Dedifferentiation of adenoid cystic carcinoma: Report of a case implicating p53 gene mutation

Chau, Yuk Ping; Hongyo, Tadashi; Aozasa, Katsuyuki; Chan, John

doi:10.1053/hupa.2001.28966

Cited by 75 publications

(80 citation statements)

References 14 publications

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“…In the present case, this component was found to be approximately 85% of the area. The high-grade transformed component was the predominant feature in most of the previous cases (10), as in our case.…”

Section: Discussionmentioning

confidence: 49%

“…To our knowledge, there have been only 33 previously reported cases (3,4). The amount of high-grade transformed component in ACC ranges from 10% to 80% (4,10). In the present case, this component was found to be approximately 85% of the area.…”

Section: Discussionmentioning

confidence: 67%

“…Originally, dedifferentiation had been demonstrated in some mesenchymal tumors, such as dedifferentiated chondrosarcoma and dedifferentiated liposarcoma (8,9). This statement has been adapted to salivary malignancies, such as ACC, acinic cell carcinoma, polymorphous low-grade adenocarcinoma, mucoepidermoid carcinoma, and myoepithelial carcinoma (4,10). Some authors recommended the terminology of HGT rather than dedifferentiation (4); however, this is still controversial, because HGT is thought to reflect the actual tumor biology.…”

Section: Discussionmentioning

confidence: 99%

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High-Grade Transformation of Adenoid Cystic Carcinoma Delineated with a Fibrous Rim: A Case Report

Sayar¹,

Sarıoğlu²,

Bakarış³

et al. 2013

Balkan Med J

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Background: High-grade transformation or dedifferentiation in carcinoma is progression of a low-grade malignant neoplasm to a high-grade carcinoma or poorly differentiated adenocarcinoma. This is rarely observed in adenoid cystic carcinoma of the salivary glands.Case Report: A 39 year-old woman presented with a painless mass at the left submandibulary region that had been growing slowly for 5 years. Submandibulary mass resection revealed a mass with peripheral adenoid cystic carcinoma and a central high-grade tumor delineated with a fibrous rim, raising the possibility of a hybrid or composite carcinoma, requiring differential diagnosis depending upon morphology and immunohistochemistry findings. The final histopathological diagnosis was high-grade transformation of adenoid cystic carcinoma. After surgical therapy, the patient was irradiated to the neck and submandibulary region. No sign of tumor recurrence has been evident for 36 months.Conclusion: This present case seems to be another rare case with high-grade transformation of adenoid cystic carcinoma and the fibrous rim may be a histopathological feature of such cases, which should be kept in mind.

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

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High-Grade Transformation of Adenoid Cystic Carcinoma Delineated with a Fibrous Rim: A Case Report

Sayar¹,

Sarıoğlu²,

Bakarış³

et al. 2013

Balkan Med J

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“…Furthermore, the high-grade (''dedifferentiated'') components in ADCC-Ds reported by by Malhotra et al, Chao et al and Moles et al also displayed an absence of myoepithelial differentiation [29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Anaplastic Myoepithelial Carcinoma of the Sinonasal Tract: an Underrecognized Salivary-Type Tumor Among the Sinonasal Small Round Blue Cell Malignancies? Report of One Case and a Review of the Literature

Petersson

Chao

2010

Head and Neck Pathol

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We present a 45 year old female patient with a nasal carcinoma showing high-grade/anaplastic histomorphological features and with a distinct myoepithelial immunohistochemical phenotype including positivity for smooth muscle actin, p63, S100 protein with no sustentacular pattern, calponin, cytokeratin 14, vimentin and cytokeratins (AE1-3 and CK5/6). A minority (\5%) of the cells showed focal and variable immunoreactivity for EMA with no cuticular/canalicular pattern. Bcl-2, CD99, CD117 and CD56 were variously positive, but chromogranin and synaptophysin were negative. Weak to moderate nuclear p53 immunoreactivity was seen in 50% of tumor cells. Mib-1/Ki-67 showed an average proliferation of 60-70%. Fluorescent in situ hybridization revealed no EWS-gene translocation. In situ hybridization for EBER was negative.

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“…Apart from these classic histologic types of adenoid cystic carcinoma, another type, which shows areas of classic adenoid cystic carcinoma with a gradual or sharp transition to areas of high-grade carcinoma has been recently described. To date, about 35 such tumors arising from major and minor salivary glands have been described under different designations, initially as ''hybrid tumors'', between adenoid cystic carcinoma and salivary duct carcinoma [4][5][6][7][8], subsequently as ''dedifferentiated'' adenoid cystic carcinomas [9][10][11][12][13] and most recently as adenoid cystic carcinomas with high-grade transformation [14,15]. The lacrimal gland counterpart of this tumor has, to our knowledge, only been described in two individual case reports [16,17]; two additional cases were included in a recent multiinstitutional histopathologic review of lacrimal gland tumors but not described in detail [2].…”

Section: Introductionmentioning

confidence: 99%

Lacrimal Gland Adenoid Cystic Carcinoma with High-Grade Transformation to Myoepithelial Carcinoma: Report of a Case and Review of Literature

Argyris

Pambuccian

Cayci

et al. 2012

Head and Neck Pathol

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Adenoid cystic carcinoma (AdCC) is the most frequent malignant neoplasm of the lacrimal glands. Like its salivary gland counterpart, lacrimal AdCC can rarely undergo high-grade transformation (''dedifferentiation''). We herein report the clinical, radiographic and microscopic findings of a lacrimal gland AdCC with high grade transformation, occurring in a 39-year-old female patient. In contrast to salivary gland AdCC with high-grade transformation, which usually shows a high grade component with ''ductal'' differentiation, in the case presented, the ''dedifferentiated'' component showed morphologic and immunohistochemical features of myoepithelial differentiation.

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Dedifferentiation of adenoid cystic carcinoma: Report of a case implicating p53 gene mutation

Cited by 75 publications

References 14 publications

High-Grade Transformation of Adenoid Cystic Carcinoma Delineated with a Fibrous Rim: A Case Report

High-Grade Transformation of Adenoid Cystic Carcinoma Delineated with a Fibrous Rim: A Case Report

Anaplastic Myoepithelial Carcinoma of the Sinonasal Tract: an Underrecognized Salivary-Type Tumor Among the Sinonasal Small Round Blue Cell Malignancies? Report of One Case and a Review of the Literature

Lacrimal Gland Adenoid Cystic Carcinoma with High-Grade Transformation to Myoepithelial Carcinoma: Report of a Case and Review of Literature

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