Delineation of Gross Tumor Volume (GTV) for Radiation Treatment Planning of Locally Advanced Rectal Cancer Using Information From MRI or FDG-PET/CT: A Prospective Study

Brændengen, Morten; Hansson, Karl; Radu, Calin; Siegbahn, Albert; Jacobsson, Hans; Glimelius, Bengt

doi:10.1016/j.ijrobp.2011.03.031

Cited by 49 publications

(35 citation statements)

References 30 publications

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“…Changes of the GTV shape and size as a consequence of combining MRI-and PET-information were analyzed by Braendengen et al [51], studying the combination of GTV-MRI and GTV-PET in rectal cancer. Target volume definition for fractionated radiotherapy in patients with intracranial meningiomas by correlation of CT, MRI, and [ 68 Ga]-PET has been studied by Milker-Zabel et al [52] and by Thorwarth et al [53].…”

Section: Pet and Mri For Planning In Radiotherapymentioning

confidence: 99%

Review of potential improvements using MRI in the radiotherapy workflow

Torresin

Brambilla

Monti

et al. 2015

Zeitschrift für Medizinische Physik

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Section: Pet and Mri For Planning In Radiotherapymentioning

confidence: 99%

Review of potential improvements using MRI in the radiotherapy workflow

Torresin

Brambilla

Monti

et al. 2015

Zeitschrift für Medizinische Physik

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“…This is also what trials including meta-analyses have shown, at least in patients with intermediate tumours who are the great majority of the patients included in the trials. If the tumour is locally advanced/ugly with overgrowth to non-resectable organs or structures, fortunately rarely seen (62,63), a longer interval may be needed to safely obtain an R0 resection.…”

Section: Surgery Is Delayed More and Morementioning

confidence: 99%

On a prolonged interval between rectal cancer (chemo)radiotherapy and surgery

Glimelius

2017

Upsala Journal of Medical Sciences

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Preoperative radiotherapy (RT) or chemoradiotherapy (CRT) is often required before rectal cancer surgery to obtain low local recurrence rates or, in locally advanced tumours, to radically remove the tumour. RT/CRT in tumours responding completely can allow an organ-preserving strategy. The time from the end of the RT/CRT to surgery or to the decision not to operate has been prolonged during recent years. After a brief review of the literature, the relevance of the time interval to surgery is discussed depending upon the indication for RT/CRT. In intermediate rectal cancers, where the aim is to decrease local recurrence rates without any need for down-sizing/-staging, short-course RT with immediate surgery is appropriate. In elderly patients at risk for surgical complications, surgery could be delayed 5–8 weeks. If CRT is used, surgery should be performed when the acute radiation reaction has subsided or after 5–6 weeks. In locally advanced tumours, where CRT is indicated, the optimal delay is 6–8 weeks. In patients not tolerating CRT, short-course RT with a 6–8-week delay is an alternative. If organ preservation is a goal, a first evaluation should preferably be carried out after about 6 weeks, with planned surgery for week 8 if the response is inadequate. In case the response is good, a new evaluation should be carried out after about 12 weeks, with a decision to start a ‘watch-and-wait’ programme or operate. Chemotherapy in the waiting period is an interesting option, and has been the subject of recent trials with promising results.

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“…The PET/CT GTVs were statistically significantly larger than the CT GTVs, the mean difference being 25%. Brændengen et al [ 41 ] compared delineation of GTV using PET/CT and MRI for a group of patients with rectal cancer. Seventy-seven consecutive patients were prospectively screened for inclusion in the study.…”

Section: Positron Emission Tomographymentioning

confidence: 99%

Clinical application of multimodality imaging in radiotherapy treatment planning for rectal cancer

Wang

Zhe

2013

Cancer Imaging

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Radiotherapy plays an important role in the treatment of rectal cancer. Three-dimensional conformal radiotherapy and intensity-modulated radiotherapy are mainstay techniques of radiotherapy for rectal cancer. However, the success of these techniques is heavily reliant on accurate target delineation and treatment planning. Computed tomography simulation is a cornerstone of rectal cancer radiotherapy, but there are limitations, such as poor soft-tissue contrast between pelvic structures and partial volume effects. Magnetic resonance imaging and positron emission tomography (PET) can overcome these limitations and provide additional information for rectal cancer treatment planning. PET can also reduce the interobserver variation in the definition of rectal tumor volume. However, there is a long way to go before these image modalities are routinely used in the clinical setting. This review summarizes the most promising studies on clinical applications of multimodality imaging in target delineation and treatment planning for rectal cancer radiotherapy.

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Delineation of Gross Tumor Volume (GTV) for Radiation Treatment Planning of Locally Advanced Rectal Cancer Using Information From MRI or FDG-PET/CT: A Prospective Study

Cited by 49 publications

References 30 publications

Review of potential improvements using MRI in the radiotherapy workflow

Review of potential improvements using MRI in the radiotherapy workflow

On a prolonged interval between rectal cancer (chemo)radiotherapy and surgery

Clinical application of multimodality imaging in radiotherapy treatment planning for rectal cancer

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