Dental Diseases and Intestinal Dysbiosis Among Children

Shishniashvili, T; Suladze, Tamar; Makhviladze, Manana; Kalandaze, M; Margvelashvili, Vladimer

doi:10.17796/1053-4628-42.3.9

Cited by 6 publications

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“…Regardless of periodontal status, we found that a large number of intestinal microorganisms correlate with periodontal inflammation and destruction (Baeta et al, 2018). Shishniashvili and colleagues determined that the GM facilitates demineralization of dental hard tissue, thereby enabling the formation of caries (Shishniashvili et al, 2018).…”

Section: Introductionmentioning

confidence: 75%

Characterization of the oral microbiome and gut microbiome of dental caries and extrinsic black stain in preschool children

et al. 2023

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IntroductionA lower prevalence of dental caries (hereafter termed “caries”) has been observed in children with dental extrinsic black stain (EBS).MethodsWe investigated the epidemiologic characterization of EBS and explored the possible role of the oral microbiome (OM) and gut microbiome (GM) in EBS formation and caries prevention. In an epidemiologic survey, 2,675 children aged 3–6 years were included. Thirty-eight of these children (7 children had both caries and EBS, 10 had EBS only, 11 had caries only, and 10 were healthy children) were recruited for 16S rRNA sequencing and collection of samples of supragingival plaque and feces. Collected plaque samples were divided into four groups: BCP (EBS+, caries+), BP (EBS+, caries−), CP (EBS−, caries+), and P (EBS−, caries−). Fecal samples were also divided into four groups: BCF (EBS+, caries+), BF (EBS+, caries−), CF (EBS−, caries+), and F (EBS−, caries−).ResultsEBS was observed in 12.10% of this population. Children with EBS had a significantly reduced prevalence of caries and a lower mean value of decayed–missing–filled teeth (dmft; p < 0.01). According to analyses of dental plaque, the P group had the most complex microbiome. The BCP group exhibited greater operational taxonomic unit (OTU) richness but a reduced evenness compared with the BP group, and the CP group showed greater OTU richness than the BP group. At the genus level, higher abundance of Actinomyces and Cardiobacterium species was observed in the BCP group. Higher abundance of Lautropia and Pesudopropionibacteriumin species was observed in the BP group compared with P and CP groups, respectively (p < 0.05). Veillonella species were significantly more common in P and CP groups than in BP groups, whereas Porphyromonas and Fusobacterium species were more common in the CP group (p < 0.05). With regard to the GM, the CF group exhibited greater OTU diversity than the BF group. The GM in the BCF group exhibited the most complex relationships across all fecal groups. GM groups could be distinguished by various unique biomarkers, such as Escherichia and Shigella species in the BCF group, Agathobacter and Ruminococcus species in the CF group, Lactobacillus species in the BF group, and Roseburia species in the F group. Our results suggest that EBS is a possible protective factor against early-childhood caries. Dental plaque and the GM may be relevant to EBS in primary dentition.

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Section: Introductionmentioning

confidence: 75%

Characterization of the oral microbiome and gut microbiome of dental caries and extrinsic black stain in preschool children

et al. 2023

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“…This happens so that the topical fluoride intervenes in the entire bacterial metabolism. Dentists must develop the best remineralizing procedure to consolidate the solidity of external hard tissues consisting of dentin and enamel in cases of intestinal dysbiosis treatment [ 115 ]. The present study ( Table 4 ) [ 115 ] has highlighted how gastrointestinal dysbiosis has a specific influence on the mineralization of mineralized surfaces of the tooth, for which the worsening of dysbiosis determines the level of dental diseases [ 115 ].…”

Section: Discussionmentioning

confidence: 99%

“…Dentists must develop the best remineralizing procedure to consolidate the solidity of external hard tissues consisting of dentin and enamel in cases of intestinal dysbiosis treatment [115]. The present study (Table 4) [115] has highlighted how gastrointestinal dysbiosis has a specific influence on the mineralization of mineralized surfaces of the tooth, for which the worsening of dysbiosis determines the level of dental diseases [115]. Since next-generation sequencing methods became accessible, the microbe's oral groups have been extensively explored, including organisms that are difficult to cultivate [121,122].…”

