Dehydroeffusol Rescues Amyloid β25–35-Induced Spatial Working Memory Deficit

Fukuda, Takuya; Sato, Yuichi; Takiguchi, Mako; Yamamoto, Takahiro; Murasawa, Hiroyasu; Pawlak, Akiko; Kobayashi, Hiroyuki; Tamano, Haruna; Takeda, Atsüshi

doi:10.1007/s11130-020-00816-0

Cited by 10 publications

(1 citation statement)

References 30 publications

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“…The number of arm entries and the number of correct alternations were recorded in order to calculate the percentage of alternations. The alternation behavior percentage (%)was calculated for each group [33,34].…”

Section: Y-maze Testmentioning

confidence: 99%

Short Working Memory Impairment Associated with Hippocampal Microglia Activation in Chronic Hepatic Encephalopathy

El-Mansoury,

Smimih,

El Khiat

et al. 2024

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Hepatic encephalopathy (HE) is a major neuropsychological condition that occursas a result of impaired liver function. It is frequently observed in patients with advanced liver disease or cirrhosis. Memory impairment is among the symptoms of HE; the pathophysiologic mechanism for this enervating condition remains unclear. However, it is possible that neuroinflammation may be involved, as recent studies have emphasized such phenomena. Therefore, the aim of the present study is to assess short working memory (SWM) and examine the involvement of microglia in a chronic model of HE. The study was carried out with male Wistar rats that were induced by repeated thioacetamide (TAA) administration (100 mg/kg i.p injection for 10 days). SWM function was assessed through Y-maze, T-Maze, and novel object recognition (NOR) tests, together with an immunofluorescence study of microglia activation within the hippocampal areas. Our data showed impaired SWM in TAA-treated rats that was associated with microglial activation in the three hippocampal regions, and which contributed to cognitive impairment.

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Section: Y-maze Testmentioning

confidence: 99%