Dengue fever and dengue virus in the People's Republic of China

Abstract

Infection with dengue virus (DENV) leads to symptoms variable from dengue fever to severe dengue, which has posed a huge socioeconomic and disease burden to the world population, particularly in tropical and subtropical regions. To date, four serotypes of DENV (DENV-1 to DENV-4) have been identified to sustain the transmission cycle in humans. In the past decades, dengue incidences have become more frequent, and four serotypes and various genotypes have been identified in PR China. Several large-scale dengue outbreaks and frequent local endemics occurred in the southern and coastal provinces, and the imported dengue cases accounted primarily for the initiation of the epidemics. No antiviral drug exists for dengue, and no vaccine has been approved to use in PR China, however strategies including public awareness, national reporting system of infectious diseases and public health emergencies, vector mosquito control, personal protection, and improved environmental sanitation have greatly reduced dengue prevalence. Some new technologies in vector mosquito control are emerging and being applied for dengue control.China's territory spans tropical, subtropical, and temperate climates, hence understanding the dengue status in China will be of beneficial for the global prevention and control of dengue. Here, we review the dengue status in PR China for the past decades and the strategies emerging for dengue control.

A Serotype-Specific and Multiplex PCR Method for Whole-Genome Sequencing of Dengue Virus Directly from Clinical Samples

“…DENVs are known for their genetic diversity within serotype groups and geographical regions ( 1 , 16 ). Currently, consolidation and urban circulation of DENV are rare in mainland China ( 17 , 39 – 43 ). Due to the abundance of rainfall in summer and the wide distribution of Aedes albopictus , DENV outbreaks in mainland China are usually caused by imported strains.…”

The underlying mechanism of Guillain-Barré syndrome in a young patient suffered from Japanese encephalitis virus infection: a case report

“…Liaoning province is located in northeast of China, where neither Zika nor Dengue virus [ 8 , 9 ] are endemic. Although Liaoning province had a low prevalence of JE [ 10 ], there was an outbreak of 69 cases with a 30.4% fatality rate in the summer of 2018, which was very similar to the prevalence of JEV infection in the north of Ningxia in 2018 [ 11 ].…”

Epidemiology of Indigenous Dengue Cases in Zhejiang Province, Southeast China

“…In mainland China, A. albopictus has been found throughout tropical, subtropical, and temperate zones, spanning most of the area from Hainan Province to Liaoning Province, and is the dominant mosquito species in residential areas. A. aegypti is found only in the coastal areas of China, within 22° north latitude, and is confined mainly to Hainan Province ( 10 ). The first licensed dengue vaccine, CYD-TDV (Dengvaxia ® ), has been used in several countries.…”