Among the most important problems confronted by designers of submarines is to minimize the weight, increase the payload, and enhance the strength of pressure hull in order to sustain the hydrostatic pressure and underwater explosions (UNDEX). In this study, a Multiple Intersecting Cross Elliptical Pressure Hull (MICEPH) subjected to hydrostatic pressure was first optimized to increase the payload according to the design requirements. Thereafter, according to the optimum design results, a numerical analysis for the fluid structure interaction (FSI) phenomena and UNDEX were implemented using nonlinear finite element code ABAQUS/Explicit. The propagation of shock waves through the MICEPH was analyzed and the response modes (breathing, accordion and whipping) were discussed. Furthermore, the acceleration, displacement and failure index time histories at different locations were presented. The results showed that the greatest acceleration occurred in the athwart direction, followed by the vertical and longitudinal directions. Additionally, the first bubble pulse has a major effect on athwart acceleration. Moreover, the analysis can be effectively used to predict and calculate the failure indices of pressure hull. Additionally, it provides an efficient method that reasonably captures the dynamic response of a pressure hull subjected to UNDEX.