Degenerative changes in the cervical spine in Down's syndrome

Tangerud, Åse; Hestnes, Arnulf; Sand, Trond; Sunndalsfoll, S.

doi:10.1111/j.1365-2788.1990.tb01527.x

Cited by 6 publications

(4 citation statements)

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“…The total number of adults with DS studied was large ( N = 1,561), but only three studies utilized controls. Thirteen of the studies used a cohort or case series design (lll), while three used a case‐control design (ll‐2) (Alvarez & Rubin, ; Burke, French, & Roberts, ; Cooke & Lansdall‐Welfare, ; El‐Khouri et al, ; Elliott, Morton, & Whitelaw, ; Ferguson et al, ; French, Burke, Roberts, Whitecloud, & Edmunds, ; MacLachlan et al, ; Miller, Capusten, & Lampard, ; Miller, Grace, & Lampard, ; Morton, Khan, Murray‐Leslie, & Elliott, ; Pueschel et al, ; Pueschel, Scola, & Pezzullo, ; Roy, Baxter, & Roy, ; Tangerud, Hestnes, Sand, & Sunndalsfoll, ; Van Dyke & Gahagan, ) (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…The prevalence of AAI in adults with DS (2–20%) appears to be decreased compared to children with DS (15–20%) but higher than typical age‐matched controls (Alvarez & Rubin, ; Burke et al, ; Cooke & Lansdall‐Welfare, ; El‐Khouri et al, ; Elliott et al, ; Ferguson et al, ; French et al, ; Miller, Capusten, et al, ; Pueschel et al, ; Roy et al, ; Tangerud et al, ). The article with the highest prevalence of AAI (20%) used a cut off of 4 mm which may in part explain the findings (Miller, Capusten, et al, ).…”

Section: Resultsmentioning

confidence: 99%

“…The prevalence of spondylosis or degenerative change of the cervical spine appears to be increased (33–64%) among adults with DS compared to the general population (Burke et al, ; MacLachlan et al, ; Miller, Capusten, et al, ; Tangerud et al, ; Van Dyke & Gahagan, ). These changes often localize to higher levels of the cervical spine and appear to increase in severity with age (Miller, Capusten, et al, ; Tangerud et al, ).…”

Section: Resultsmentioning

confidence: 99%

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Co‐occurring medical conditions in adults with Down syndrome: A systematic review toward the development of health care guidelines

Capone

Chicoine

Bulova

et al. 2017

American J of Med Genetics Pt A

137

136

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Adults with Down syndrome (DS) represent a unique population who are in need of clinical guidelines to address their medical care. The United States Preventive Service Task Force (USPSTF) has developed criteria for prioritizing conditions of public health importance with the potential for providing screening recommendations to improve clinical care. The quality of existing evidence needed to inform clinical guidelines has not been previously reviewed. Using the National Library of Medicine (NLM) database PubMed, we first identified 18 peer reviewed articles that addressed co-occurring medical conditions in adults with DS. Those conditions discussed in over half of the articles were prioritized for further review. Second, we performed detailed literature searches on these specific conditions. To inform the search strategy and review process a series of key questions were formulated a priori. The quality of available evidence was then graded and knowledge gaps were identified. The number of participating adults and the design of clinical studies varied by condition and were often inadequate for answering all of our key questions. We provide data on thyroid disease, cervical spine disease, hearing impairment, overweight-obesity, sleep apnea, congenital heart disease, and osteopenia-osteoporosis. Minimal evidence demonstrates massive gaps in our clinical knowledge that compromises clinical decision-making and management of these medically complex individuals. The development of evidence-based clinical guidance will require an expanded clinical knowledge-base in order to move forward.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Co‐occurring medical conditions in adults with Down syndrome: A systematic review toward the development of health care guidelines

Capone

Chicoine

Bulova

et al. 2017

American J of Med Genetics Pt A

137

136

View full text Add to dashboard Cite

show abstract

“…In two of them there was an atlanto-axial dislocation, but without any corresponding neurological symptoms. However, examination of the X-rays revealed many cases with marked degenerative changes, particularly in the upper part of the cervical spine [19].…”

Section: Role Of Cervical Spine Radiographymentioning

confidence: 99%

Preanesthetic Evaluation and Assessment of Children with Down's Syndrome

Santamaria

Paola

Mafrica

et al. 2007

The Scientific World JOURNAL

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During preoperative evaluation for anesthesia in the Down patient, it is important to focus attention on the functional conditions of the patient and systems that frequently show anomalies. One of the challenges of evaluating pre-operative conditions and potential risks in the Down patient is the lack of a gold-standard evaluation score; cervical spine abnormalities, reduced dimensions and malformations of the airways, neurological changes, respiratory and cardiac disease, as well as endocrinological and metabolic alterations. We suggest, as a possible method of evaluation for patients with mental retardation and possible malformations, a new scale which takes the functional and mental conditions into account: the Sensorial, Psychological, Anatomical, Biological, Operational and Surgical (SPABOS) Compliance Score.

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