Dendritic development in neocortex of infants with early postnatal life undernutrition

Cordero, María Elena; D'Acuña, Eduardo García; Benveniste, Samuel; Prado, R; Núñez, Juan Antonio Vargas; Colombo, Marta

doi:10.1016/0887-8994(93)90025-8

Cited by 47 publications

(25 citation statements)

References 16 publications

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“…Qualitatively, the stained pyramidal cells in the present study generally resembled those described in the human developmental literature [Marín-Padilla, 1970, 1992Takashima et al, 1980;Mrzljak et al, 1988Mrzljak et al, , 1990Cordero et al, 1993]. Sampled pyramidal neurons exhibited relatively complete arrays of primary basilar dendrites, with rudimentary distal segments in place.…”

Section: Regional Differences In Neonatal Cortexsupporting

confidence: 64%

Regional Dendritic Variation in Neonatal Human Cortex: A Quantitative Golgi Study

Travis

Ford

Jacobs³

2005

Dev Neurosci

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The present study quantitatively compared the basilar dendritic/spine systems of lamina V pyramidal neurons across four hierarchically arranged regions of neonatal human neocortex. Tissue blocks were removed from four Brodmann’s areas (BAs) in the left hemisphere of four neurologically normal neonates (mean age = 41 ± 40 days): primary (BA4 and BA3-1-2), unimodal (BA18), and supramodal cortices (BA10). Tissue was stained with a modified rapid Golgi technique. Ten cells per region (N = 160) were quantified. Despite the small sample size, significant differences in dendritic/spine extent obtained across cortical regions. Most apparent were substantial differences between BA4 and BA10: total dendritic length was 52% greater in BA4 than BA10, and dendritic spine number was 67% greater in BA4 than BA10. Neonatal patterns were compared to adult patterns, revealing that the relative regional pattern of dendritic complexity in the neonate was roughly the inverse of that established in the adult, with BA10 rather than BA4 being the most complex area in the adult. Overall, regional dendritic patterns suggest that the developmental time course of basilar dendritic systems is heterochronous and is more protracted for supramodal BA10 than for primary or unimodal regions (BA4, BA3-1-2, BA18).

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Section: Regional Differences In Neonatal Cortexsupporting

confidence: 64%

Regional Dendritic Variation in Neonatal Human Cortex: A Quantitative Golgi Study

Travis

Ford

Jacobs³

2005

Dev Neurosci

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“…Undernutrition remains the most important nutritional problem in developing countries, and at an early age affects the growth and development of children, especially in conditions of poverty, and has been associated with retarded brain growth and functional development that persists into adult life, such as in our present study (Stoch & Smythe 1963, 1967Winick & Rosso, 1969a,b;Winick, 1975;Stoch et al 1982;Hack & Breslau, 1986;Hack et al 1991;Udani, 1992;Cordero et al 1993;Grantham-McGregor, 1995;Levitsky & Strupp 1995;Brown & Pollitt, 1996;Food and Agriculture Organization, 1996;Ivanovic, 1996;United Nations International Children's Emergency Fund, 1998;Ivanovic et al 2000b;Leiva et al 2001). However, these inter-relationships do not have a direct cause -effect relationship since complex interactions are established during the lifetime of the individuals.…”

Section: Discussionmentioning

confidence: 82%

Nutritional status, brain development and scholastic achievement of Chilean high-school graduates from high and low intellectual quotient and socio-economic status

et al. 2002

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The objective of the present study was to investigate the inter-relationships between nutritional status (past and current nutrition), brain development, and scholastic achievement (SA) of Chilean high-school graduates from high and low intellectual quotient (IQ) and socio-economic status (SES) (mean age 18 : 0 (SD 0 : 9) years). Results showed that independently of SES, highschool graduates with similar IQ have similar nutritional, brain development and SA variables. Multiple regression analysis between child IQ (dependent variable) and age, sex, SES, brain volume (BV), undernutrition during the first year of life, paternal and maternal IQ (independent variables) revealed that maternal IQ (P,0 : 0001), BV (P,0 : 0387) and severe undernutrition during the first year of life (P,0 : 0486), were the independent variables with the greatest explanatory power for child IQ variance (r 2 0 : 707), without interaction with age, sex or SES. Child IQ (P,0 : 0001) was the only independent variable that explained both SA variance (r 2 0 : 848) and academic aptitude test variance (r 2 0 : 876) without interaction with age, sex or SES. These results confirm the hypotheses formulated for this study that: (1) independently of SES, high-school graduates with similar IQ have similar variables of nutritional status, brain development and SA; (2) past nutritional status, brain development, child IQ and SA are strongly and significantly inter-related. These findings are relevant in explaining the complex interactions between variables that affect IQ and SA and can be useful for nutritional and educational planning.

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“…The data reviewed above suggest that either reductions in dendritic branch complexity or length or changes in dendritic spines are consistent features in genetic MR. More limited information is available about non-genetic causes of MR; nevertheless, a few studies demonstrate cytoarchitectonic and dendritic abnormalities similar to those in genetic disorders [reviewed by DeLong (DeLong, 1993)]. Two investigations have shown reduction in dendritic arborizations (Cordero et al, 1993;Benitez-Bribiesca et al, 1999) and spine dysgenesis (Benitez-Bribiesca et al, 1999), in moderate to severe protein-calorie malnutrition. Iodine deficiency leads to MR, deaf-mutism and muscle hypertonia, in addition to the somatic changes associated with cretinism (DeLong, 1993).…”

Section: Dendritic Abnormalities and Cognitive Profilementioning

confidence: 99%

Dendritic Anomalies in Disorders Associated with Mental Retardation

2000

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Dendritic abnormalities are the most consistent anatomical correlates of mental retardation (MR). Earliest descriptions included dendritic spine dysgenesis, which was first associated with unclassified MR, but can also be found in genetic syndromes associated with MR. Genetic disorders with well-defined dendritic anomalies involving branches and/or spines include Down, Rett and fragile-X syndromes. Cytoarchitectonic analyses also suggest dendritic pathology in Williams and Rubinstein-Taybi syndromes. Dendritic abnormalities appear to have syndrome-specific pathogenesis and evolution, which correlate to some extent with their cognitive profile. The significance of dendritic pathology in synaptic circuitry and the role of animal models in the study of MR-associated dendritic abnormalities are also discussed. Finally, a model of genotype to neurologic phenotype pathway in MR, centered in dendritic abnormalities, is postulated.

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Dendritic development in neocortex of infants with early postnatal life undernutrition

Cited by 47 publications

References 16 publications

Regional Dendritic Variation in Neonatal Human Cortex: A Quantitative Golgi Study

Regional Dendritic Variation in Neonatal Human Cortex: A Quantitative Golgi Study

Nutritional status, brain development and scholastic achievement of Chilean high-school graduates from high and low intellectual quotient and socio-economic status

Dendritic Anomalies in Disorders Associated with Mental Retardation

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