Dental development in children born to Zikv-infected mothers: a case-based study

Silva, Mabel Cristina Paiva Machado da; Arnaud, Manuela; Lyra, Maria Carlla Aroucha; Filho, Arnoldo Vasconcelos de Alencar; Rocha, Maria Ângela Wanderley; Ramos, Regina Coeli Ferreira; Linden, Vanessa van der; Júnior, Arnaldo de França Caldas; Heimer, Mônica Vilela; Rosenblatt, Aronita

doi:10.1016/j.archoralbio.2019.104598

Cited by 15 publications

(41 citation statements)

References 33 publications

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“…The two other congenital developmental disorders most prevalent in the study were rash hematomas and geographical tongue, both with a frequency of 2.74%. The rash hematoma considered a change of high prevalence in this age group in children with exposure to ZIKV by Silva et al, 5 (53.84%), was rare in the study by Almeida et al, 35 (0.9%) and did not occur in this study.…”

Section: Discussioncontrasting

confidence: 45%

“…However, studies focusing on this issue are still scarce in the literature. [4][5][6][7][8] As a result, the possibilities of interation with the literature are limited, making it often necessary to discuss the results from data observed in child. 23 Thus, unlike studies that analyzed a similar age range in the general population, [24][25][26][27] the occurrence of dental caries was not observed in this study.…”

Section: Discussionmentioning

confidence: 99%

“…2 Some clinical findings in children with microcephaly associated with ZIKV have already been published, such as brain changes, neurological abnormalities, 3 bone and craniofacial deformities. [4][5][6][7][8] Changes have also been reported in children with microcephaly caused by other causes, for example, impaired vision and hearing, delayed cognitive, motor and speech development 8,9 and epilepsy. 10 However, there are few studies describing the types and severity of oral changes in children with microcephaly associated with ZIKV.…”

Section: Introductionmentioning

confidence: 98%

“…There are reports of the occurrence of tooth eruption delay and changes in the eruption sequence 6,8 lip hypotonia, absence of lip sealing and mouth breathing 3 and enamel opacity. 5,8 Carvalho et al, 11 described that, in a population of 30 children with this condition, 20% had inadequate tongue position at rest and also registered the presence of short labial or lingual curb, micrognathia, changes in the shape or number of teeth and spasms muscle.In addition to bone development, systemic, local or hereditary disorders that occur during enamel development can cause anomalies in its structure, affecting deciduous and / or permanent dentition [12][13][14] and these dental enamel development defects (DDE) predispose to a greater risk of dental caries. 15,16 According toLunardelli& Peres 17 the extent of the defect will depend on factors such as intensity and duration of the etiologic agent and period of crown formation.…”

Section: Introductionmentioning

confidence: 99%

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Developmental enamel defects and other oral problems in children with microcephaly associate with fetal exposure to zika virus (ZIKV)

Agostino¹,

Chagas²,

Almeida³

et al. 2020

IPCB

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Introduction: Children with microcephaly as a result of fetal exposure to the Zika virus (ZIKV) may experience brain changes, neurological abnormalities, bone and craniofacial deformities. Objective: The objective of this study was to describe oral problems and oral health habits involving children in early childhood with microcephaly associated with fetal exposure to ZIKV. Methodology: A cross-sectional study was carried out on a sample of children with microcephaly, exposed to ZIKV during the pregnancy, attended at the Neuropediatrics outpatient clinic of a reference center in Salvador-BA. Clinical examination of oral conditions and interviews with mothers/ guardians were performed to obtain sociodemographic data and lifestyle habits. A descriptive analysis of the variables and exploratory analysis of factors associated with defects in enamel development (DDE) were done using Pearson's chi square and a significance level of 5%. Results: 74 children participated in the study and a higher frequency of the following oral conditions was observed: delayed eruption chronology (100%), dental biofilm (55.88%) and enamel defects (DDE) (22.06%). Bohn nodules (6.85%), micro dents (2.70%) and ectopically positioned dental elements (1.35%) were less frequent. Only one of them showed incipient caries lesion (1.47%). The occurrence of DDE was more frequent among those with ogival palate, normal weight at birth and who did not have an eruptive delay (p <0.05). In oral habits, 52.70% used a pacifier, 50% feeding at night, 66.22% used sugar and 52.24% brushed teeth before bed. Conclusion: Monitoring oral health conditions is necessary to minimize oral health problems in these children.

