K ϩ ] in the restricted cleft delimited by the neuronal and odontoblast membranes may depolarize the nerve endings and lower threshold for nerve firing in the sensory tract. This could explain why K ϩ -containing agents placed into deep dentinal cavities induce a brief burst of high frequency activity in the intradental nerves (33).…”

Section: Discussionmentioning

confidence: 99%

Characterization and Gene Expression of High Conductance Calcium-activated Potassium Channels Displaying Mechanosensitivity in Human Odontoblasts

Allard¹,

Couble²,

Magloire³

et al. 2000

Journal of Biological Chemistry

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Odontoblasts form a layer of cells responsible for the dentin formation and possibly mediate early stages of sensory processing in teeth. Several classes of ion channels have previously been identified in the odontoblast or pulp cell membrane, and it is suspected that these channels assist in these events. This study was carried out to characterize the K Ca channels on odontoblasts fully differentiated in vitro using the patch clamp technique and to investigate the HSLO gene expression encoding the ␣-subunit of these channels on odontoblasts in vivo. In inside-out patches, K Ca channels were identified on the basis of their K ؉ selectivity, conductance, voltage, and Ca 2؉ dependence. In cell-attached patches, these channels were found to be activated by application of a negative pressure as well as an osmotic shock. By reverse transcription-polymerase chain reaction, a probe complementary to K Ca ␣-subunit mRNA was constructed and used for in situ hybridization on human dental pulp samples. Transcripts were expressed in the odontoblast layer. The use of antibodies showed that the K Ca channels were preferentially detected at the apical pole of the odontoblasts. These channels could be involved in mineralization processes. Their mechanosensitivity suggests that the fluid displacement within dentinal tubules could be transduced into electrical cell signals.

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Section: Discussionmentioning

confidence: 99%

Characterization and Gene Expression of High Conductance Calcium-activated Potassium Channels Displaying Mechanosensitivity in Human Odontoblasts

Allard¹,

Couble²,

Magloire³

et al. 2000

Journal of Biological Chemistry

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“…9 Dentin desensitizers and adhesives are applied to the exposed dentin surfaces to occlude the patent dentinal tubules [10][11] or to depolarize the intradental nerves by dentin desensitizers. [12][13] Recently, one-bottle self-etching adhesives have been developed to greatly simplify the multiple steps of application to one step. Self-etching adhesives might be used to desensitize the DH by reducing dentin permeability.…”

Section: Introductionmentioning

confidence: 99%

Comparative In Vivo Study on the Desensitizing Efficacy of Dentin Desensitizers and One-bottle Self-etching Adhesives

Yu¹,

Liu²,

Jin³

et al. 2010

Operative Dentistry

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Dentin desensitizers and one-bottle self-etching adhesives can significantly reduce dentin hypersensitivity. Clinical desensitizing effectiveness depends on the individual dentin desensitizers/adhesives used. SUMMARYThis in vivo study evaluated the desensitizing efficacy of two one-bottle self-etching adhesives, two dentin desensitizers and a placebo (water). Methods: Thirty-one volunteers with 55 hypersensitive teeth were recruited into this clinical investigation. The sensitive teeth were randomly assigned into five groups and treated with one of the following materials: iBond, Heraeus; Xeno V, Dentsply; Gluma desensitizer, Heraeus; Bifluorid 12, Voco; placebo (water). Mechanical and thermal stimuli were used to assess the tooth sensitivity response. Discomfort interval scale (DIS) scores of the sensitive teeth were recorded at three different investigation times (baseline, immediately and one month after treatment). Impressions were taken from the sensitive teeth at all three different investigation times, and replica models were made for the evaluation of the dentin surfaces by scanning electron microscopy. The Friedman test and the Mann Whitney U-test were used to analyze the data. Results: All dental materials significantly reduced the dentin hypersensitivity immediately (p<0.05) and one month after treatment (p<0.05), with the exception of Bifluorid 12 for mechanical 280Operative Dentistry tooth sensitivity. The placebo (water) only caused a short-term effect on the thermal dentin hypersensitivity (p<0.05). Topical application of the dentin adhesives/desensitizers on sensitive dentinal areas resulted in occlusion of the patent tubules. Conclusions: The one-bottle self-etching adhesives and dentin desensitizers involved in the current clinical investigation could significantly relieve dentin hypersensitivity immediately and over the course of a month after treatment (except for Bifluorid 12 for tooth mechanical sensitivity). The placebo (water) had an immediate effect on thermal dentin hypersensitivity.

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“…41 It is thought that the synapse between the nerve cells is blocked by potassium ions, which will reduce the nerve excitation and the pain associated with it. 42 Various reports about the clinical studies on dentifrice containing potassium have been published. Reports of six studies state that dentifrice which contains either 5% potassium nitrate or 3.75% potassium chloride, decreases DH significantly when it is compared with the baseline or negative controls.…”

Section: Desensitization Of Nerve By Potassium Saltsmentioning

confidence: 99%

Dentin Hypersensitivity: A Review of its Etiology, Mechanism, Prevention Strategies and Recent Advancements in its Management

Farooq¹,

Ali²

2013

World Journal of Dentistry

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Dentinal hypersensitivity is one of the most common clinical problem for which patients seek treatment and visit dental clinics. Its incidence is on a rise probably because its etiology is not very well understood. Once initiated, it can either remain as sensitivity or it can trigger pain and creates severe discomfort for the patient. Number of theories have been put forward to explain the mechanism of hypersensitivity causing pain but hydrodynamic theory is most widely accepted nowadays. Treating dentinal hypersensitivity is a challenge for dental professionals. This article reviews the etiology, mechanism and prevention strategies of dentinal hypersensitivity and also discusses recent advancements in its management.

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Decreasing intradental nerve activity in the cat with potassium and divalent cations

Cited by 89 publications

References 31 publications

Characterization and Gene Expression of High Conductance Calcium-activated Potassium Channels Displaying Mechanosensitivity in Human Odontoblasts

Characterization and Gene Expression of High Conductance Calcium-activated Potassium Channels Displaying Mechanosensitivity in Human Odontoblasts

Comparative In Vivo Study on the Desensitizing Efficacy of Dentin Desensitizers and One-bottle Self-etching Adhesives

Dentin Hypersensitivity: A Review of its Etiology, Mechanism, Prevention Strategies and Recent Advancements in its Management

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