Delineating penetration enhancer-enriched liquid crystalline nanostructures as novel platforms for improved ophthalmic delivery

Gendy, Mohamed A.M. El; Mansour, Mahmoud A.; El-Assal, Mona I.A.; Ishak, Rania A.H.; Mortada, Nahed D.

doi:10.1016/j.ijpharm.2020.119313

Cited by 17 publications

(7 citation statements)

References 56 publications

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“…The type of lipid used in the preparation plays an important role in tissue distribution. Among the prepared lipid systems, fluorescence analysis showed that the combination of oleic acid, Captex ® 8000 and Capmul ® MCM improved the penetration of the systems into the mucosa by increasing diffusivity due to both surfactant properties and the ability to disrupt the organization of the lipid bilayer [ 106 ]. Once again, Nile Red was used in the work of Kapadia et al in order to visualize drug-loaded emulsomes.…”

Section: Fluorescent Nanosystems In Ocular Applicationmentioning

confidence: 99%

“…Moreover, rapid clearance remains a challenge for nanosystems as they need to release their payload before being eliminated from the eye. Many studies focus on assessing the distribution in various tissues once the formulation has been instilled into the eye [ 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 134 , 137 , 138 , 139 ]. Unfortunately, few studies focus on assessing how mechanisms including blinking, tear drainage and ocular metabolism may interact with nanosystems [ 66 , 115 ].…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

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Fluorescent Nanosystems for Drug Tracking and Theranostics: Recent Applications in the Ocular Field

et al. 2022

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The greatest challenge associated with topical drug delivery for the treatment of diseases affecting the posterior segment of the eye is to overcome the poor bioavailability of the carried molecules. Nanomedicine offers the possibility to overcome obstacles related to physiological mechanisms and ocular barriers by exploiting different ocular routes. Functionalization of nanosystems by fluorescent probes could be a useful strategy to understand the pathway taken by nanocarriers into the ocular globe and to improve the desired targeting accuracy. The application of fluorescence to decorate nanocarrier surfaces or the encapsulation of fluorophore molecules makes the nanosystems a light probe useful in the landscape of diagnostics and theranostics. In this review, a state of the art on ocular routes of administration is reported, with a focus on pathways undertaken after topical application. Numerous studies are reported in the first section, confirming that the use of fluorescent within nanoparticles is already spread for tracking and biodistribution studies. The first section presents fluorescent molecules used for tracking nanosystems’ cellular internalization and permeation of ocular tissues; discussions on the classification of nanosystems according to their nature (lipid-based, polymer-based, metallic-based and protein-based) follows. The following sections are dedicated to diagnostic and theranostic uses, respectively, which represent an innovation in the ocular field obtained by combining dual goals in a single administration system. For its great potential, this application of fluorescent nanoparticles would experience a great development in the near future. Finally, a brief overview is dedicated to the use of fluorescent markers in clinical trials and the market in the ocular field.

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Section: Fluorescent Nanosystems In Ocular Applicationmentioning

confidence: 99%

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Fluorescent Nanosystems for Drug Tracking and Theranostics: Recent Applications in the Ocular Field

et al. 2022

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“…Cubosomes represent the nanostructured systems that result upon the colloidal dispersion of bicontinuous cubic liquid crystalline structures in aqueous media using suitable surfactants [ 148 ]. Cubosomes particle sizes range from 100 to 300 nm and are either formed spontaneously by self-assembly of amphiphilic lipids such as glyceryl monostearate in excess aqueous media or using high pressure emulsification of glycerol monooleate and water using suitable surfactants such as poloxamer 407 as a steric stabilizer of the bulk cubic phase lipid that has the appearance of rigid gels [ 151 , 152 ].…”

Section: Chitosan-based Mucosal Deliverymentioning

confidence: 99%

“…In comparison to the bilayer lamellar structure of liposomes, cubosomes display many distinct features which make them promising candidates for ophthalmic delivery. For example, in addition to being biocompatible, cubosomes are reported to be mucoadhesive [ 151 ]. In addition, their higher structural similarity with biological membranes enhances their fusion with the lipid bilayers of any mucosal epithelia.…”