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Section: Discussioncontrasting

confidence: 45%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Developmental enamel defects and other oral problems in children with microcephaly associate with fetal exposure to zika virus (ZIKV)

Agostino¹,

Chagas²,

Almeida³

et al. 2020

IPCB

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“…Dental anomalies reflect specific disturbances of one or more stages of odontogenesis, roughly classified as tooth initiation, morphogenesis, cytodifferentiation, mineralization, and bone modeling occurring with eruption [7]. During these processes, viral infections can interrupt dental formation or morphogenesis as do well-known viruses, such as varicella-zoster, parvovirus B-19, herpes infections, rubella, cytomegalovirus and Zika virus [8]. Considering Zika virus as an example, dental shape, chronology and sequence of eruption are evidently altered [9].…”

Section: Dental Anomalies?mentioning

confidence: 99%

COVID-19 Pandemic: Oral Repercussions and its Possible Impact on Oral Health

Maciel

Martelli

et al. 2020

Pesqui. Bras. Odontopediatria Clín. Integr.

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Many viral infections cause oral manifestations, including disorders in odontogenesis, resulting in dental malformations. In this review, based on current knowledge, we will discuss the likely dental and oral consequences of COVID-19. In this article, we review currently available data associated with vertical transmission of COVID-19 and odontogenesis, oral manifestations, and the impact of COVID-19 pandemic on a diagnosis of oral diseases. Owing to the severity of the pandemic, the population's anxiety and fear of becoming infected with COVID-19 may underestimate the signs and symptoms of serious illnesses, besides discourage patients from seeking health, medical or dental services to determine the diagnosis of oral lesions. Thus, the COVID-19 pandemic could be an additional and aggravating factor for the delay of serious illness diagnosis, such as oral squamous cell carcinoma resulting in higher morbidity and worse prognosis. Several changes and oral lesions have been described as oral manifestations of COVID-19, such as dysgeusia, oral ulcers, petechiae, reddish macules, desquamative gingivitis, among others. Besides, it can cause major systemic changes and predispose opportunistic infections. As with other viral infections, oral manifestations, including dental anomalies, can occur as a direct result of SARS-CoV-2 infection. However, further studies are needed to guide and clarify possible oral changes.

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Craniofacial and dental features in children aged 3–5 years with congenital Zika syndrome

et al. 2023

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Objective Zika virus infection has been associated to congenital zika syndrome (CZS) in newborns and is characterized by microcephaly, central/axial motor and sensory dysfunction, dysphagia among other previously described severe health complications. CZS is usually diagnosed postpartum by evident/apparent neural development problems. Although there are some reports of craniofacial/dentition development in CZS, several clinical oral aspects are still unknown. This study describes some structural and functional characteristics of facial and cranial growth and deciduous dentition in CZS-affected children. Material and methods Some cranial, facial and dental characteristics were determined in 14 children with CZS aged 3–5 years and compared them against 12 apparently healthy children paired by age and gender. Results Fourteen CZS cases presented microcephaly, maxillary prognathism, altered facial thirds, asymmetric pupillary line, bruxism (p = 0.006), deep and anterior open bite and distal step decidual molar relationship (p = 0.031). CZS children cannot feed by themselves and most cannot walk and have not develop coordinated and intelligible language according to their chronological age. In contrast, controls presented normal skull features, have autonomous locomotion skills, speak intelligible language, feed by themselves, presented a harmonic intermaxillary relationship and have symmetrical facial thirds. Conclusion Microcephaly, dysphagia, bruxism, mandibular retrognathia, altered facial proportions and malocclusion are the main craniofacial and oral features at CZS. Clinical relevance The complications of CZS including those related with the face and the oral cavity are still being identified. This study revealed some cranial, facial and oral features in children affected by CSZ. Interdisciplinary rehabilitation protocols must address these syndromic features that could improve children and parents living conditions.

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Dental development in children born to Zikv-infected mothers: a case-based study

Cited by 15 publications

References 33 publications

Developmental enamel defects and other oral problems in children with microcephaly associate with fetal exposure to zika virus (ZIKV)

Developmental enamel defects and other oral problems in children with microcephaly associate with fetal exposure to zika virus (ZIKV)

COVID-19 Pandemic: Oral Repercussions and its Possible Impact on Oral Health

Craniofacial and dental features in children aged 3–5 years with congenital Zika syndrome

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