Deletion of the Tumor Suppressor NFKBIA in Triple-Negative Breast Cancer

Bredel, Markus; Kim, H.; Nanda, Tanya; Scholtens, D; Robe, P.; Branimir, S.I.; Bonner, James A.

doi:10.1016/j.ijrobp.2013.06.254

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mutations have been widely reported to contribute to specific functional alteration of crucial proteins including NFKBIA in diseases especially in various cancer subtypes like pancreatic cancer [ 38 – 41 ]. What is more, as one of the crucial inhibitory components of NF-kappa-B pathway, NFKBIA has been reported to be downregulated in cancer [ 42 , 43 ]. The overexpression of NFKBIA has also been reported to be associated with a better prognosis of various treatment methods in different human tumor subtypes, especially for the prognosis of patients that have taken alpha 1-adrenoceptor antagonists and radiotherapy [ 44 , 45 ].…”

Section: Resultsmentioning

confidence: 99%

Mining for Candidate Genes Related to Pancreatic Cancer Using Protein-Protein Interactions and a Shortest Path Approach

Yuan

Zhang

Wan

et al. 2015

BioMed Research International

View full text Add to dashboard Cite

Pancreatic cancer (PC) is a highly malignant tumor derived from pancreas tissue and is one of the leading causes of death from cancer. Its molecular mechanism has been partially revealed by validating its oncogenes and tumor suppressor genes; however, the available data remain insufficient for medical workers to design effective treatments. Large-scale identification of PC-related genes can promote studies on PC. In this study, we propose a computational method for mining new candidate PC-related genes. A large network was constructed using protein-protein interaction information, and a shortest path approach was applied to mine new candidate genes based on validated PC-related genes. In addition, a permutation test was adopted to further select key candidate genes. Finally, for all discovered candidate genes, the likelihood that the genes are novel PC-related genes is discussed based on their currently known functions.

show abstract

Section: Resultsmentioning

confidence: 99%

Mining for Candidate Genes Related to Pancreatic Cancer Using Protein-Protein Interactions and a Shortest Path Approach

Yuan

Zhang

Wan

et al. 2015

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…NFkB is constitutively activated in ER−negative and TN breast tumors, mediates adaptive resistance to ionizing radiation and chemotherapy, and is required for epithelial–mesenchymal transition (EMT) associated with metastatic progression of BC. NFKBIA deletions, leading to a haploinsufficient effect on NFKBIA expression and thus the transactivation of several NFkB target genes with important roles in TN breast carcinogenesis, are significantly associated with TN patients [35]. hsa-miR-423-5p has been observed to be upregulated in drug-resistant BC cells from the parental MDA-MB-231 cell line [36].…”

Section: Discussionmentioning

confidence: 99%

Integrative Analysis Reveals Subtype-Specific Regulatory Determinants in Triple Negative Breast Cancer

Huang

et al. 2019

Cancers

View full text Add to dashboard Cite

Different breast cancer (BC) subtypes have unique gene expression patterns, but their regulatory mechanisms have yet to be fully elucidated. We hypothesized that the top upregulated (Yin) and downregulated (Yang) genes determine the fate of cancer cells. To reveal the regulatory determinants of these Yin and Yang genes in different BC subtypes, we developed a lasso regression model integrating DNA methylation (DM), copy number variation (CNV) and microRNA (miRNA) expression of 391 BC patients, coupled with miRNA–target interactions and transcription factor (TF) binding sites. A total of 25, 20, 15 and 24 key regulators were identified for luminal A, luminal B, Her2-enriched, and triple negative (TN) subtypes, respectively. Many of the 24 TN regulators were found to regulate the PPARA and FOXM1 pathways. The Yin Yang gene expression mean ratio (YMR) and combined risk score (CRS) signatures built with either the targets of or the TN regulators were associated with the BC patients’ survival. Previously, we identified FOXM1 and PPARA as the top Yin and Yang pathways in TN, respectively. These two pathways and their regulators could be further explored experimentally, which might help to identify potential therapeutic targets for TN.

show abstract

Deletion of the Tumor Suppressor NFKBIA in Triple-Negative Breast Cancer

Cited by 2 publications

References 0 publications

Mining for Candidate Genes Related to Pancreatic Cancer Using Protein-Protein Interactions and a Shortest Path Approach

Mining for Candidate Genes Related to Pancreatic Cancer Using Protein-Protein Interactions and a Shortest Path Approach

Integrative Analysis Reveals Subtype-Specific Regulatory Determinants in Triple Negative Breast Cancer

Contact Info

Product

Resources

About