Section: Microbiota and Dental Demineralizationmentioning

confidence: 99%

Oralbiotica/Oralbiotics: The Impact of Oral Microbiota on Dental Health and Demineralization: A Systematic Review of the Literature

et al. 2022

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The oral microbiota plays a vital role in the human microbiome and oral health. Imbalances between microbes and their hosts can lead to oral and systemic disorders such as diabetes or cardiovascular disease. The purpose of this review is to investigate the literature evidence of oral microbiota dysbiosis on oral health and discuss current knowledge and emerging mechanisms governing oral polymicrobial synergy and dysbiosis; both have enhanced our understanding of pathogenic mechanisms and aided the design of innovative therapeutic approaches as ORALBIOTICA for oral diseases such as demineralization. PubMed, Web of Science, Google Scholar, Scopus, Cochrane Library, EMBEDDED, Dentistry & Oral Sciences Source via EBSCO, APA PsycINFO, APA PsyArticles, and DRUGS@FDA were searched for publications that matched our topic from January 2017 to 22 April 2022, with an English language constraint using the following Boolean keywords: (“microbio*” and “demineralization*”) AND (“oral microbiota” and “demineralization”). Twenty-two studies were included for qualitative analysis. As seen by the studies included in this review, the balance of the microbiota is unstable and influenced by oral hygiene, the presence of orthodontic devices in the oral cavity and poor eating habits that can modify its composition and behavior in both positive and negative ways, increasing the development of demineralization, caries processes, and periodontal disease. Under conditions of dysbiosis, favored by an acidic environment, the reproduction of specific bacterial strains increases, favoring cariogenic ones such as Bifidobacterium dentium, Bifidobacterium longum, and S. mutans, than S. salivarius and A. viscosus, and increasing of Firmicutes strains to the disadvantage of Bacteroidetes. Microbial balance can be restored by using probiotics and prebiotics to manage and treat oral diseases, as evidenced by mouthwashes or dietary modifications that can influence microbiota balance and prevent or slow disease progression.

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“…Mikrobiyota, yaşamın ilk 3 yılı içinde nispeten kararlı, yetişkin benzeri bir biçime ulaşmaktadır ancak diyet, çocukluk ve sonraki yaşamda mikrobiyota içeriği üzerinde önemli bir etkiye sahip olmaya devam etmektedir (8). (10). Yapılan son araştırmalarda oral mikrobiyotadaki değişikliklerin sistemik hastalıklarla bağlantılı olabileceği kaydedilmiştir.…”

Section: Introductionunclassified

Evaluation of the Effects of Gut Flora on General Health and Oral Health

GÜZEL YILDIRIM,

AÇAR,

KASIMOĞLU

2023

Sağlık Bilimlerinde Değer

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Bağırsak mikrobiyotası olarak da bilinen bağırsak florası; bakteri ve virüslerden, arkeler, protozoalar ve mantarlara kadar geniş bir yelpazede mikroorganizmaya ev sahipliği yapmaktadır. İnsan vücudunda 100 trilyondan fazla simbiyotik mikroorganizma ağız boşluğu, deri ve gastrointestinal sistemde kolonileşmektedir. Mikrobiyotanın %70'inden fazlası konak ile simbiyotik bir ilişki içinde gastrointestinal kanalda yaşamaktadır. Ağız boşluğu, insan vücuduna açılan birincil kapıdır ve 770'ten fazla bakteri türünü barındıran, bağırsaktan sonraki en büyük ve çeşitli mikrobiyotaya sahip vücut bölümüdür. İnsan bağırsağı mikrobiyotası; bağışıklık sisteminin gelişmesi, besin sindirimi, patojen mikroorganizmaların kolonizasyonuna karşı savunma ve nörodavranışsal işlevi etkileme dahil olmak üzere konak gelişimine ve konağın fizyolojik fonksiyonlarını sürdürmesine katkıda bulunmaktadır. Yaşamın erken dönemlerindeki mikrobiyota ve konak arasındaki etkileşimler ilerleyen dönemde sağlığı etkileyecek fizyolojik değişikliklerden sorumludur. Bağırsağın ve ağızdaki mikrobiyal toplulukların disbiyozisi otizm, astım, obezite, inflamatuar bağırsak hastalıkları gibi birçok otoimmün ve enflamatuar hastalık ile ilişkilidir ve immün sistemi, bilişsel fonksiyonları ve metabolizmayı etkileyebilmektedir. Mikrobiyotanın önemi göz önünde bulundurularak fekal ve oral mikrobiyota transplantasyonu bir tedavi seçeneği olarak değerlendirilmiştir. Bu derleme, ağız ve bağırsak florasının oluşumunu, oral mikrobiyota ve bağırsak mikrobiyotası arasındaki etkileşimi ve sistemik hastalıklar ile mikrobiyota arasındaki çift yönlü ilişkiyi ele almaktadır.

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Dental Diseases and Intestinal Dysbiosis Among Children

Abstract: It may be concluded that dysbiosis of GI microflora influences on a degree of dental hard tissue demineralization, which in turn may predispose to the formation of dental caries.

Cited by 6 publications

References 0 publications

Characterization of the oral microbiome and gut microbiome of dental caries and extrinsic black stain in preschool children

Characterization of the oral microbiome and gut microbiome of dental caries and extrinsic black stain in preschool children

Oralbiotica/Oralbiotics: The Impact of Oral Microbiota on Dental Health and Demineralization: A Systematic Review of the Literature

Evaluation of the Effects of Gut Flora on General Health and Oral Health

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