Degradation and osteogenic induction of a SrHPO4-coated Mg–Nd–Zn–Zr alloy intramedullary nail in a rat femoral shaft fracture model

Wang, Zhe; Wang, Xinyuan; Tian, Yuan; Jia, Pei; Zhang, Jian; Huang, Junming; Pang, Zhiying; Cao, Yingping; Wang, Xiuhui; An, Shuai; Wang, Xiao; Huang, Hua; Yan, Zuoqin

doi:10.1016/j.biomaterials.2020.119962

Cited by 71 publications

(32 citation statements)

References 63 publications

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“…Furthermore, the newly developed coating led to an improved bone formation and osseointegration after 4 weeks of implantation. Similar results regarding Sr-coated Mgbased alloys were reported by Han et al (2016) and Wang et al (2020). E.g., Han et al (2016) deposited a Sr-Ca-P coating on a Mg-Sr alloy and the results obtained suggested that the coated implant was capable of promoting new bone formation and retard the degradation process.…”

Section: Biological and Biomedical Sciencessupporting

confidence: 83%

“…E.g., Han et al (2016) deposited a Sr-Ca-P coating on a Mg-Sr alloy and the results obtained suggested that the coated implant was capable of promoting new bone formation and retard the degradation process. On the other hand, Wang et al (2020) developed a newly Sr-HPO 4 coating for a Mg-Nd-Zn-Zr alloy and proved that the coating was capable to slow down the corrosion process of the implant and to improve the formation of new bone tissue as well as to enhance fracture healing without causing any side effects in the host. Neacsu et al (2017) deposited a coating based on AC on a newly developed Mg-1Ca-0.2Mn-0.6Zr alloy and the results suggested that the coated alloy was more efficient in promoting bone regeneration in comparison to the bare alloy.…”

Section: Biological and Biomedical Sciencesmentioning

confidence: 99%

“…Compared to the already commercially available Ti, the newly developed Mg screw was free of Al (Ibrahim et al, 2017) and possessed favourable mechanical properties such as a similar elastic modulus to natural bone and improved yielding and tensile strengths. In terms of animal studies, different Mg-based implants have been used in both small and large animal models (Gu et al, 2012;Chaya et al, 2015;Wang et al, 2017;Tian et al, 2018;. However, the studies were mostly rudimentary, lacking the evaluation of the implant in a functional sense.…”

Section: Clinical Applications Of Mg-based Biomaterialsmentioning

confidence: 99%

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In vitro and in vivo biological performance of Mg-based bone implants

Negrescu¹,

Necula²,

Costache³

et al. 2020

Rev. Biol. Biomed. Sci.

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With the rapid advancement of medical technology, it is crucial that a considerable body of biomaterials are taken into consideration and tested for the purpose of bone implant fabrication. Over the last decades degradable metallic materials have attracted increasing interest in the field of hard tissue engineering due to their ability to degrade once they have fulfilled their function, without causing side effects that could potentially be harmful for the human body. In this context, Mg-based biomaterials gained special attention due to their bone-like mechanical properties, good biocompatibility and osteoconductive properties. However, their use in biomedical applications is limited due to their rapid corrosion in physiological environments. Therefore, it is important to reduce the degradation process of these biomaterials for safe biomedical applications. Two main strategies that could potentially lead to a lower corrosion rate are represented by alloying and surface treatment. This review provides a summary of the recent specialized literature concerning Mg-based biomaterials with a special focus on the recent in vitro and in vivo studies regarding Mg-based bone implants.

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Section: Biological and Biomedical Sciencessupporting

confidence: 83%

Section: Biological and Biomedical Sciencesmentioning

confidence: 99%

Section: Clinical Applications Of Mg-based Biomaterialsmentioning

confidence: 99%

See 1 more Smart Citation

In vitro and in vivo biological performance of Mg-based bone implants

Negrescu¹,

Necula²,

Costache³

et al. 2020

Rev. Biol. Biomed. Sci.