Section: Chitosan-based Mucosal Deliverymentioning

confidence: 99%

“…Furthermore, they have higher physical stability due to the larger ratio of lipid bilayers used and the presence of strong electrical repulsive forces. They also have higher specific surface area and good flowability at low viscosity while allowing for the incorporation of considerable amounts of hydrophilic, hydrophobic, as well as amphiphilic drugs [ 151 ].…”

Section: Chitosan-based Mucosal Deliverymentioning

confidence: 99%

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Posterior Segment Ophthalmic Drug Delivery: Role of Muco-Adhesion with a Special Focus on Chitosan

et al. 2021

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Posterior segment eye diseases (PSEDs) including age macular degeneration (AMD) and diabetic retinopathy (DR) are amongst the major causes of irreversible blindness worldwide. Due to the numerous barriers encountered, highly invasive intravitreal (IVT) injections represent the primary route to deliver drugs to the posterior eye tissues. Thus, the potential of a more patient friendly topical route has been widely investigated. Mucoadhesive formulations can decrease precorneal clearance while prolonging precorneal residence. Thus, they are expected to enhance the chances of adherence to corneal and conjunctival surfaces and as such, enable increased delivery to the posterior eye segment. Among the mucoadhesive polymers available, chitosan is the most widely explored due to its outstanding mucoadhesive characteristics. In this review, the major PSEDs, their treatments, barriers to topical delivery, and routes of topical drug absorption to the posterior eye are presented. To enable the successful design of mucoadhesive ophthalmic drug delivery systems (DDSs), an overview of mucoadhesion, its theory, characterization, and considerations for ocular mucoadhesion is given. Furthermore, chitosan-based DDs that have been explored to promote topical drug delivery to the posterior eye segment are reviewed. Finally, challenges of successful preclinical to clinical translation of these DDSs for posterior eye drug delivery are discussed.

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Study on the opening effect of eucalyptol on the blood–brain barrier and its brain pharmacokinetics

Dao

Jiang

Chen

et al. 2023

Biomedical Chromatography

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Eucalyptol, a natural epoxide monoterpene, was found in rat brain tissue after oral administration in our previous study, suggesting that the compound may possess the ability to pass the blood–brain barrier (BBB). However, a few studies have demonstrated that eucalyptol does penetrate the BBB. The aims of this study were to determine the opening effect of eucalyptol on the BBB in rats, to establish and validate a method for the determination of eucalyptol in brain tissue, and to reveal its brain pharmacokinetic characteristics. The opening effect of BBB was assessed by dye extravasation and ultrastructural alterations, and the quantitative method of eucalyptol in rat brain tissue was established and confirmed. For pharmacokinetic research, rat brain samples were taken at 0.05, 0.167, 0.5, 1, 2.5, 5, 10, and 15 h after administration. There was a significantly higher extravasation of Evans blue from the brain parenchyma of rats in the medium‐dose eucalyptol group (P < 0.01), which was associated with the BBB's altered ultrastructure. It is suggested that eucalyptol increased the permeability of the BBB. After oral administration, eucalyptol was quickly absorbed by the brain. This study provides valuable information on eucalyptol use to treat illnesses of the central nervous system.

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Delineating penetration enhancer-enriched liquid crystalline nanostructures as novel platforms for improved ophthalmic delivery

Cited by 17 publications

References 56 publications

Fluorescent Nanosystems for Drug Tracking and Theranostics: Recent Applications in the Ocular Field

Fluorescent Nanosystems for Drug Tracking and Theranostics: Recent Applications in the Ocular Field

Posterior Segment Ophthalmic Drug Delivery: Role of Muco-Adhesion with a Special Focus on Chitosan

Study on the opening effect of eucalyptol on the blood–brain barrier and its brain pharmacokinetics

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