Delayed Motherhood Decreases Life Expectancy of Mouse Offspring1

Tarı́n, Juan J.; Gómez-Piquer, Vanessa; Rausell, Francisco; Navarro, Samuel; Hermenegildo, Carlos; Cano, Antonio

doi:10.1095/biolreprod.104.038919

Cited by 45 publications

(47 citation statements)

References 33 publications

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“…The finding of a beneficial effect of young maternal age on offspring survival to age 100 in humans is similarly also reported for laboratory animals (Carnes et al 2012; Tarin et al 2005), and hence may have a biological explanation. There is empirical evidence that the quality of female eggs in humans rapidly declines with age (Bickel 2005; Pellestor et al 2005; Comings and MacMurray 2001; Comings and MacMurray 2006) and that this deterioration starts rather early—before age 30 (Heffner 2004).…”

Section: Centenarians Compared To Their Shorter-lived Siblings: Thesupporting

confidence: 69%

Determinants of exceptional human longevity: new ideas and findings

Gavrilov¹,

Gavrilova²

2014

Populationyearbook

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Studies of centenarians are useful in identifying factors leading to long life and avoidance of fatal diseases. In this article we consider several approaches to study effects of early-life and midlife conditions on survival to advanced ages: use of non-biological relatives as controls, the within-family analysis, as well as a sampling of controls from the same population universe as centenarians. These approaches are illustrated using data on American centenarians, their relatives and unrelated shorterlived controls obtained from the online genealogies. The within-family analysis revealed that young maternal age at person's birth is associated with higher chances of exceptional longevity. Comparison of centenarians and their shorter-lived peers (died at age 65 and sampled from the same pool of online genealogies) confirmed that birth timing in the second half of the calendar year predicts survival to age 100. Parental longevity as well as some childhood and midlife characteristics also proved to be significant predictors of exceptional longevity.

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Section: Centenarians Compared To Their Shorter-lived Siblings: Thesupporting

confidence: 69%

Determinants of exceptional human longevity: new ideas and findings

Gavrilov¹,

Gavrilova²

2014

Populationyearbook

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“…Experiments on laboratory mice found that the offspring born to younger mothers live longer (Tarin et al, 2005). This study also demonstrated that the largest effect is observed at later life.…”

Section: Resultsmentioning

confidence: 99%

Biodemography of Exceptional Longevity: Early-Life and Mid-Life Predictors of Human Longevity

Gavrilov

Gavrilova

2012

Biodemography and Social Biology

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Effects of early-life and middle-life conditions on exceptional longevity are explored in this study using two matched case-control studies. The first study compares 198 validated centenarians born in the United States in 1890-1893 to their shorter-lived siblings. Family histories of centenarians were reconstructed and exceptional longevity validated using early U.S. censuses, Social Security Administration Death Master File, state death indexes, online genealogies and other supplementary data resources. Siblings born to young mothers (<25 years) had significantly higher chances to live to 100 compared to siblings born to older mothers (odds ratio = 2.03, 95% CI = 1.33 - 3.11, P = 0.001) while paternal age and birth order were not associated with exceptional longevity. The second study explores whether people living to 100 and beyond are any different in physical characteristics at young age from their shorter-lived peers. A random representative sample of 240 men born in 1887 and survived to age 100 was selected from the US Social Security Administration database and linked to the US WWI civil draft registration cards collected in 1917 when these men were 30 years old. These validated centenarians were then compared to randomly selected controls matched by calendar year of birth, race and place of draft registration in 1917. It was found that ‘stout’ body build (being in the heaviest 15% of population) was negatively associated with survival to age 100 years. Farmer occupation and large number of children (4+) at age 30 increased the chances of exceptional longevity. Detailed description of dataset development, data cleaning procedure and validation of exceptional longevity is provided for both studies. These results demonstrate that matched case-control design is a useful approach in exploring effects of early-life conditions and middle-life characteristics on exceptional longevity.

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“…Data analyzed in this study were extracted from a database generated in two previous studies designed to ascertain the long-term effects of maternal [14] and paternal [15] aging on offspring’s reproductive fitness and longevity. All the animal experiments performed in these studies were conducted in accordance with the National Research Council’s publication Guide for the Care and Use of Laboratory Animals [16].…”

Section: Methodsmentioning

confidence: 99%

Absence of long-term effects of reproduction on longevity in the mouse model

Tarı́n

Gómez-Piquer

García-Palomares

et al. 2014

Reprod Biol Endocrinol

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BackgroundMost human demographic data, particularly those on natural fertility populations, find no relationship or even a positive association between fertility and longevity. The present study aims to ascertain whether there is a trade-off between fertility and longevity in the mouse model.MethodsThe study was focused on the first litter produced by 10- to 14-wk-old hybrid (C57BL/6JIco female X CBA/JIco male) mice. A single female/male per litter was individually housed with a male/female at the age of 25 and 52 wk, respectively, until the end of reproductive life in females or natural death in males under controlled housing conditions. Post-reproductive females and virgin mice were reared until natural death. Cox regression models with forward stepwise variable selection were fitted to examine the effect of several fertility variables on expectation of survival times.ResultsVirgin females displayed higher life expectancy than virgin males. The relative risk of dying for a virgin male at a particular age was 2.116 [99% confidence interval: 1.317, 3.398] times that of a virgin female. No significant differences on expectation of survival times between virgin and mated females, and between virgin and mated males were found. Furthermore, total number of pups at weaning and total number of litters produced by a dam/stud, time interval between mating and last litter, time interval between litters, and age at last litter were not significant predictors of expectation of survival times in both mated females and mated males.ConclusionsLike in most human studies, the present study evidences no relationship between total number of offspring/litters produced by a dam/stud and expectation of survival times. Moreover, the present data are in agreement with the general phenomenon of a bias in life expectancy in favor of females.

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Delayed Motherhood Decreases Life Expectancy of Mouse Offspring1

Cited by 45 publications

References 33 publications

Determinants of exceptional human longevity: new ideas and findings

Determinants of exceptional human longevity: new ideas and findings

Biodemography of Exceptional Longevity: Early-Life and Mid-Life Predictors of Human Longevity

Absence of long-term effects of reproduction on longevity in the mouse model

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