View full text Add to dashboard Cite

show abstract

“…all show excellent inherent biocompatibility and osseointegration properties [ 29 , [34] , [35] , [36] ]. Chen et al [ 9 ] and Wang et al [ 37 ] found that the strontium phosphate (including strontium apatite, strontium hydrogen phosphate) coatings on the surface of a magnesium (Mg) alloy can promote proliferation and differentiation of human mesenchymal stem cells and MC3T3E1 cells in vitro, as well as induce further bone formation in vivo. It has also been reported that the Sr-loaded phase-transited lysozyme (PTL) coating invokes greater osteogenesis ability by its effects on the immune environment due to the constant release of Sr ions directly at the implant-tissue interface [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Interleukin-4 assisted calcium-strontium-zinc-phosphate coating induces controllable macrophage polarization and promotes osseointegration on titanium implant

Zhao

Zuo

Wang

et al. 2021

Materials Science and Engineering: C

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Titanium (Ti) and its alloys are believed to be promising scaffold materials for dental and orthopedic implantation due to their ideal mechanical properties and biocompatibility. However, the host immune response always causes implant failures in the clinic. Surface modification of the Ti scaffold is an important factor in this process and has been widely studied to regulate the host immune response and to further promote bone regeneration. In this study, a calcium-strontium-zinc-phosphate (CSZP) coating was fabricated on a Ti implant surface by phosphate chemical conversion (PCC) technique, which modified the surface topography and element constituents. Here, we envisioned an accurate immunomodulation strategy via delivery of interleukin (IL)-4 to promote CSZP-mediated bone regeneration. IL-4 (0 and 40 ng/mL) was used to regulate immune response of macrophages. The mechanical properties, biocompatibility, osteogenesis, and anti-inflammatory properties were evaluated. The results showed that the CSZP coating exhibited a significant enhancement in surface roughness and hydrophilicity, but no obvious changes in proliferation or apoptosis of bone marrow mesenchymal stem cells (BMMSCs) and macrophages. In vitro, the mRNA and protein expression of osteogenic related factors in BMMSCs cultured on a CSZP coating, such as ALP and OCN, were significantly higher than those on bare Ti. In vivo, there was no enhanced bone formation but increased macrophage type 1 (M1) polarization on the CSZP coating. IL-4 could induce M2 polarization and promote osteogenesis of BMMSCs on CSZP in vivo and in vitro. In conclusion, the CSZP coating is an effective scaffold for BMMSCs osteogenesis, and IL-4 presents the additional advantage of modulating the immune response for bone regeneration on the CSZP coating in vivo.

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“…They reported that the bilayer coated Mg-Sr substrate could control the osteoclastogenesis and osteogenesis NF-κB and estrogen receptor α (ERα) signaling pathway and increasing the ratio of receptor activator of nuclear factor kappa-B ligand (RANKL): OPG, the substrate could control the cross talk of osteoclast-osteoblast in co-culture environment using the RANK/RANKL/OPG signaling pathway that could be stimulating the bone remodeling process as shown in Figure 12. Moreover, osteogenic response of biodegradable Mg-Nd-Zn-Zr substrate was stimulated by the Akt/TLR4/PI3K signaling pathway (Wang et al, 2020).…”

Section: Osteointegration Of Coatingsmentioning

confidence: 99%

Magnesium Alloys With Tunable Interfaces as Bone Implant Materials

Rahman

Dutta

Choudhury

2020

Front. Bioeng. Biotechnol.

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Magnesium (Mg) based biodegradable materials are a new generation orthopedic implant materials that are intended to possess same mechanical properties as that of bone. Mg alloys are considered as promising substitutes to permanent implants due to their biodegradability in the physiological environment. However, rapid corrosion rate is one of the major constraints of using Mg alloys in clinical applications in spite of their excellent biocompatibility. Approaches to overcome the limitations include the selection of adequate alloying elements, proper surface treatment, surface modification with coating to control the degradation rate. This review focuses on current advances on surface engineering of Mg based biomaterials for biomedical applications. The review begins with a description of corrosion mechanism of Mg alloy, the requirement for appropriate surface functionalization/coatings, their structure-property-performance relationship, and suitability for biomedical applications. The control of physico-chemical properties such as wettability, surface morphology, surface chemistry, and surface functional groups of the coating tailored by various approaches forms the pivotal part of the review. Chemical surface treatment offers initial protection from corrosion and inorganic coating like hydroxyapatite (HA) improves the biocompatibility of the substrate. Considering the demand of ideal implant materials, multilayer hybrid coatings on Mg alloy in combination with chemical pretreatment or inorganic HA coating, and protein-based polymer coating could be a promising technique to improve corrosion resistance and promote biocompatibility of Mg-based alloys.

show abstract

Degradation and osteogenic induction of a SrHPO4-coated Mg–Nd–Zn–Zr alloy intramedullary nail in a rat femoral shaft fracture model

Cited by 71 publications

References 63 publications

In vitro and in vivo biological performance of Mg-based bone implants

In vitro and in vivo biological performance of Mg-based bone implants

Interleukin-4 assisted calcium-strontium-zinc-phosphate coating induces controllable macrophage polarization and promotes osseointegration on titanium implant

Magnesium Alloys With Tunable Interfaces as Bone Implant Materials

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