Delivery Systems and Dosing for Antipsychotics

Rabin, Cara R.; Siegel, Steven J.

doi:10.1007/978-3-642-25761-2_11

Cited by 8 publications

(6 citation statements)

References 115 publications

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“…The driving force for SSD release by diffusion is the SSD concentration gradient between the thermo-responsive cellulose hydrogel and the wound surface [ 85 ]. Besides SSD diffusion, SSD release from thermo-responsive cellulose hydrogels is also contributed by physical dissolution of the thermo-responsive cellulose hydrogel as a result of its degradation [ 86 ]. As a thermo-responsive cellulose hydrogel’s matrix is eroded, entrapped SSD molecules are set free and released to the wound surface.…”

Section: Resultsmentioning

confidence: 99%

Green Synthesis of Thermo-Responsive Hydrogel from Oil Palm Empty Fruit Bunches Cellulose for Sustained Drug Delivery

Al-Rajabi

Teow

2021

Polymers

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Drug delivery is a difficult task in the field of dermal therapeutics, particularly in the treatment of burns, wounds, and skin diseases. Conventional drug delivery mediums have some limitations, including poor retention on skin/wound, inconvenience in administration, and uncontrolled drug release profile. Hydrogels able to absorb large amount of water and give a spontaneous response to stimuli imposed on them are an attractive solution to overcome the limitations of conventional drug delivery media. The objective of this study is to explore a green synthesis method for the development of thermo-responsive cellulose hydrogel using cellulose extracted from oil palm empty fruit bunches (OPEFB). A cold method was employed to prepare thermo-responsive cellulose hydrogels by incorporating OPEFB-extracted cellulose and Pluronic F127 (PF127) polymer. The performance of the synthesized thermo-responsive cellulose hydrogels were evaluated in terms of their swelling ratio, percentage of degradation, and in-vitro silver sulfadiazine (SSD) drug release. H8 thermo-responsive cellulose hydrogel with 20 w/v% PF127 and 3 w/v% OPEFB extracted cellulose content was the best formulation, given its high storage modulus and complex viscosity (81 kPa and 9.6 kPa.s, respectively), high swelling ratio (4.22 ± 0.70), and low degradation rate (31.3 ± 5.9%), in addition to high t50% value of 24 h in SSD in-vitro drug release to accomplish sustained drug release. The exploration of thermo-responsive cellulose hydrogel from OPEFB would promote cost-effective and sustainable drug delivery system with using abundantly available agricultural biomass.

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Section: Resultsmentioning

confidence: 99%

Green Synthesis of Thermo-Responsive Hydrogel from Oil Palm Empty Fruit Bunches Cellulose for Sustained Drug Delivery

Al-Rajabi

Teow

2021

Polymers

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“…This could be attributed to the difference in hydrophobicity of the drugs. Hydrophobic drugs accelerate degradation, but highly hydrophobic drugs (high Log D values) reduce water penetration and polymer degradation [29]. Accelerated degradation of PLGA led to faster release of simvastatin, i.e., milligrams of the drug compared to micrograms from the polymeric prodrugs.…”

Section: Discussionmentioning

confidence: 99%

Biodegradable polymerized simvastatin stimulates bone formation

et al. 2019

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Previous research from our labs demonstrated the synthesis of polymerized simvastatin by ringopening polymerization and slow degradation with controlled release of simvastatin in vitro. The objective of the present study was to evaluate the degradation and intramembranous bone-forming potential of simvastatin-containing polyprodrugs in vivo using a rat calvarial onlay model.Poly(ethylene glycol)-block-poly(simvastatin) and poly(ethylene glycol)-block-poly(simvastatin)ran-poly(glycolide) were compared with simvastatin conventionally encapsulated in poly(lacticco-glycolic acid) (PLGA) and pure PLGA. The rate of degradation was higher for PLGA with and without simvastatin relative to the simvastatin polyprodrugs. Significant new bone growth at the circumference of poly(ethylene glycol)-block-poly(simvastatin) disks was observed beginning at 4 weeks, whereas severe bone resorption (4 weeks) and bone loss (8 weeks) were observed for PLGA loaded with simvastatin. No significant systemic effects were observed for serum total cholesterol and body weight. Increased expression of osteogenic (BMP-2, Runx2, and ALP), angiogenic (VEGF), and inflammatory cytokines (IL-6 and NF-ĸB) genes was seen with all polymers at the end of 8 weeks. Poly(ethylene glycol)-block-poly(simvastatin), with slow degradation and drug release, controlled inflammation, and significant osteogenic effect, is a candidate for use in bone regeneration applications.

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“…This can be explained by the high hydrophobicity of NG PCL before degradation and the tendency of hydrophobic materials to keep the erosion at their surfaces. 34 As seen in Figure 9 the water contact angle of NG films was 20% higher than its G equivalent before degradation.…”

Section: Structural Degradation In Pbsmentioning

confidence: 82%

“…While, defects by collagenase on the NG PCL surface appeared as more numerous and small dimension dimples (9.01 ± 1.2 nm of mean depth and ~ 30–40 nm of radius) (Figure 8(e)). This can be explained by the high hydrophobicity of NG PCL before degradation and the tendency of hydrophobic materials to keep the erosion at their surfaces 34 . As seen in Figure 9 the water contact angle of NG films was 20% higher than its G equivalent before degradation.…”

Section: Medical‐grade Pcl Degradation In the Enzymatic Environmentmentioning

confidence: 91%

Different real‐time degradation scenarios of functionalized poly(ε‐caprolactone) for biomedical applications

Rangel

Nguyễn

Egles

et al. 2021

J of Applied Polymer Sci

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Anterior cruciate ligament (ACL) ruptures are a much-commented injury as it can end the season or even career of professional athletes. However, the recovery of a patient from the general population is no less painful during the long period required by current treatments. Artificial ligaments could improve this healing, yet, orthopedic surgeons are still cautious about permanent ACL implants. Therefore, combining biodegradation and bioactivity could be a key feature for the popularization of these devices. This study aim at evaluating the real-time degradation of poly(ε-caprolactone) (PCL) grafted with the bioactive polymer sodium polystyrene sulfonate in different scenarios. PCL physical-chemical properties were evaluated before and after degradation. In addition, in vitro experiments were realized to confirm the long term influence of the grafting on cell response. Altogether, we were able to show different degradations scenarios, enabling to study the impact of degradation environment on degradation mode and rate of functionalized PCL.

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Delivery Systems and Dosing for Antipsychotics

Cited by 8 publications

References 115 publications

Green Synthesis of Thermo-Responsive Hydrogel from Oil Palm Empty Fruit Bunches Cellulose for Sustained Drug Delivery

Green Synthesis of Thermo-Responsive Hydrogel from Oil Palm Empty Fruit Bunches Cellulose for Sustained Drug Delivery

Biodegradable polymerized simvastatin stimulates bone formation

Different real‐time degradation scenarios of functionalized poly(ε‐caprolactone) for biomedical applications

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