Deep Eutectic Solvents Modified Molecular Imprinted Polymers for Optimized Purification of Chlorogenic Acid from Honeysuckle

Li, Guizhen; Wang, Wei; Wang, Qian; Zhu, Tao

doi:10.1093/chromsci/bmv138

Cited by 23 publications

(32 citation statements)

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“…Regression is a statistical method to verify the linearity of the nonlinear relationship between one or more independent variables and a dependent variable, and is used to study spectrum–effect relationships (Li, Wang, Wang, & Zhu, ; Xie, Zhou, Shi, Li, & Li, ). In this study, ENTER and STEPWISE methods in regression were used to obtain the union results.…”

Section: Methodsmentioning

confidence: 99%

Screening anaphylactoid components of Shuang Huang Lian Injection by analyzing spectrum–effect relationships coupled with UPLC–TOF–MS

Feng

Jing

et al. 2018

Biomedical Chromatography

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Shuang Huang Lian Injection (SHLI) has been used in China for over 30 years as an effective and widely used Chinese herbal prescription to treat acute respiratory infectious. SHLI has, however, caused many severe anaphylactoid reactions. It is important to identify the potential anaphylactoid components of SHLI. Spectrum-effect relationships were used to explore potentially anaphylactoid components. Based on the original herbal formula, honeysuckle, Fructus Forsythiae and Radix Scutellariae extracts were prepared and combined in appropriate proportions. The preparations were then injected into the caudal vein of rats to obtain in vivo serum samples for pharmacological evaluation and fingerprint analysis. The release rate of β-hexosaminidase from RBL-2H cells and plasma histamine level was used as the pharmacological index. Chromatographic fingerprint analysis identified 22 common peaks. Regression analysis and correlation analysis were used to calculate the relationships between the peaks and the pharmacological effects and identified peaks 5, 6, 11, 12 and 17 as likely anaphylactoid agents. The correlated peaks were identified by comparing the fingerprints with in vitro samples and reference standard samples and the structure was identified by UPLC-TOF-MS. This study established a prospective method to clarify the anaphylactoid components in SHLI, which would provide guidances for screening anaphylactoid components in other traditional Chinese medicine injections.

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Section: Methodsmentioning

confidence: 99%

Screening anaphylactoid components of Shuang Huang Lian Injection by analyzing spectrum–effect relationships coupled with UPLC–TOF–MS

Feng

Jing

et al. 2018

Biomedical Chromatography

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“…In 2016, Li et al. prepared DES (synthesized with ChCl)‐modified molecular imprinted polymers (DES‐MIPs), DES‐modified non‐imprinted polymers (DES‐NIPs, without template), MIPs (without DES), and NIPs (without DES and template) in an identical procedure . According to Fig.…”

Section: Preparation Of Deep‐eutectic‐solvent‐based Materialsmentioning

confidence: 99%

“…In recent years, molecularly imprinted polymers (MIPs), exhibiting high selectivity and affinity to the predetermined molecule (template), have attracted increasing interest [38]. [40]. According to Fig.…”

Section: Preparation Of Deep-eutectic-solvent-based Polymersmentioning

confidence: 99%

Development of deep eutectic solvents applied in extraction and separation

Row

2016

J of Separation Science

379

158

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Deep eutectic solvents, as an alternative to ionic liquids, have greener credentials than ionic liquids, and have attracted considerable attention in related chemical research. Deep eutectic solvents have attracted increasing attention in chemistry for the extraction and separation of various target compounds from natural products. This review highlights the preparation of deep eutectic solvents, unique properties of deep eutectic solvents, and synthesis of deep-eutectic-solvent-based materials. On the other hand, application in the extraction and separation of deep eutectic solvents is also included in this report. In this paper, the available data and references in this field are reviewed to summarize the applications and developments of deep eutectic solvents. Based on the development of deep eutectic solvents, an exploitation of new deep eutectic solvents and deep eutectic solvents-based materials is expected to diversify into extraction and separation.

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“…e DESs, including betaine-ethylene glycol [27], choline chloride-ethylene glycol [28,31], choline chloride-caffeic acidethylene glycol [29], and choline chloride-glycerol [30], have been used as porogen to prepare MIPs. Still, it is necessary to further study DESs-MIPs.…”

Section: Preparation and Characterization Of Dess-mipsmentioning

confidence: 99%

“…e DESs can be obtained simply by complexion of quaternary ammonium salts with hydrogen bond donors, which are able to form eutectic mixture. As a result, DESs as porogen have been successfully applied in the synthesis of MIPs, and DESs-MIPs have been used as SPE sorbents [27][28][29][30][31]. However, the application of DESs-MIPs combined with MEPS (DESs-MIPs-MEPS) for extracting levofloxacin from biological samples has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Microextraction by Packed Molecularly Imprinted Polymer Combined Ultra-High-Performance Liquid Chromatography for the Determination of Levofloxacin in Human Plasma

Meng

Wang

2019

Journal of Chemistry

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Fluoroquinolones are considered as gold standard for the prevention of bacterial infections. To improve assessment of antibacterial efficacy, a novel method for determination of levofloxacin was developed and validated. Deep eutectic solvents (DESs) as only green solvent were used as a porogen for preparation of water-compatible molecularly imprinted polymers (MIPs) with a pseudotemplate. The DESs-MIPs were characterized in detail, including scanning electron microscope, nitrogen sorption porosimetry, and Fourier transform-infrared spectra. Clearly, the maximum binding capacity of levofloxacin on DESs-MIPs in water and methanol was 0.216 and 0.077 μmol g−1, respectively. The DESs-MIPs as adsorbing materials were applied in microextraction by packed sorbent (MEPS), and the DESs-MIPs-MEPS conditions were optimized. The DESs-MIPs-MEPS coupled with ultra-high-performance liquid chromatography (UHPLC) was used to determine levofloxacin in human plasma. The method was found linear over 0.05–10 μg mL−1 with coefficient of correlation equal to 0.9988. The limit of detection and limit of quantification were 0.012 and 0.04 μg mL−1, respectively. At three spiked levels, the precision of proposed method was between 95.3% and 99.7% with intraday and interday relative standard deviations ≤8.9%. Finally, the developed method was used to examine levofloxacin from human plasma of 20 hospitalized patients after transrectal ultrasound-guided prostate biopsy, and the average concentration (±SD) of levofloxacin was 2.35 ± 0.99 μg mL−1 in plasma.

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Deep Eutectic Solvents Modified Molecular Imprinted Polymers for Optimized Purification of Chlorogenic Acid from Honeysuckle

Cited by 23 publications

References 50 publications

Screening anaphylactoid components of Shuang Huang Lian Injection by analyzing spectrum–effect relationships coupled with UPLC–TOF–MS

Screening anaphylactoid components of Shuang Huang Lian Injection by analyzing spectrum–effect relationships coupled with UPLC–TOF–MS

Development of deep eutectic solvents applied in extraction and separation

Microextraction by Packed Molecularly Imprinted Polymer Combined Ultra-High-Performance Liquid Chromatography for the Determination of Levofloxacin in Human Plasma

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