Delayed Onset and Protracted Course of Psoriasis-like Secondary Syphilitic Lesions in a HIV-sero­positive Man Who has Sex with Men: A Case Report

Peng, Rui-Rui; Shang, Shuxian; J, Chen; Shi, Mei-ju; Zhou, Pengfei; Long, Fu‐Quan

doi:10.2340/00015555-3302

Cited by 3 publications

(3 citation statements)

References 12 publications

(13 reference statements)

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“…[11][12][13][14][15] In most cases, syphilis was not correctly diagnosed at the beginning and the patients were treated for psoriasis. 11,12,16 To our knowledge, there is not a clear cut explanation of the pathophysiological mechanism of this type of presentation. 3 A familiar history of psoriasis was also not reported by our patient.…”

Section: Discussionmentioning

confidence: 96%

Psoriasiform syphilis: a challenge

et al. 2021

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Syphilis is one of the greatest masqueraders in dermatology, like mycosis fungoides or sarcoidosis. In fact, secondary syphilis can simulate different dermatological conditions, not only clinically but also histopathologically. A 34-year old Brazilian man from Manaus (Amazonas) attended our Department complaining for 2 weeks of asthenia, weight loss and multiple asymptomatic disseminated erythematous papules and scaly plaques with well-defined borders and a tendency to confluence were observed on the trunk, neck and extremities, clinically similar to psoriasis guttata. The skin biopsy and laboratory tests disclosed secondary syphilis and the patient was treated with intramuscular benzathine penicillin with prednisolone, with a complete resolution. Psoriasiform syphilis, which imitates psoriasis, was well known by old dermatologists and was called syphilide psoriasiforme or psoriasis syphilitique. Psoriasiform syphilis is one of the atypical presentations of secondary syphilis and dermatologists should be aware of psoriasiform syphilis in order not to improperly treat syphilis patients with immunosuppressive drugs; also, pathologists should be aware of secondary syphilis histopathological features.

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Section: Discussionmentioning

confidence: 96%

Psoriasiform syphilis: a challenge

et al. 2021

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“…Once a diagnosis of syphilis was made, the medical team questioned if the worsening maculopapular rash represented a psoriasis exacerbation or psoriasiform syphilis. Although rare, there are several case reports describing an atypical cutaneous psoriasiform presentation of syphilis [ 3 - 4 , 7 , 16 ]. These cases typically present with scaly, erythematous plaques on the trunk or the palms and soles, resembling psoriasis.…”

Section: Discussionmentioning

confidence: 99%

“…Syphilis manifestations can be further altered by comorbid conditions, such as HIV or psoriasis. Atypical syphilis cases have been described more frequently in patients with concomitant HIV infection [3][4][5]. Psoriasiform syphilis is an atypical presentation that is important to consider in patients with psoriasis on immunosuppressants.…”

Section: Introductionmentioning

confidence: 99%

An Atypical Presentation of Acute Syphilitic Posterior Placoid Chorioretinitis With Concurrent Psoriasis Vulgaris Flare in an African American Male Infected With HIV

Melton¹,

Thornton²,

Pasagic³

2023

Cureus

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The diagnosis of secondary syphilis can be challenging due to its various clinical and histopathological presentations. A late or incorrect diagnosis can result in disease progression with consequent morbidity or mortality. Due to the importance of a correct diagnosis and specific treatment, it is of the utmost importance for healthcare providers to consider the various manifestations of syphilis. We describe an atypical presentation of secondary syphilis in an African American man infected with HIV and chronic psoriasis, who presented with two months of diffuse maculopapular rash and new visual changes, found to have acute syphilitic placoid chorioretinitis (ASPCC) and a psoriasis vulgaris flare.

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Secondary syphilis presenting as Syphilide psoriasiforme: lessons from the older syphilology literature

Martins

Lima

Eyer-Silva

et al. 2020

Rev. Inst. Med. trop. S. Paulo

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It is essential for health care providers to be familiar with the full spectrum of clinical presentations of syphilis. We present herein a case of syphilide psoriasiforme, an uncommon but well recognized clinical presentation of secondary syphilis. A 46-year-old HIV-infected female patient was referred to our attention with a presumptive diagnosis of palmoplantar psoriasis. On examination, there were exuberant pinkish-red papules and plaques covered with a thick silvery scale in the palms, flexor surfaces of the wrists, and the medial longitudinal arches of the feet. Serological and histopathological analyses uncovered the diagnosis of syphilis. Clinical remission was obtained after treatment. A detailed review of the literature on syphilide psoriasiforme, including descriptions from older syphilology texts is provided. The present case report emphasizes the need for clinicians to have a heightened awareness of the varied and unusual clinical phenotypes of syphilis.

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Delayed Onset and Protracted Course of Psoriasis-like Secondary Syphilitic Lesions in a HIV-seropositive Man Who has Sex with Men: A Case Report

Cited by 3 publications

References 12 publications

Psoriasiform syphilis: a challenge

Psoriasiform syphilis: a challenge

An Atypical Presentation of Acute Syphilitic Posterior Placoid Chorioretinitis With Concurrent Psoriasis Vulgaris Flare in an African American Male Infected With HIV

Secondary syphilis presenting as Syphilide psoriasiforme: lessons from the older syphilology literature

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Delayed Onset and Protracted Course of Psoriasis-like Secondary Syphilitic Lesions in a HIV-sero­positive Man Who has Sex with Men: A Case Report

Cited by 3 publications

References 12 publications

Psoriasiform syphilis: a challenge

Psoriasiform syphilis: a challenge

An Atypical Presentation of Acute Syphilitic Posterior Placoid Chorioretinitis With Concurrent Psoriasis Vulgaris Flare in an African American Male Infected With HIV

Secondary syphilis presenting as Syphilide psoriasiforme: lessons from the older syphilology literature

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Delayed Onset and Protracted Course of Psoriasis-like Secondary Syphilitic Lesions in a HIV-seropositive Man Who has Sex with Men: A Case Report