Dehydroepiandrosterone in follicular fluid is produced locally, and levels correlate negatively with in vitro fertilization outcomes

Li, Liyun; Ferin, Michel; Sauer, Mark V.; Løbo, Rogerio A.

doi:10.1016/j.fertnstert.2010.11.007

Cited by 13 publications

(8 citation statements)

References 10 publications

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“…Follicular fluid E2 paralleled serum E2, demonstrating lower values in LE2 donor cycles. The follicular fluid E2 from our LE2 cycles is lower than previously reported normal ranges expected from preovulatory follicles: 530.05 ± 211.56 ng/mL [20] or 301.00-577.00 ng/mL [21]. However, decreased follicular fluid E2 did not correlate with poor fertilization, embryo quality, or pregnancy outcomes, consistent with prior findings by Foong et al [22] Follicular fluid progesterone levels were uniformly high and consistent with previously reported ranges from preovulatory follicles in oocyte donors: 7652 ± 3479 ng/mL [23].…”

Section: Discussioncontrasting

confidence: 73%

Low estradiol responses in oocyte donors undergoing gonadotropin stimulation do not influence clinical outcomes

Palmerola

Rudick

Løbo

2018

J Assist Reprod Genet

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Section: Discussioncontrasting

confidence: 73%

Low estradiol responses in oocyte donors undergoing gonadotropin stimulation do not influence clinical outcomes

Palmerola

Rudick

Løbo

2018

J Assist Reprod Genet

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“…The FF concentrations of hormones, prolactin, interleukin-1, inhibin B, tumour necrosis factor, free fatty acids and dehydroepiandrosterone have been associated with the rates of normal fertilisation and good embryo development and the quality of the embryos [10,18,19]. However, their predictive accuracy and sensitivity is very limited, and some reports did not replicate these findings [20,21].…”

Section: Discussionmentioning

confidence: 99%

Bone morphogenetic protein-15 in follicle fluid combined with age may differentiate between successful and unsuccessful poor ovarian responders

Wang

Chen

et al. 2012

Reprod Biol Endocrinol

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BackgroundThe counselling of poor ovarian responders about the probability of pregnancy remains a puzzle for gynaecologists. The aim of this study was to optimise the management of poor responders by investigating the role of the oocyte-derived factor bone morphogenetic protein-15 (BMP-15) combined with chronological age in the prediction of the outcome of in-vitro fertilisation-embryo transfer (IVF-ET) in poor responders.MethodsA retrospective study conducted in a university hospital. A total of 207 poor ovarian responders who reached the ovum pick-up stage undergoing IVF/intracytoplasmic sperm injection (ICSI) with three or fewer follicles no less than 14 mm on the day of oocyte retrieval were recruited from July 1, 2008 to December 31, 2009. Another 215 coinstantaneous cycles with normal responses were selected as controls. The BMP-15 levels in the follicular fluid (FF) of the 207 poor responders were analysed by western blot. Based on the FF BMP-15 level and age, poor responders were sub-divided into four groups. The main outcome measures were the FF BMP-15 level, implantation rate, pregnancy rate, and live birth rate.ResultsThe implantation rate (24.2% vs. 15.3%), chemical pregnancy rate (40% vs. 23.7%), clinical pregnancy rate (36.5% vs. 20.4%) and live birth rate (29.4% vs. 15.1%) in the high BMP-15 group were significantly higher than those in the low BMP-15 group. Furthermore, poor responders aged less than or equal to 35 years with a higher FF BMP-15 level had the best implantation, pregnancy and live birth rates, which were comparable with those of normal responders.ConclusionsOur study suggests a potential role of BMP-15 in the prediction of the IVF outcome. A high FF BMP-15 combined with an age less than or equal to 35 years may be used as a potential indicator for repeating IVF cycles in poor ovarian responders.

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“…Thus, on the one hand, DHEA is thought to be a key molecule in maintaining the critical balance between androgen and estrogen production, and on the other hand, it affects oocyte maturation. Li and his team found that DHEA in the FF correlated negatively with IVF clinical outcomes, specifically the number of oocytes retrieved, the fertilization rate, the number of viable embryos, and the number of blastocysts produced [19]. Our results showed that the DHEA level in small follicles was increased and correlated negatively with the oocyte maturation rate and the high-quality embryo rate, indicating that DHEA correlates negatively with follicular development, oocyte maturational status and embryo quality.…”

Section: Discussionmentioning

confidence: 54%

Human follicular fluid shows diverse metabolic profiles at different follicle developmental stages

Yang

Feng

et al. 2020

Reprod Biol Endocrinol

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Background: To investigate the metabolic profiles in the follicular fluid (FF) samples from patients undergoing in vitro fertilization (IVF) and to analyze the correlations with follicular development. Methods: The FF samples were obtained from participants (N = 26) who were receiving IVF under the gonadotropin-releasing hormone agonist (GnRH-a) long protocol stimulation and were collected separately from small (8-13 mm) and large (17-22 mm) follicles at the time of oocyte retrieval. Metabolomic analysis of the FF samples was performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Results: The results demonstrated that the size of the follicle influences the metabolic signature of the FF according to the profile and differential metabolites. Dehydroepiandrosterone (DHEA), which is enriched in steroid hormone biosynthesis, correlated negatively with the oocyte maturation rate and the high-quality embryo rate, and thus could be used to estimate the predictive diagnostic potential of follicular development. Conclusion: The FF has different metabolic characteristics in different stages of follicular development. Exploring meaningful metabolites could predict follicular development, and modifications of these metabolites could influence follicular development.

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Dehydroepiandrosterone in follicular fluid is produced locally, and levels correlate negatively with in vitro fertilization outcomes

Cited by 13 publications

References 10 publications

Low estradiol responses in oocyte donors undergoing gonadotropin stimulation do not influence clinical outcomes

Low estradiol responses in oocyte donors undergoing gonadotropin stimulation do not influence clinical outcomes

Bone morphogenetic protein-15 in follicle fluid combined with age may differentiate between successful and unsuccessful poor ovarian responders

Human follicular fluid shows diverse metabolic profiles at different follicle developmental stages

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