Dendrimer encapsulation enhances anti-inflammatory efficacy of silver nanoparticles

Liu, Xuelai; Hao, Wei; Lok, Chun‐Nam; Wang, Yue Chun; Zhang, Ruizhong; Wong, Kenneth K.

doi:10.1016/j.jpedsurg.2014.09.033

Cited by 43 publications

(15 citation statements)

References 40 publications

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“…It has been suggested that AgNPs may block the respiratory chain, as well as damage the DNA and cell wall of bacteria, leading to the death of bacteria 30,33 . Apart from its anti-microbial activity, the anti-inflammatory activity of AgNPs has also been demonstrated in skin wound [34][35][36][37] , intestine and bladder 38,39 . AgNPs suppress the production of the early pro-inflammatory cytokines, such as IL-6, but promote the production of an anti-inflammatory cytokine IL-10 at the skin wound in the early phase after injury 34 , which would indicate that AgNPs suppress early inflammation.…”

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confidence: 99%

Delayed application of silver nanoparticles reveals the role of early inflammation in burn wound healing

Zhang

Lui

Chen

et al. 2020

Sci Rep

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Burn injury is common, and antimicrobial agents are often applied immediately to prevent wound infection and excessive inflammatory response. Although inflammation is essential for clearing bacteria and creating an environment conducive to the healing process, it is unclear what time-frame inflammation should be present for optimal wound healing. This study critically investigated the role of early inflammation in burn wound healing, and also revealed the molecular mechanisms underlying the pro-healing effects of silver nanoparticles (AgNPs). We created a burn injury mouse model using wild-type and Smad3−/− mice, which were topically treated with AgNPs at different post-burn days, and examined the healing processes of the various groups. We also delineated the molecular pathways underlying the anti-inflammation and pro-healing effects of AgNPs by morphological and histological analysis, immuno-histochemistry, and western blotting. Our results showed that (1) AgNPs regulated pro-inflammatory cytokine IL-6 production of keratinocytes and neutrophils infiltration through KGF-2/p38 signaling pathway, (2) Topical AgNPs treatment immediately after burn injury significantly supressed early inflammation but resulted in delayed healing, (3) A short delay in AgNPs application (post-burn day 3 in our model) allowed early inflammation in a controlled manner, and led to optimal burn wound healing. Thus, our current study showed that some degree of early inflammation was beneficial, but prolonged inflammation was detrimental for burn wound healing. Further evaluation and clinical translation of this finding is warranted.

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confidence: 99%

Delayed application of silver nanoparticles reveals the role of early inflammation in burn wound healing

Zhang

Lui

Chen

et al. 2020

Sci Rep

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“…nadifloxacin and prolifloxacin), which increases their bioavailability and enhances their antibacterial properties [181]. In another approach, silver-dendrimeric NSs were found to have synergistic effects in terms of anti-inflammatory and antimicrobial activity; dendrimers were shown to be an ideal carrier to diminish inflammation, while disinfecting the wound and stimulate healing [182].…”

Section: Nanotechnology For Treatment Of Burn Infections and Woundmentioning

confidence: 99%

Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing

Jahromi

Zangabad

Basri

et al. 2018

Advanced Drug Delivery Reviews

408

189

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According to the latest report from the World Health Organization, an estimated 265,000 deaths still occur every year as a direct result of burn injuries. A widespread range of these deaths induced by burn wound happens in low- and middle-income countries, where survivors face a lifetime of morbidity. Most of the deaths occur due to infections when a high percentage of the external regions of the body area is affected. Microbial nutrient availability, skin barrier disruption, and vascular supply destruction in burn injuries as well as systemic immunosuppression are important parameters that cause burns to be susceptible to infections. Topical antimicrobials and dressings are generally employed to inhibit burn infections followed by a burn wound therapy, because systemic antibiotics have problems in reaching the infected site, coupled with increasing microbial drug resistance. Nanotechnology has provided a range of molecular designed nanostructures (NS) that can be used in both therapeutic and diagnostic applications in burns. These NSs can be divided into organic and non-organic (such as polymeric nanoparticles (NPs) and silver NPs, respectively), and many have been designed to display multifunctional activity. The present review covers the physiology of skin, burn classification, burn wound pathogenesis, animal models of burn wound infection, and various topical therapeutic approaches designed to combat infection and stimulate healing. These include biological based approaches (e.g. immune-based antimicrobial molecules, therapeutic microorganisms, antimicrobial agents, etc.), antimicrobial photo- and ultrasound-therapy, as well as nanotechnology-based wound healing approaches as a revolutionizing area. Thus, we focus on organic and non-organic NSs designed to deliver growth factors to burned skin, and scaffolds, dressings, etc. for exogenous stem cells to aid skin regeneration. Eventually, recent breakthroughs and technologies with substantial potentials in tissue regeneration and skin wound therapy (that are as the basis of burn wound therapies) are briefly taken into consideration including 3D-printing, cell-imprinted substrates, nano-architectured surfaces, and novel gene-editing tools such as CRISPR-Cas.

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“…A similar study investigating dendrimers, as well as AgNPs, showed that both these NPs had antiinflammatory properties. When combined in the form of dendrimer-AgNP composites the anti-inflammatory properties were further augmented, resulting in faster wound healing in vivo (2). Others (121) describe that nanocrystalline Ag dressing decreases adversely high levels of matrix metalloproteinases (MMP) -9, a proteolytic enzyme involved in wound healing.…”

Section: Nanoparticles and Immunomodulationmentioning

confidence: 99%

“…Nanoparticles can be incorporated into biomaterials and scaffolds to create nanocomposite smart materials (Figure 1), which can aid wound healing through their antimicrobial (1), selective anti-and proinflammatory (2), and pro-angiogenic properties (3). They can be used as gene delivery vectors altering intracellular gene expression and protein synthesis related to the wound healing process (4).…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles in wound healing from hope to promise from promise to routine

Seifalian¹

2018

Front Biosci

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Chronic non-healing wounds represent a growing problem due to their high morbidity and cost. Despite recent advances in wound healing, several systemic and local factors can disrupt the weighed physiologic healing process. This paper critically reviews and discusses the role of nanotechnology in promoting the wound healing process. Nanotechnology-based materials have physicochemical, optical and biological properties unique from their bulk equivalent. These nanoparticles can be incorporated into scaffolds to create nanocomposite smart materials, which promote wound healing through their antimicrobial, as well as selective anti- and pro-inflammatory, and pro-angiogenic properties. Owed to their high surface area, nanoparticles have also been used for drug delivery as well as gene delivery vectors. In addition, nanoparticles affect wound healing by influencing collagen deposition and realignment and provide approaches for skin regeneration and wound healing.

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Dendrimer encapsulation enhances anti-inflammatory efficacy of silver nanoparticles

Cited by 43 publications

References 40 publications

Delayed application of silver nanoparticles reveals the role of early inflammation in burn wound healing

Delayed application of silver nanoparticles reveals the role of early inflammation in burn wound healing

Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing

Nanoparticles in wound healing from hope to promise from promise to routine

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